Activated factor XII levels and factor XII 46C&gt;T genotype in relation to coronary artery calcification in patients with type 1 diabetes and healthy subjects

Colhoun, Helen M.; Zito, Francesco; Chan, Norman; Rubens, Michael B.; Fuller, John; Humphries, Steve E.

doi:10.1016/s0021-9150(02)00022-9

Cited by 42 publications

(42 citation statements)

References 22 publications

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“…This finding is similar to others [18][19][20][21] . Orth et al [18] , in Germany, found no evidence that the 46C ] T polymorphism is associated with CAD or thrombophilia.…”

Section: Discussionsupporting

confidence: 93%

“…Orth et al [18] , in Germany, found no evidence that the 46C ] T polymorphism is associated with CAD or thrombophilia. Likewise, Colhoun et al [19] failed to establish an association between this polymorphism and coronary artery calcification in diabetic subjects and controls. Kohler et al [20] did not find an association either between the 46C ] T polymorphism and CAD.…”

Section: Discussionmentioning

confidence: 98%

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Factor XII 46C → T Gene Polymorphism in Chilean Subjects with Coronary Artery Disease and Controls

Caamaño

Jaramillo²,

Lanas³

et al. 2009

Med Princ Pract

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Objective: To investigate the possible association between factor XII (F12) gene variant and the presence of coronary artery disease (CAD) in Chilean subjects. Methods: A total of 112 unrelated patients with a diagnosis of CAD confirmed by angiography (33–74 years old) and 107 healthy controls (30–68 years old) were included in this study. PCR-RFLP was used to evaluate the 46C → T polymorphism of the F12 gene. Results: The genotype distribution for the 46C → T variant of the F12 gene in CAD patients (CC: 41%, CT: 39%, TT: 20%) and controls (CC: 38%, CT: 48%, TT: 14%) was comparable (p = 0.365). Similarly, the allelic frequency was equivalent (p = 0.833). The odds ratio for CAD associated with the mutated 46T allele was 1.06 (95% CI = 0.72–1.56) confirming the absence of an association. Conclusion: This study showed that the F12 46C → T gene polymorphism is not related to CAD in the studied population. However, this study is limited by its sample size and the use of controls not matched by age and sex.

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“…This finding is similar to others [18][19][20][21] . Orth et al [18] , in Germany, found no evidence that the 46C ] T polymorphism is associated with CAD or thrombophilia.…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 98%

Factor XII 46C → T Gene Polymorphism in Chilean Subjects with Coronary Artery Disease and Controls

Caamaño

Jaramillo²,

Lanas³

et al. 2009

Med Princ Pract

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“…108,109 High FXIIa levels were also associated with a higher and earlier recurrence rate of ACS in patients who survived a first MI 110 and were positively associated with coronary calcifications. 111 In the Study of Myocardial Infarction Leiden (SMILE), levels of FXII:C were decreased in men that had developed an MI, 112 whereas Merlo et al 106 did not find an effect on the levels of FXII:C in CAD. Furthermore, there are no convincing arguments for an effect in arterial thrombosis of FXII deficiency.…”

Section: Factor XIImentioning

confidence: 99%

Novel Insights into Genetics of Arterial Thrombosis

Konings¹,

Govers‐Riemslag²,

Cate

2010

Clinical Cardiogenetics

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“…Elevated plasma FXIIa levels have been documented in adult patients with severe sepsis and septic shock [10], acute renal failure [11], end-stage chronic renal failure [12], patients on hemodialysis [13,14], coronary artery calcification, and endothelial dysfunction [15]. Elevated FXIIa levels have also been documented in pediatric patients with hemolytic uremic syndrome who required dialysis [16].…”

Section: Introductionmentioning

confidence: 99%

Possible role of new pressor protein in hypertensive anephric hemodialysis patients

Pearl

Papageorgiou

Goldman

et al. 2003

Pediatric Nephrology

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Unexplained hypertension was observed in three anephric children on hemodialysis. We investigated the possible involvement of a novel hypertensive extra-renal enzyme new pressor protein (NPP), related to coagulation beta-FXIIa. Currently, NPP activity can only be determined by a rat bioassay model. On study day 1, pre dialysis, patients 1, 2, and 3 were hypertensive and their plasmas raised rat systolic blood pressure (SBP) by 45, 34, and 9 mmHg, respectively. Post dialysis, patients 1 and 2 reached their estimated dry body weight and their systemic pressures dropped, while patient 3 remained hypertensive and hypervolemic. Their post-dialysis plasmas raised rat SBP by 22, 14, and 9 mmHg, respectively. On day 2, similar relationships between patient SBP, volume status, and plasma NPP-like activity in rats were observed. The characteristic rat BP responses, lack of inhibition by captopril (ruling out a renin-mediated effect), and inhibition by soybean trypsin inhibitor support co-identity with NPP. Plasma FXIIa (combined alpha-FXIIa and beta-FXIIa) was measured by immunoassay and found to be elevated in all patients. This investigation suggests that there is high endogenous NPP activity in the plasmas of these hypertensive hemodialysis patients, it changes with SBP and fluid volume, and is a possible contributor to their hypertension. Further studies are required to examine the wider applicability of these novel findings.

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Activated factor XII levels and factor XII 46C>T genotype in relation to coronary artery calcification in patients with type 1 diabetes and healthy subjects

Cited by 42 publications

References 22 publications

Factor XII 46C → T Gene Polymorphism in Chilean Subjects with Coronary Artery Disease and Controls

Factor XII 46C → T Gene Polymorphism in Chilean Subjects with Coronary Artery Disease and Controls

Novel Insights into Genetics of Arterial Thrombosis

Possible role of new pressor protein in hypertensive anephric hemodialysis patients

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