Activatable near-infrared emission-guided on-demand administration of photodynamic anticancer therapy with a theranostic nanoprobe

Abstract

A theranostic platform enables the selective visualization of H2S-rich cancers and imaging-directed on-demand photodynamic therapy of the detected cancers while leaving normal tissues untouched.

Fine-tuning the electronic structure of heavy-atom-free BODIPY photosensitizers for fluorescence imaging and mitochondria-targeted photodynamic therapy

“…To date, numerous organic dyes, such as porphyrins, phthalocyanines, cyanine, squaraine, diketopyrrolopyrrole (DPP), and boron dipyrromethane (BODIPY) derivatives, have been developed as theranostic agents. [7][8][9][10][11][12][13] Among these, BODIPY dyes have attracted great interest as theranostic agents in photodynamic cancer therapy due to their excellent photochemical stability, good biocompatibility, high molar extinction coefficients, high quantum efficiencies of uorescence and facile modication. [11][12][13][14][15][16][17] At present, for obtaining remarkable PDT efficiency of BODIPY dyes, the most popular approach is the introduction of heavy halogen atoms (Br and I) to promote spin-orbit coupling (SOC), which enhances intersystem crossing (ISC) and improves the singlet oxygen ( 1 O 2 ) generation capability.…”

“…[7][8][9][10][11][12][13] Among these, BODIPY dyes have attracted great interest as theranostic agents in photodynamic cancer therapy due to their excellent photochemical stability, good biocompatibility, high molar extinction coefficients, high quantum efficiencies of uorescence and facile modication. [11][12][13][14][15][16][17] At present, for obtaining remarkable PDT efficiency of BODIPY dyes, the most popular approach is the introduction of heavy halogen atoms (Br and I) to promote spin-orbit coupling (SOC), which enhances intersystem crossing (ISC) and improves the singlet oxygen ( 1 O 2 ) generation capability. [18][19][20][21][22][23][24] However, the incorporation of heavy atoms increases the dark-toxicity and quench uorescence.…”

Recent progress in H2S activated diagnosis and treatment agents

“…In addition, Wang et al 101 have designed and synthesized a theranostic prodrug (TNP-SO) for H 2 S-activatable nearinfrared emission-guided on-demand administration of PDT. The theranostic probe consists of an H 2 S-activated NIR imaging probe and a sensitizing drug.…”

Tailoring nanoparticles based on boron dipyrromethene for cancer imaging and therapy

“…After forming the stable nanoparticles in water, BDP NPs are widely used in the biomedical field because of their multifunction and good biocompatibility. Such applications include cellular imaging, fluorescence imaging, photoacoustic (PA) imaging, computed tomography (CT) imaging, photothermal therapy (PTT), and photodynamic therapy (PDT) as shown in Figure (Hendricks et al, ; Lin et al, ; Y. Liu, Song, Chen, Liu, & Xie, ; Miao et al, ; Reinhardt, Zhou, Jorgensen, Partipilo, & Chan, ; R. Wang, Dong, et al, ; Y. Zhang, Song, et al, ).…”