Activation of cardiac progenitor cells through paracrine effects of mesenchymal stem cells

Impact of anti-apoptotic and anti-oxidative effects of bone marrow mesenchymal stem cells with transient overexpression of heme oxygenase-1 on myocardial ischemia

“…The present data showed that transplantation of MSC HO-1 rather than MSCs resulted in a reduction of apoptosis of cardiomyocytes in vivo. Additionally, our previous data suggested that MSC HO-1 may support the growth of c-kit ϩ cardiac progenitor cells by enhancing their mobility (34). Thus both the cell protection and activation and the paracrine effects of MSC HO-1 may contribute to the reduction of tissue injury and preservation of LV function after acute myocardial ischemia.…”

“…As shown in the in vitro study using H 2 O 2 , overexpressed HO-1 may have an anti-oxidative effect to support MSC survival even after transplantation. As for anti-apoptotic effects, we previously reported that MSC-derived cytokines accelerated the phosphorylation of Akt, which plays a pivotal role in cell apoptosis (34) and activates HO-1 expression and function in the presence of mediators (17). In addition, MSCs genetically modified with the Akt gene had improved cell viability, metabolic characteristics, and even proliferative capacity (29).…”

Paracrine factors from mesenchymal stem cells attenuate epithelial injury and lung fibrosis

“…These findings indicate that the beneficial effects of BM-MSCs on AECs can be exerted by their paracrine properties. Previous studies have shown that the paracrine factors of MSCs have anti-apoptotic effects in vitro on cardiac cells (27,28), pancreatic β cells (29) and hepatocytes (19). BM-MSCs are known to produce several epithelial specific growth factors, including HGF and KGF (17,18), which have been proven to initiate a variety of biological responses including migration, proliferation, and morpho genesis in AECs (30)(31)(32)(33).…”

Transplantation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells or Their Conditioned Medium Prevents Bone Loss in Ovariectomized Nude Mice

“…21 In addition, MSC-derived CM promotes proliferation of cardiac progenitor cells and inhibits apoptosis induced by hypoxia and serum starvation. 42 More recently, Jung et al showed that ex vivo culture of MSCs in the presence of human cord blood serum results in selective activation of platelet-derived THERAPY WITH HUMAN UCB-MSCS AND CONDITIONED MEDIUM IN OVX NUDE MICEgrowth factor and epidermal growth factor signals in MSCs, and that the cells exhibit higher self-renewal and enhanced osteogenic potential. 43 All of these studies demonstrated the beneficial effects of MSC CM or cord blood serum in terms of cell proliferation or local tissue repair.…”