Behavioral effects and inflammatory markers in the brain and periphery after repeated social defeat stress burdened by Opisthorchis felineus infection in mice

Августинович, Д. Ф.; Tenditnik, Mikhail V.; Bondar, Natalia P.; Marenina, Mariya K.; Zhanaeva, S. Ya.; Lvova, Maria; Katokhin, Alexey V.; Pavlov, Konstantin S.; Evseenko, V. I.; Толстикова, Т. Г.

doi:10.1016/j.physbeh.2022.113846

Cited by 2 publications

(1 citation statement)

References 82 publications

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“…In addition, genes related to the HPA axis may influence the risk of depressive and posttraumatic stress symptoms contingent on the experience of child abuse ( Gillespie et al, 2009 ). The social defeat stress, an important animal model, which mice and rats are exposed to repeated social stress causes biological alterations, such as changes in corticosterone levels and it is can be related with genetic alterations ( Ajayi et al, 2022 ; Avgustinovich et al, 2022 ).…”

Section: Depression and Resilience To Stress: Genetic Factorsmentioning

confidence: 99%

Neurobiological mechanisms of mood disorders: Stress vulnerability and resilience

Marcolongo-Pereira

Castro

Barcelos

et al. 2022

Front. Behav. Neurosci.

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Stress is an important factor in the development of several human pathologies. The response of rodents and humans to stress depends on many factors; some people and rodents develop stress-related mood disorders, such as depression and anxiety in humans, depression-like and anxiety-like behavior in mice and rats, while others report no new psychological symptoms in response to chronic or acute stress, and are considered susceptible and resilient to stress, respectively. Resilience is defined as the ability to thrive in the face of adversity and is a learned process that can help protect against occupational stressors and mental illnesses. There is growing interest in the underlying mechanisms involved in resilience and vulnerability to depression caused by stress, and some studies have demonstrated that individual variability in the way animals and humans respond to stress depends on several mechanisms, such as oxidative stress, neuronal plasticity, immunology and genetic factors, among others not discussed in this review, this review provides a general overview about this mechanism.

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Section: Depression and Resilience To Stress: Genetic Factorsmentioning

confidence: 99%

Neurobiological mechanisms of mood disorders: Stress vulnerability and resilience

Marcolongo-Pereira

Castro

Barcelos

et al. 2022

Front. Behav. Neurosci.

View full text Add to dashboard Cite

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Mechanisms of adaptation of the hypothalamic-pituitary-adrenal axis in male mice under chronic social defeat stress

Sapronova,

Ryabushkina,

Kisaretovа

et al. 2024

Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova

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The hypothalamic-pituitary-adrenal axis (HPA) plays an important role in the mechanisms of adaptation to chronic stress. A model of chronic social defeat stress (CSDS), based on the experience of defeat in daily agonistic interactions, causes the development of a depressive-like state in mice, which is often accompanied by an increase in blood corticosterone levels. In this work, we assessed what changes occur in the central (hypothalamus) and peripheral (adrenal glands) parts of the HPA axis under the influence of chronic social stress, which can affect the regulation of corticosterone synthesis and its level in the blood. The experience of chronic social stress causes an increase in the relative weight of the adrenal glands, an increase in the expression level of Crh gene in the hypothalamus and the expression of the genes for the corticosterone synthesis enzymes Star, Cyp11a1, Cyp11b1 in the adrenal glands. At the same time, in the hypothalamus the expression of Fkbp5 and Nr3c1 decreases and the expression of Crhbp increases, and in the adrenal glands the expression of the Mc2r and Hsd11b1 genes decreases, which is ultimately aimed at reducing the amount of corticosterone secreted by the adrenal glands, and thus limiting the glucocorticoid response. Thus, chronic stress leads to an imbalance of the activating and stabilizing mechanisms of HPA axis regulation and a possible inadequate response to additional stress stimuli.

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Behavioral effects and inflammatory markers in the brain and periphery after repeated social defeat stress burdened by Opisthorchis felineus infection in mice

Cited by 2 publications

References 82 publications

Neurobiological mechanisms of mood disorders: Stress vulnerability and resilience

Neurobiological mechanisms of mood disorders: Stress vulnerability and resilience

Mechanisms of adaptation of the hypothalamic-pituitary-adrenal axis in male mice under chronic social defeat stress

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