Activation of AMP‐activated protein kinase on human gastric cancer cells by apoptosis induced by corosolic acid isolated from <i>Weigela subsessilis</i>

Lee, Myung Sun; Lee, Chang Min; Young, Eun; Thương, Phương Thiện; Bae, KiHwan; Song, In Sang; Noh, Seung Man; Sul, Ji Young

doi:10.1002/ptr.3210

Cited by 25 publications

(24 citation statements)

References 21 publications

(22 reference statements)

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“…Recently, different groups including us [38] have demonstrated that AMPK is an important regulator for cell apoptosis [39], [40], [41], [42], [43], [44].This serine/threonine kinase is originally thought to act as a cellular energy sensor by stimulating ATP-producing catabolic pathways and inhibiting ATP-consuming anabolic pathways [45], [46]. We and others proved that sustained AMPK activation could also promote cell apoptosis by regulating its downstream signals, including JNK [47], [48], [49], p38 [50], [51], p53 [52], [53].…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg-1 Protects Retinal Pigment Epithelium (RPE) Cells from Cobalt Chloride (CoCl2) and Hypoxia Assaults

Zhang

Yao

et al. 2013

PLoS ONE

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Severe retinal ischemia causes persistent visual impairments in eye diseases. Retinal pigment epithelium (RPE) cells are located near the choroidal capillaries, and are easily affected by ischemic or hypoxia. Ginsenoside Rg-1 has shown significant neuroprotective effects. This study was performed to test the cytoprotective effect of ginsenoside Rg-1 in RPE cells against hypoxia and cobalt chloride (CoCl2) assaults, and to understand the underlying mechanisms. We found that Rg-1 pre-administration significantly inhibited CoCl2- and hypoxia-induced RPE cell death and apoptosis. Reactive oxygen specisis (ROS)-dependent p38 and c-Jun NH(2)-terminal kinases (JNK) MAPK activation was required for CoCl2-induced RPE cell death, and Rg-1 pre-treatment significantly inhibited ROS production and following p38/JNK activation. Further, CoCl2 suppressed pro-survival mTOR complex 1 (mTORC1) activation in RPE cells through activating of AMP-activated protein kinase (AMPK), while Rg-1 restored mTORC1 activity through inhibiting AMPK activation. CoCl2-induced AMPK activation was also dependent on ROS production, and anti-oxidant N-acetylcysteine (NAC) prevented AMPK activation and RPE cell death by CoCl2. Our results indicated that Rg-1 could be further investigated as a novel cell-protective agent for retinal ischemia.

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Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg-1 Protects Retinal Pigment Epithelium (RPE) Cells from Cobalt Chloride (CoCl2) and Hypoxia Assaults

Zhang

Yao

et al. 2013

PLoS ONE

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“…Interestingly, the MeOH extract of the aerial parts of W. subsessilis contains triterpenoids such as corosolic acid, which has been shown to exhibit strong ARI effects. Corosolic acid has a structure that is closely related to those of other known ARIs, such as ganoderic acid C2 and ganoderenic A [19,20,21]. These related studies support that W. subsessilis contains ARIs.…”

Section: Resultssupporting

confidence: 54%

Inhibitory effects ofSynurus excelsusandWeigela subsessilison aldose reductase and HPLC-UV analysis of scopolin, scopoletin, and quercetin

Quilantang

Lee

Ryu

et al. 2018

JABC

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The inhibition of aldose reductase (AR) has been shown to prevent the progression of the many complications associated with diabetic hyperglycemia. Several compounds purified from various plant sources have exhibited potent inhibition against AR. In this study, the inhibitory effects of the methanol extracts of the flowers of Synurus excelsus and Weigela subsessilis on AR were determined in vitro. Scopolin and scopoletin are coumarins isolated from the flowers of S. excelsus and W. subsessilis; and quercetin is a known AR inhibitor present in many flowers. To determine and quantify their presence in both plants, HPLC-UV analysis of all three compounds was performed. S. excelsus and W. subsessilis showed potent inhibition against AR having IC 50 values of 0.17 and 0.14 μg/mL , respectively. The concentration of scopolin in S. excelsus and W. subsessilis were 34.71 and 174.14 mg/g extract, respectively. Scopoletin was detected in S. excelsus at 3.41 mg/g extract, whereas quercetin was not detected in both plants. This study shows that S. excelsus and W. subsessilis exhibited promising AR inhibitory effects and are both sources of coumarins.

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“…Lee et al () have conducted several studies on the ability of corosolic acid to induce cell cycle arrest and programmed cell death in human gastric cancer cells. In one gastric cancer cell line, corosolic acid was shown to act by activation of AMP‐activated protein kinase and caspase‐3, leading to programmed cell death.…”

Section: In Vitro Studiesmentioning

confidence: 99%

A Review of the Efficacy and Safety of Banaba (Lagerstroemia speciosa L.) and Corosolic Acid

Stohs

Miller²,

Kaats

2011

Phytotherapy Research

106

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Banaba (Lagerstroemia speciosa L.) extracts have been used for many years in folk medicine to treat diabetes, with the first published research study being reported in 1940. This review summarizes the current literature regarding banaba and its constituents. The hypoglycemic effects of banaba have been attributed to both corosolic acid as well as ellagitannins. Studies have been conducted in various animal models, human subjects and in vitro systems using water soluble banaba leaf extracts, corosolic acid-standardized extracts, and purified corosolic acid and ellagitannins. Pure corosolic acid has been reported to decrease blood sugar levels within 60 min in human subjects. Corosolic acid also exhibits antihyperlipidemic, antioxidant, antiinflammatory, antifungal, antiviral, antineoplastic and osteoblastic activities. The beneficial effects of banaba and corosolic acid with respect to various aspects of glucose and lipid metabolism appear to involve multiple mechanisms, including enhanced cellular uptake of glucose, impaired hydrolysis of sucrose and starches, decreased gluconeogenesis and the regulation of lipid metabolism. These effects may be mediated by PPAR, MAP K, NF-κB and other signal transduction factors. No adverse effects have been observed or reported in animal studies or controlled human clinical trials. Banaba extract, corosolic acid and other constituents may be beneficial in addressing the symptoms associated with metabolic syndrome, as well as offering other health benefits.

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Activation of AMP‐activated protein kinase on human gastric cancer cells by apoptosis induced by corosolic acid isolated from Weigela subsessilis

Cited by 25 publications

References 21 publications

Ginsenoside Rg-1 Protects Retinal Pigment Epithelium (RPE) Cells from Cobalt Chloride (CoCl2) and Hypoxia Assaults

Ginsenoside Rg-1 Protects Retinal Pigment Epithelium (RPE) Cells from Cobalt Chloride (CoCl2) and Hypoxia Assaults

Inhibitory effects ofSynurus excelsusandWeigela subsessilison aldose reductase and HPLC-UV analysis of scopolin, scopoletin, and quercetin

A Review of the Efficacy and Safety of Banaba (Lagerstroemia speciosa L.) and Corosolic Acid

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