Actions of opioids on respiratory activity via activation of brainstem μ-, δ- and κ-receptors; an in vitro study

Takita, Kensuke; Herlenius, Eric; Lindahl, Sten G. E.; Yamamoto, Yuji

doi:10.1016/s0006-8993(97)01105-0

Cited by 63 publications

(40 citation statements)

References 30 publications

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“…Many studies have documented the broad activities of MOR, particularly in the control of nociception (2), respiration (70,71), cardiovascular functions (72), mood (73), and gastrointestinal secretion (3,5). Recently, immunomodulatory activities of endogenous and exogenous µ-, κ-, and δ-opioid compounds have been described, but their in vivo effects during colon inflammation remain unknown (74).…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory properties of the μ opioid receptor support its use in the treatment of colon inflammation

Philippe¹,

Dubuquoy²,

Groux³

et al. 2003

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory properties of the μ opioid receptor support its use in the treatment of colon inflammation

Philippe¹,

Dubuquoy²,

Groux³

et al. 2003

J. Clin. Invest.

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“…Clinically, the most effective opioid analgesics are -opioid receptor (MOR) agonists, but treatment with these drugs often results in undesirable side effects. In contrast, DOR agonists are promising candidates for drug development because they produce analgesia without the respiratory depression (Takita et al, 1997) and physical dependence (Devine and Wise, 1994) associated with -opioid analgesics.…”

Section: Indexing Terms: Opiates; Analgesia; Receptor Localization; Rmentioning

confidence: 99%

Comparison between δ‐opioid receptor functional response and autoradiographic labeling in rat brain and spinal cord

Pradhan

Clarke

2004

J of Comparative Neurology

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The distribution of delta-opioid receptors (DORs) in the rat central nervous system has been previously characterized by radioligand binding and immunohistochemistry. However, the functional neuroanatomy of DORs has not been mapped in any detail; this is potentially important, because these receptors appear to be primarily cytosolic. Opioid receptors can couple to G(i/o) G proteins, a process that is detected by agonist-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate ([35S]GTPgammaS) binding. The purpose of this study was therefore to determine the distribution of functional DORs, as assessed by [35S]GTPgammaS autoradiographic labeling in response to the DOR agonist deltorphin II. For comparison, adjacent sections were labeled with [125I]deltorphin II or the DOR antagonist [125I]AR-M100613. In all three assays, mu-opioid receptors were blocked pharmacologically. The distributions of [125I]deltorphin II and [125I]AR-M100613 were highly correlated but not identical. Deltorphin II increased [35S]GTPgammaS binding in a concentration-dependent and naltrindole-sensitive manner. The regional [35S]GTPgammaS response to deltorphin II was only moderately predicted by agonist or antagonist radioligand binding (r = 0.67 and 0.50, respectively). [35S]GTPgammaS responses to deltorphin II were strongest in the extended striatum (caudate putamen, nucleus accumbens, olfactory tubercle) and cerebral cortex. In contrast, some areas reported to mediate DOR analgesia (brainstem, spinal cord) possessed a much lower [35S]GTPgammaS response. These findings demonstrate the existence of a partial mismatch between DOR radioligand binding and [35S]GTPgammaS response. This divergence possibly reflects regional heterogeneity in G-protein receptor coupling, or in the subcellular localization of DOR.

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“…Blood b-endorphin levels were reportedly raised, with an increase in FEV 1 after 45-minutes of Acu-TENS in individuals with COPD [8]; b-endorphin acts on the m-receptors [17] located in the rhythm-generating component of the respiratory centre [18,19]. A slower respiratory rate is induced by stimulation of m-and d-opioid receptors [18,20]. Endorphin is also associated with a suppression of hyperventilation [18,21].…”

Section: Discussionmentioning

confidence: 99%

Effect of Acu-TENS on post exercise airway resistance in healthy individuals

Chan

Wong

et al. 2012

Hong Kong Physiotherapy Journal

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Transcutaneous electrical nerve stimulation on acupoints (Acu-TENS) is associated with increased exercise duration in healthy individuals and improves forced expiratory volume in 1 second (FEV 1 ) in those with respiratory illness. Whether a decrease in airway resistance (AR) is responsible for these respiratory system effects has not been investigated. This pilot study investigated the effect of a single session of Acu-TENS on AR in healthy people. Twenty individuals were invited to the laboratory twice, 1 week apart, to receive in random order either Acu-TENS or placebo-TENS (no electrical output from the TENS unit) over bilateral Lièqu e (LU 7) and Dìnchu an (EX-B1), for 45 minutes before and during a submaximal treadmill exercise test following the Bruce protocol. AR, FEV 1 , forced vital capacity, rate of perceived exertion and heart rate variability were recorded before, immediately after and 15 minutes after exercise. Immediately after exercise the percentage decrease in AR from baseline was greater in the Acu-TENS group (À20.10 AE 4.00%) compared to the placebo-TENS group (À7.99 AE 3.43%) (p Z 0.029). We conclude that the decrease in AR seen with Acu-TENS in healthy individuals could account for the immediate improvement in FEV 1 . Acu-TENS may have a role in decreasing AR in patients with airflow limitation.

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Actions of opioids on respiratory activity via activation of brainstem μ-, δ- and κ-receptors; an in vitro study

Cited by 63 publications

References 30 publications

Anti-inflammatory properties of the μ opioid receptor support its use in the treatment of colon inflammation

Anti-inflammatory properties of the μ opioid receptor support its use in the treatment of colon inflammation

Comparison between δ‐opioid receptor functional response and autoradiographic labeling in rat brain and spinal cord

Effect of Acu-TENS on post exercise airway resistance in healthy individuals

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