Fine-tuning the electronic structure of heavy-atom-free BODIPY photosensitizers for fluorescence imaging and mitochondria-targeted photodynamic therapy

Abstract

<p>We designed and investigated novel mitochondria-targeting heavy-atom-free BODIPY photosensitizers (R-<bold>BODs</bold>) that possessed considerable singlet oxygen generation abilities and good fluorescence properties for imaging-guided photodynamic therapy (PDT).</p>

Double-Stranded DNA Matrix for Photosensitization Switching

“…In recent studies, it was proposed that PSs with intramolecular charge-transfer (ICT) state may be benefit from the separated donor and acceptor structure in generating activated excited T 1 . [30][31][32] Therefore, the dihedral angle change of SG after binding with dsDNA may contribute to the ISC of SG. The binding conformation of SG with dsDNA was first simulated with molecular docking (Sybyl-X 2.0).…”

Design of BODIPY dyes as triplet photosensitizers: electronic properties tailored for solar energy conversion, photoredox catalysis and photodynamic therapy

“…The choice of examples was based not only on the intrinsic interest of the topic itself or its possible applications, but also on its educational value. It is worth mentioning that thiophene-fused BODIPYs, [10][11][12] BODIPY coupled to transition metal complexes 13 and, more recently, twisted BODIPYs 14,15 have been reported as efficient triplet sensitizers, but they will not be covered in this review and interested readers can refer to the above-mentioned literature. The fourth section of the review discusses the synthetic procedures used to synthesize the BODIPY dyes described in the previous section.…”

Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

“…Dipyrromethene boron difluoride (BODIPY)-derived fluorophores are widely used in the fields of NIR-I imaging and phototherapy due to the advantages of excellent chemical/photostability, high molar extinction coefficient, and low toxicity. 130 , 131 , 132 , 133 As a typical derivative of BODIPY, Aza-BODIPY has more prolonged absorption and emission wavelengths due to the replacement of the carbon atom at the meso-position by a nitrogen atom, resulting in pronounced red-shift. 134 Recently, some NIR-II fluorophores based on BODIPY/Aza-BODIPY have been developed ( Table 1 ).…”