ACTIVATION ANTIGEN EXPRESSION ON PERIPHERAL BLOOD NEUTROPHILS FOLLOWING RAT SMALL BOWEL TRANSPLANTATION NKR-P1 is A NOVEL ANTIGEN PREFERENTIALLY EXPRESSED DURING ALLOGRAFT REJECTION

Webster, G. A.; Bowles, M. J.; Karim, Md. Sydul; Wood, R. F.; Pockley, A. Graham

doi:10.1097/00007890-199409000-00012

Cited by 19 publications

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“…Currently, endoscopically guided biopsies are the gold standard for diagnosing rejection. Other methods such as measuring specific cytokines or measuring changes in mucosal permeability have thus far been too impractical or nonspecific to detect early rejection (11‐15). Endoscopy itself, without biopsy, is also too insensitive to diagnose early rejection (9,10), and harvesting tissue for histology remains necessary for establishing a definitive diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Anatomic Variability of Rejection in Intestinal Allografts After Pediatric Intestinal Transplantation

Sigurdsson,

Reyes,

Todo

et al. 1998

J. pediatr. gastroenterol. nutr.

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Background:Rejection of the allograft is a major contributor to morbidity and mortality in children who undergo a small intestinal transplant. Operational definitions for histologic rejection have been established, but little is known about the anatomic variability of the histologic abnormalities.Study Design:Biopsy reports were reviewed retrospectively from more than 1200 endoscopies performed on the 41 children who received intestinal transplantation between 1990 and 1995.Results:Biopsies were performed in the proximal jejunum and distal ileum allograft simultaneously on 248 occasions. In 168 biopsies, neither site was histologically abnormal; in 80, rejection was found. In 42, both regions were abnormal; however, in 17 only the jejunum was involved and in 21 the rejection exclusively involved the ileum. Among children whose allograft included colon, rejection was absent in colon and ileum in 34 biopsies, involved both in 6, involved ileum but not colon in another 6 and involved colon but not ileum in only one. When the allograft included stomach, rejection was absent in the stomach and jejunum 39 times, involved both sites 8 times, involved jejunum and not the stomach 10 times, but involved the stomach and not jejunum only once. Endoscopic appearance correctly predicted histologic rejection 63% of the time.Conclusion:Anatomic variability may exist in the rejection process. Sampling the jejunum and ileum seems to have similar sensitivity in detecting rejection, whereas sampling stomach and the colon is less sensitive. When allograft rejection is suspected on clinical grounds, sampling more than one area of the graft may be necessary for histologic confirmation.

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Section: Discussionmentioning

confidence: 99%

Anatomic Variability of Rejection in Intestinal Allografts After Pediatric Intestinal Transplantation

Sigurdsson,

Reyes,

Todo

et al. 1998

J. pediatr. gastroenterol. nutr.

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KLRB Receptor Family and Human Early Activation Antigen (CD69)

Gupta

2012

Animal Lectins: Form, Function and Clinical Applications

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Increased urinary nitrate excretion associated with hepatic allograft rejection in experimental rat models and clinical cases

Uchiyama

Yanaga

Kishihara

et al. 2000

Transplant International

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In this study, we investigated the relationship between excretion of urinary nitrate as a stable end-product of nitric oxide (NO) metabolism and hepatic allograft rejection. In experimental rat models, hepatic allograft rejection was associated with increased nitrate excretion with a peak on postoperative day 5. The severity of the hepatic allograft rejection was dependent on the increased urinary nitrate excretion. No significant increase in urinary nitrate excretion was observed in cases in which effective immunosuppression was achieved. Inducible nitric oxide synthase mRNA expression was upregulated parallel to interferon-gamma gene expression in the graft-infiltrating mononuclear cells and spleen cells from the recipients. In clinical cases, urinary nitrate excretion increased parallel to increased serum cytosolic enzymes that accompanied rejection. These results suggest that urinary nitrate excretion is a useful indicator for the surveillance of graft rejection and the monitoring of therapeutic effects of antirejection treatments.

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ACTIVATION ANTIGEN EXPRESSION ON PERIPHERAL BLOOD NEUTROPHILS FOLLOWING RAT SMALL BOWEL TRANSPLANTATION NKR-P1 is A NOVEL ANTIGEN PREFERENTIALLY EXPRESSED DURING ALLOGRAFT REJECTION

Cited by 19 publications

References 0 publications

Anatomic Variability of Rejection in Intestinal Allografts After Pediatric Intestinal Transplantation

Anatomic Variability of Rejection in Intestinal Allografts After Pediatric Intestinal Transplantation

KLRB Receptor Family and Human Early Activation Antigen (CD69)

Increased urinary nitrate excretion associated with hepatic allograft rejection in experimental rat models and clinical cases

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