Activation and inducer subset phenotype of the lymphocytic infiltrate around epidermally derived tumors

Markey, Andrew C.; Churchill, Linda J.; Allen, Michael; Macdonald, D.M.

doi:10.1016/0190-9622(90)70201-r

Cited by 16 publications

(4 citation statements)

References 15 publications

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“…It has been shown in a range of cutaneous tumours that the NK cell compartment of mononuclear cells is unlikely to be of central importance in host antitumour responses [17], suggesting a major role for T lymphocyte-mediated antitumour mechanisms [18][19][20]. We confirmed these findings by phenotypie analysis of uncultured TILs obtained from early primary melanoma.…”

Section: Discussionsupporting

confidence: 80%

Tumour-infiltrating lymphocytes in primary melanoma: functional consequences of differential IL-2 receptor expression

Becker

Schwinn

Dummer

et al. 1993

Clinical and Experimental Immunology

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SUMMARYTumour-infillraling lymphocytes (TIL) have been isolated from early priniarv melanoma (Clark level 111) and expanded in vitro using culliirc conditions wiih low concentraiions of lL-2 (50 U/ml). Immediately after isolation TIL consisted of mainly CD3' T cells, and the portion of CD56 + natural killer (NK) cells was below 20%. Fresh TIL cultures could be distinguished by CD25 expression since some contained up lo 33' Vn. others less than 5"A. CD25 ' cells. These showed differences in subsequent development during/rt )•///•() expansion. CD25-cxpre,ssingcultures remained stable in their phenotype. whereas the second TIL type showed major changes: CD3 (ca 1Q-7>{}"A.) expression decrease. CD25 (ca 5-35'^) and CD56 (ea 15-S5'Vu) expression increase. The TIL type, which remained dominated by CD3^ T eells, killed autologous tumour cells efficiently (^'Cr-rclease greater than 3O''a at a E/T ratio of 20:1). which could be blocked by MoAbs against MHC class 1 molecules. In contrast, the other TIL typcexhibited weak cytotoxicity(less than 17"-., ''Cr-releaseal an E/T ratio of 20:1) against the autologous tumour. Therefore, the expression of CD25 on freshly isolated TIL is a good marker for tumour specificity of in vitro expanded TIL.

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Section: Discussionsupporting

confidence: 80%

Tumour-infiltrating lymphocytes in primary melanoma: functional consequences of differential IL-2 receptor expression

Becker

Schwinn

Dummer

et al. 1993

Clinical and Experimental Immunology

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“…1,2 These T cells are only sporadically seen within the tumour nests, indicating the lack of an effective cell-mediated immune response. Major histocompatibility complex (MHC) class I and II antigens, intercellular adhesion molecule-1 (ICAM-1), CD40, and CD80 (B7.1) have been shown to play an important role in T-cell activation and proliferation.…”

Section: Introductionmentioning

confidence: 99%

Interferon-?-induced ICAM-1 and CD40 expression, complete lack of HLA-DR and CD80 (B7.1), and inconsistent HLA-ABC expression in basal cell carcinoma: a possible role for interleukin-10?

et al. 1999

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“…The variable peritumoural inflammatory infiltrate in BCC mainly consists of T lymphocytes, [1][2][3] but T-cell invasion of tumour nests, or T cells in close apposition with the tumour cells, are rarely observed. Together with molecules such as major histocompatibility complex (MHC) class I and II antigens and B7, ICAM-1 is an essential molecule in facilitating cytotoxicity towards tumour cells.…”

Section: Introductionmentioning

confidence: 99%

Expression of interferon-gamma receptors and interferon-gamma-induced up-regulation of intercellular adhesion molecule-1 in basal cell carcinoma; decreased expression of IFN-γR and shedding of ICAM-1 as a means to escape immune surveillance

et al. 1998

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Activation and inducer subset phenotype of the lymphocytic infiltrate around epidermally derived tumors

Cited by 16 publications

References 15 publications

Tumour-infiltrating lymphocytes in primary melanoma: functional consequences of differential IL-2 receptor expression

Tumour-infiltrating lymphocytes in primary melanoma: functional consequences of differential IL-2 receptor expression

Interferon-?-induced ICAM-1 and CD40 expression, complete lack of HLA-DR and CD80 (B7.1), and inconsistent HLA-ABC expression in basal cell carcinoma: a possible role for interleukin-10?

Expression of interferon-gamma receptors and interferon-gamma-induced up-regulation of intercellular adhesion molecule-1 in basal cell carcinoma; decreased expression of IFN-γR and shedding of ICAM-1 as a means to escape immune surveillance

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