Actions of tetraphenylboron on neuromuscular transmission in the biventer cervicis muscle of the chick

Marshall, Ian

doi:10.1016/0014-2999(70)90181-0

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Triethylcholine has a complex action in multiply innervated preparations, showing (1) a hemicholinium-like action reversible by choline (Marshall, 1969); (2) a tetraethylammonium-like action in increasing acetylcholine release in response to nerve stimulation (Roberts, 1962;Marshall, 1970); (3) a tubocurarine-like action (Roberts, 1962;Marshall, 1969); and (4) an anticholinesterase action (Marshall, 1969). My results, and those of Chiou & Long (1969), emphasize the need for careful interpretation of results obtained using such a drug with multiple actions at high concentrations.…”

Section: Discussionmentioning

confidence: 99%

Actions of acetylcholine and carbachol on the chick biventer cervicis muscle

Marshall

1971

British J Pharmacology

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Summary1. The possibility that carbachol may act on the chick biventer cervicis muscle by releasing acetylcholine was investigated. 2. Log dose-response curves for acetylcholine and carbachol were constructed in the presence of triethylcholine, tubocurarine and physostigmine, in both innervated and denervated chick biventer cervicis muscles. 3. The log dose-response curve for acetylcholine -was shallower than that for carbachol and was moved to the left by triethylcholine, indicating potentiation.In the presence of physostigmine, the curve was as steep as that for carbachol, and like that for carbachol was moved to the right by triethylcholine, indicating antagonism. In the presence of tubocurarine, the log dose-response curves for both acetylcholine and carbachol were moved to the right. 4. The log dose-response curves for both acetylcholine and carbachol were moved to the left by chronic denervation, indicating increased sensitivity to these drugs. Both curves were moved similar distances to the right by excess magnesium ion concentration. No tachyphylaxis developed to repeated administration of carbachol in the presence of triethylcholine or tubocurarine, either in innervated or denervated muscles. 5. It was concluded that the main action of triethylcholine in the chick biventer cervicis muscle is a tubocurarine-like action, which, in the presence of acetylcholine, is masked by a weak anticholinesterase action. It was also concluded that the diminished response to carbachol in the presence of triethylcholine is due to the postjunctional blocking action of triethylcholine. and that carbachol owes none of its activity to an ability to release acetylcholine from the nerve terminals.

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Section: Discussionmentioning

confidence: 99%

Actions of acetylcholine and carbachol on the chick biventer cervicis muscle

Marshall

1971

British J Pharmacology

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“…In addition Marshall (1970) postulated that the anti-curare activity of TPB was due to an augmentation of evoked transmitter release rather than to a depolarizing action. I Present address: Department of Physiology and Pharmacology, University of Stratliclydc, Glasgow GI 1 XW.…”

Section: Introductionmentioning

confidence: 99%

“…It has also been suggested that TPB acts as a cholinoceptor agonist at both parasympathetic neuroeffector junctions (Guideri, Seifter & Seifter, 1968) and the neuromuscular junction (Seifter, Guideri & Seifter, 1968), by interacting with the esteratic site of the acetylcholine receptor (Guideri, Seifter & Seifter, 1972). The claim that cholinoceptor activation could be produced by combination with the esteratic site alone was not substantiated by Marshall ( 1970) who found that TPB produced no contracture of the chick biventer cervicis muscle.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Tetraphenylboron on Neuromuscular Transmission in the Frog

Marshall

Parsons

1975

British J Pharmacology

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I The effects of tetraphenylboron (TPB) were studied on the frog sciatic nerve-sartorius muscle preparation. 2 TPB (0.01-1 mM) blocked indirectly elicited twitches of the preparation. 3 TPB (0.01-0.1 mM) produced no depolarization but lowered membrane resistance. TPB increased miniature endplate potential (m.e.p.p.) frequency, the rate of rise of the endplate potential (e.p.p.), and slowed the rate of rise and rate of fall of the muscle action potential.

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Effects of a negative quaternary ion-sodium tetraphenylboron (TPB) on the rat phrenic nerve-diaphragm preparation

Guideri

Seifter

1972

European Journal of Pharmacology

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Actions of tetraphenylboron on neuromuscular transmission in the biventer cervicis muscle of the chick

Cited by 4 publications

References 17 publications

Actions of acetylcholine and carbachol on the chick biventer cervicis muscle

Actions of acetylcholine and carbachol on the chick biventer cervicis muscle

The Effects of Tetraphenylboron on Neuromuscular Transmission in the Frog

Effects of a negative quaternary ion-sodium tetraphenylboron (TPB) on the rat phrenic nerve-diaphragm preparation

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