Activated status of basophils in chronic urticaria leads to interleukin-3 hyper-responsiveness and enhancement of histamine release induced by anti-IgE stimulus

Abstract

Basophils of patients with CIU showed an activated profile, possibly due to an in vivo priming. Functionally, basophils have high responsiveness to IL-3 stimulation, thereby suggesting that defects in the signal transduction pathway after IgE cross-linking stimuli are recoverable in subjects with chronic urticaria.

Enhanced Basophil Reactivities during Severe Malaria and Their Relationship with the Plasmodium falciparum Histamine-Releasing Factor Translationally Controlled Tumor Protein

“…Ex vivo, activated basophils release histamine and cytokines in amounts that positively correlate with the level of CD203c expression (22). In addition to various immunomodulatory functions, histamine enhances endothelial permeability and has been associated with many pathophysiological features of cerebral malaria in a mouse model (1).…”

“…In these studies, it is widely accepted that expression of the basophil activation marker CD203c is well correlated with histamine release, which is no longer analyzed due to its great instability during storage. This strategy has begun to be more widely used in studies of other pathologies, such as helminth infections (11) or chronic idiopathic urticaria (22), although their . **, significant differences in median MFI between seropositive and seronegative groups (P Ͻ 0.05; Mann-Whitney test); *, differences with borderline significance (0.055 Ͻ P Ͻ 0.078; Mann-Whitney test).…”

Statin effects on regulatory and proinflammatory factors in chronic idiopathic urticaria

“…These patients had wheals daily or at least four times a week, for 6 weeks or longer. Patients with physical urticaria, urticarial vasculitis, food allergies or autoinflammatory diseases were excluded, as described previously [6,9]. None of the patients took corticosteroids or immunosuppressive drugs.…”

“…The pathogenic mechanism of CIU remains unknown, although some studies have demonstrated that patients may have intrinsic abnormalities in basophils or mast cells [6,7]. The inflammatory processes in CIU seem not to be limited to the consequences of mast/basophil degranulation [8].…”

Chronic Urticarial in Childhood. Immune Pathology of Chronic Urticarial in Children (Part I)

“…При хрониче-ской крапивнице установлено снижение высво-бождения гистамина при иммун ной стимуляции базофилов анти-IgE антителами и монокло-нальными анти-FСεRlα антителами при сохра-нении нормальной гистаминолиберации в от-вет на неиммунные стимулы (fMLP), действие которых опосредуется не высокоаффинными IgE-рецепторами [60]. Максимальное снижение высво бождения гистамина из базофилов в от-вет на анти-IgE антитела наблюдалось у больных с ау тоиммунной хронической крапивницей, ме-ханизм данного процесса остается неясным [62].…”