Activated CD4+ T cells and CD14hiCD16+ monocytes correlate with antibody response following influenza virus infection in humans

Wong, Sook‐San; Oshansky, Christine M.; Guo, Xi-zhi J.; Ralston, Jacqui; Wood, Timothy; Reynolds, Gary; Seeds, Ruth; Jelley, Lauren; Waite, Ben; Jeevan, Trushar; Zanin, Mark; Widdowson, Marc‐Alain; Huang, Q. Sue; Webby, Richard J.; Turner, Nikki; Baker, Michael G; Grant, Cameron; McArthur, Colin; Roberts, Sally; Trenholmes, Adrian; Wong, Conroy; Taylor, Susan; Thompson, Mark G.; Gross, Diane; Duque, Jazmin; Haven, Kathryn; Aley, Debbie; Muponisi, Pamela; Chand, Bhamita; Chen, Yan; Plewes, L. W.; Sawtell, Frann; Lawrence, Shirley; Cogcoy, Reniza; Smith, J. R.; Gravidez, Franie; Ma, Mandy; Chamberlin, Shona; Davey, Kirstin; Knowles, Tania; McLeish, Jo-Ann; Todd, Angela; Bocacao, Judy; Gunn, Wendy; Kawakami, Pamela; Walker, Susan; Madge, Robyn; Moore, Nicole; Rahnama, Fahimeh; Qiao, Helen; Tse, Fifi; Zibaei, Mahtab; Korrapadu, Tirzah; Optland, Louise; Cruz, Cecilia Dela

doi:10.1016/j.xcrm.2021.100237

Cited by 7 publications

(12 citation statements)

References 51 publications

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“…Prior to the emergence of coronavirus disease 2019 (COVID-19), relatively few community surveillance studies that combine serologic with a molecular diagnosis were conducted. A seroepidemiologic study conducted in Singapore during the 2009 A(H1N1) pandemic reported that 80% of laboratory-confirmed individuals eventually seroconverted [101], while we observed only 32% of seroconversion in a New Zealand cohort during an A(H3N2) and IBV-dominated season [75]. In the latter study, seroconversion was more frequently observed in hospitalized patients, consistent with data from human challenge and COVID-19 studies [102] that suggest that severity of infection may correlate with the induction of antibody responses [95].…”

Section: Antibody Non-responsiveness After Infectioncontrasting

confidence: 59%

“…Recent studies have also identified the circulating counterpart of the CD4 + T-follicular helper cells (cTfh) as a marker of antibody responsiveness after influenza virus vaccination [74]. Identifying early cellular correlates of antibody production after infection is more challenging due to the difficulties in obtaining early blood samples, although we recently identified actively proliferating CD4 + T-cells as a cellular correlate of subsequent seroconversion [75]. Activated cTfh-1 has also been found to be a predictor of robust antibody response in SARS-CoV-2 infections [76,77].…”

Section: Cellular Correlates Of Antibody Responsementioning

confidence: 99%

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Antibody Responsiveness to Influenza: What Drives It?

Lin

Liang

et al. 2021

Viruses

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The induction of a specific antibody response has long been accepted as a serological hallmark of recent infection or antigen exposure. Much of our understanding of the influenza antibody response has been derived from studying antibodies that target the hemagglutinin (HA) protein. However, growing evidence points to limitations associated with this approach. In this review, we aim to highlight the issue of antibody non-responsiveness after influenza virus infection and vaccination. We will then provide an overview of the major factors known to influence antibody responsiveness to influenza after infection and vaccination. We discuss the biological factors such as age, sex, influence of prior immunity, genetics, and some chronic infections that may affect the induction of influenza antibody responses. We also discuss the technical factors, such as assay choices, strain variations, and viral properties that may influence the sensitivity of the assays used to measure influenza antibodies. Understanding these factors will hopefully provide a more comprehensive picture of what influenza immunogenicity and protection means, which will be important in our effort to improve influenza vaccines.

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Section: Antibody Non-responsiveness After Infectioncontrasting

confidence: 59%

Section: Cellular Correlates Of Antibody Responsementioning

confidence: 99%

Antibody Responsiveness to Influenza: What Drives It?

Lin

Liang

et al. 2021

Viruses

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“…Many studies have investigated age-dependent differences in immune response to respiratory viruses and collectively describe variations in inflammatory states and mucosal T cell responses at sites of infection ( Oshansky et al., 2014 ; Guo et al., 2018 ; Wong et al., 2021 ). These differences have been extensively reviewed ( Chen et al., 2020 ; Bajaj et al., 2021 ; Mettelman and Thomas, 2021 ).…”

Section: Biologic Factors Impacting Innate and Adaptive Immune Respon...mentioning

confidence: 99%

Mucosal immune responses to infection and vaccination in the respiratory tract

Mettelman

Allen²,

Thomas³

2022

Immunity

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100

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“…This sample size was based on our previous study evaluating differences in the immune profile associated with seroconversions. 20 HRs showed at least a four-fold increase in HI for both IAV vaccine strains post-vaccination, while LRs did not.…”

Section: Methodsmentioning

confidence: 84%

The impact of pre‐existing influenza antibodies and inflammatory status on the influenza vaccine responses in older adults

Kang

Lin

Jiang

et al. 2023

Influenza Resp Viruses

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Age‐associated immune changes and pre‐existing influenza immunity are hypothesized to reduce influenza vaccine effectiveness in older adults, although the contribution of each factor is unknown. Here, we constructed influenza‐specific IgG landscapes and determined baseline concentrations of cytokines typically associated with chronic inflammation in older adults (TNF‐α, IL‐10, IL‐6, and IFN‐γ) in 30 high and 29 low influenza vaccine responders (HR and LR, respectively). In a background of high H3 antibody titers, vaccine‐specific H3, but not H1, antibody titers were boosted in LRs to titers comparable to HRs. Pre‐vaccination concentrations of IL‐10 were higher in LRs compared with HRs and inversely correlated with titers of pre‐existing influenza antibodies. Baseline TNF‐α concentrations were positively correlated with fold‐increases in antibody titers in HRs. Our findings indicate that baseline inflammatory status is an important determinant for generating post‐vaccination hemagglutinin‐inhibition antibodies in older adults, and IgG responses can be boosted in the context of high pre‐existing immunity.

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Activated CD4+ T cells and CD14hiCD16+ monocytes correlate with antibody response following influenza virus infection in humans

Cited by 7 publications

References 51 publications

Antibody Responsiveness to Influenza: What Drives It?

Antibody Responsiveness to Influenza: What Drives It?

Mucosal immune responses to infection and vaccination in the respiratory tract

The impact of pre‐existing influenza antibodies and inflammatory status on the influenza vaccine responses in older adults

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