Actions of neuropeptide Y on synaptic transmission in the lateral habenula

Cheon, Myunghyun; Park, Ho-Yong; Chung, ChiHye

doi:10.1016/j.ibror.2019.07.467

Cited by 2 publications

(2 citation statements)

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“…Moreover, cart2b , 3a , 3b , and 4 were expressed in the preoptic region (Figures 4d, 5c, 6b, and 8a), similar to that reported for other teleosts (Akash et al., 2014; Le et al., 2016; Mukherjee et al., 2012; Porter et al., 2017), suggesting that cart , like npya , might be involved as preoptic neuroendocrine regulators. npya was expressed ventrally in the left and right habenula (Figure 1f), which is homologous to the mammalian lateral habenula (Amo et al., 2010) where NPY modulates excitatory transmissions (Cheon et al., 2019). Moreover, lateral habenular NPY might be indirectly linked to the hedonic regulation of appetite in primates (reviewed by Rezitis et al.…”

Section: Discussionmentioning

confidence: 93%

Mapping key neuropeptides involved in the melanocortin system in Atlantic salmon (Salmo salar) brain

Norland

Eilertsen

Rønnestad

et al. 2022

J of Comparative Neurology

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The melanocortin system is a key regulator of appetite and food intake in vertebrates. This system includes the neuropeptides neuropeptide y (NPY), agouti‐related peptide (AGRP), cocaine‐ and amphetamine‐regulated transcript (CART), and pro‐opiomelanocortin (POMC). An important center for appetite control in mammals is the hypothalamic arcuate nucleus, with neurons that coexpress either the orexigenic NPY/AGRP or the anorexigenic CART/POMC neuropeptides. In ray‐finned fishes, such a center is less characterized. The Atlantic salmon (Salmo salar) has multiple genes of these neuropeptides due to whole‐genome duplication events. To better understand the potential involvement of the melanocortin system in appetite and food intake control, we have mapped the mRNA expression of npy, agrp, cart, and pomc in the brain of Atlantic salmon parr using in situ hybridization. After identifying hypothalamic mRNA expression, we investigated the possible intracellular coexpression of npy/agrp and cart/pomc in the tuberal hypothalamus by fluorescent in situ hybridization. The results showed that the neuropeptides were widely distributed, especially in sensory and neuroendocrine brain regions. In the hypothalamic lateral tuberal nucleus, the putative homolog to the mammalian arcuate nucleus, npya, agrp1, cart2b, and pomca were predominantly localized in distinct neurons; however, some neurons coexpressed cart2b/pomca. This is the first demonstration of coexpression of cart2b/pomca in the tuberal hypothalamus of a teleost. Collectively, our data suggest that the lateral tuberal nucleus is the center for appetite control in salmon, similar to that of mammals. Extrahypothalamic brain regions might also be involved in regulating food intake, including the olfactory bulb, telencephalon, midbrain, and hindbrain.

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Section: Discussionmentioning

confidence: 93%

Mapping key neuropeptides involved in the melanocortin system in Atlantic salmon (Salmo salar) brain

Norland

Eilertsen

Rønnestad

et al. 2022

J of Comparative Neurology

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“…The protein encoded by Nptx2 is also directly implicated in BDNF-mediated modulation of glutamatergic synapses, where it facilitates targeting and stabilization of AMPA receptors on excitatory synapses (Chang et al, 2010;Martin and Finsterwald, 2011;Pelkey et al, 2015). Npy is another differentially expressed gene (log2FC ϭ 0.75, p ϭ 2.24 ϫ 10 Ϫ5 ) that influences cortical excitability by reducing excitatory transmission onto neurons in the lateral habenula (Cheon et al, 2019) and inhibiting glutamatergic synaptic transmission in the hippocampus (Xapelli et al, 2008). NPY expression can slow the spread of seizures and has neuroprotective effects against excitotoxicity via increased BDNF signaling (Richichi et al, 2004;Xapelli et al, 2008).…”

Section: Trkb Signaling In Cort Interneurons Regulates Gene Pathways mentioning

confidence: 99%

TrkB Signaling Influences Gene Expression in Cortistatin-Expressing Interneurons

Maynard

Kardian

Hill

et al. 2020

eNeuro

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Brain-derived neurotrophic factor (BDNF) signals through its cognate receptor tropomyosin receptor kinase B (TrkB) to promote the function of several classes of inhibitory interneurons. We previously reported that loss of BDNF-TrkB signaling in cortistatin (Cort)-expressing interneurons leads to behavioral hyperactivity and spontaneous seizures in mice. We performed bulk RNA sequencing (RNA-seq) from the cortex of mice with disruption of BDNF-TrkB signaling in cortistatin interneurons, and identified differential expression of genes important for excitatory neuron function. Using translating ribosome affinity purification and RNA-seq, we define a molecular profile for Cort-expressing inhibitory neurons and subsequently compare the translatome of normal and TrkB-depleted Cort neurons, revealing alterations in calcium signaling and axon development. Several of the genes enriched in Cort neurons and differentially expressed in TrkB-depleted neurons are also implicated in autism and epilepsy. Our findings highlight TrkB-dependent molecular pathways as critical for the maturation of inhibitory interneurons and support the hypothesis that loss of BDNF signaling in Cort interneurons leads to altered excitatory/inhibitory balance.

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Actions of neuropeptide Y on synaptic transmission in the lateral habenula

Cited by 2 publications

References 0 publications

Mapping key neuropeptides involved in the melanocortin system in Atlantic salmon (Salmo salar) brain

Mapping key neuropeptides involved in the melanocortin system in Atlantic salmon (Salmo salar) brain

TrkB Signaling Influences Gene Expression in Cortistatin-Expressing Interneurons

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