Activation of a mouse macrophage cell line by acemannan: The major carbohydrate fraction from Aloe vera gel

Zhang, Linna; Tizard, Ian R.

doi:10.1016/s0162-3109(96)00135-x

Cited by 210 publications

(140 citation statements)

References 8 publications

Supporting

Mentioning

134

Contrasting

Unclassified

Order By: Relevance

“…The results showed that acemannan significantly stimulated the KGF-1 and VEGF synthesis from GFs. Previous studies have reported that acemannan stimulated macrophage and dendritic cell cytokine production (10,26). Our data demonstrated that acemannan also enhanced production of growth factors from GFs.…”

Section: Discussionsupporting

confidence: 77%

See 1 more Smart Citation

Acemannan Stimulates Gingival Fibroblast Proliferation; Expressions of Keratinocyte Growth Factor-1, Vascular Endothelial Growth Factor, and Type I Collagen; and Wound Healing

et al. 2009

View full text Add to dashboard Cite

Abstract. Aloe vera has long been used as a traditional medicine for inducing wound healing. Gingival fibroblasts (GFs) play an important role in oral wound healing. In this study, we investigated the effects of acemannan, a polysaccharide extracted from Aloe vera gel, on GF proliferation; keratinocyte growth factor-1 (KGF-1), vascular endothelial growth factor (VEGF), and type I collagen production; and oral wound healing in rats. [ 3 H]-Thymidine incorporation assay and ELISA were used. Punch biopsy wounds were created at the hard palate of male Sprague Dawley rats. All treatments (normal saline; 0.1% triamcinolone acetonide; plain 1% Carbopol ® ; and Carbopol ® containing 0.5%, 1%, and 2% acemannan (w /w)) were applied daily. Wounded areas and histological features were observed at day 7 after treatment. From our studies, acemannan at concentrations of 2, 4, 8, and 16 mg/ml significantly induced cell proliferation (P<0.05). Acemannan concentrations between 2 -16 mg/ml significantly stimulated KGF-1, VEGF, and type I collagen expressions (P<0.05). Wound healing of animals receiving Carbopol ® containing 0.5% acemannan (w /w) was significantly better than that of the other groups (P<0.05). These findings suggest that acemannan plays a significant role in the oral wound healing process via the induction of fibroblast proliferation and stimulation of KGF-1, VEGF, and type I collagen expressions.

show abstract

Section: Discussionsupporting

confidence: 77%

“…Acemannan, β-(1,4)-acetylated polymannose, is the major polysaccharide of Aloe vera gel (9). Reports have stated that it exerts an immunostimulative effect by activating macrophages (10,11). However, the roles of acemannan on GF proliferation and in vivo oral wound healing have never been reported.…”

Section: Introductionmentioning

confidence: 99%

Acemannan Stimulates Gingival Fibroblast Proliferation; Expressions of Keratinocyte Growth Factor-1, Vascular Endothelial Growth Factor, and Type I Collagen; and Wound Healing

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Aloe vera has a role in macrophage phagocytosis activity (Zhang & Tizard, 1996;Djeraba & Quere, 2000;Lee et al, 2001;Sun-Ai et al, 2005) and consequently in the resolution of the inflammation. Furthermore, mannose-6-phosphate has been shown to act as an anti-inflammatory agent and is present in the plant (Davies et al, 1994), which explains the lower inflammation in the Aloe vera group at the first day.…”

Section: Group 3: Control Groupmentioning

confidence: 99%

Effect ofAloe vera. on Rat Pulp Tissue

Gala-García

Teixeira

Mendes

et al. 2008

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…Nitric oxide production, cell morphologic changes and surface antigen expression were increased in response to stimulation by a mixture of acemannan and IFN-r. These results suggest that acemannan may function, at least in part, through macrophage activation [31] .…”

Section: Biological Propertiesmentioning

confidence: 80%