Activation of Cathepsins B and L in Mouse Lymphosarcoma Tissue under the Effect of Cyclophosphamide Is Associated with Apoptosis Induction and Infiltration by Mononuclear Phagocytes
Abstract:We analyzed activities of lysosomal cystein cathepsins B and L in mouse LS lymphosarcoma and its drug-resistant RLS 40 strain and their correlations with the dynamics of the percentage of cells with fragmented DNA and CD14 (+) phagocytes over 3 days after cyclophosphamide injection. LS regression and inhibition of RLS 40 growth after cyclophosphamide injection were paralleled by an increase in cathepsins B and L activities in tumor tissues. The antitumor effect of cyclophosphamide associated with apoptosis int… Show more
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