Actions of Neuropeptide Y on Synaptic Transmission in the Lateral Habenula

Cheon, Myunghyun; Park, Ho-Yong; Rhim, Hyewon; Chung, ChiHye

doi:10.1016/j.neuroscience.2019.04.053

Cited by 9 publications

(6 citation statements)

References 48 publications

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“…Neuropeptide Y (NPY) has recently been shown to modulate both excitatory and inhibitory synaptic transmission within the LHb (Cheon et al, 2019). Specifically, NPY receptor activation appears capable of bidirectionally modulating excitatory input in different groups of neurons, and has a net reduction of inhibitory input mediated by Y1 receptors (Cheon et al, 2019(Cheon et al, , 2020.…”

Section: Neuropeptide Ymentioning

confidence: 99%

Inhibition Within the Lateral Habenula—Implications for Affective Disorders

Webster

Lecca

Wozny

2021

Front. Behav. Neurosci.

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The lateral habenula (LHb) is a key brain region implicated in the pathology of major depressive disorder (MDD). Specifically, excitatory LHb neurons are known to be hyperactive in MDD, thus resulting in a greater excitatory output mainly to downstream inhibitory neurons in the rostromedial tegmental nucleus. This likely results in suppression of downstream dopaminergic ventral tegmental area neurons, therefore, resulting in an overall reduction in reward signalling. In line with this, increasing evidence implicates aberrant inhibitory signalling onto LHb neurons as a co-causative factor in MDD, likely as a result of disinhibition of excitatory neurons. Consistently, growing evidence now suggests that normalising inhibitory signalling within the LHb may be a potential therapeutic strategy for MDD. Despite these recent advances, however, the exact pharmacological and neural circuit mechanisms which control inhibitory signalling within the LHb are still incompletely understood. Thus, in this review article, we aim to provide an up-to-date summary of the current state of knowledge of the mechanisms by which inhibitory signalling is processed within the LHb, with a view of exploring how this may be targeted as a future therapy for MDD.

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Section: Neuropeptide Ymentioning

confidence: 99%

Inhibition Within the Lateral Habenula—Implications for Affective Disorders

Webster

Lecca

Wozny

2021

Front. Behav. Neurosci.

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“…A recent study reported that NPY administration into the LHb reduced the spontaneous firing rate of LHb neurons, leading to hypoactivation of the LHb. These results suggest that NPY signaling partially mediates the protective roles in mood-related disorders ( Cheon et al, 2019 ). Thus, the upregulation of habenular Npy1r in CRS rats might be involved in suppressing the hyperactivation of LHb neurons ( Fig.…”

Section: Discussionmentioning

confidence: 81%

Gene Expression Profiling of the Habenula in Rats Exposed to Chronic Restraint Stress

Yoo

Kim

Son

et al. 2022

Molecules and Cells

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Chronic stress contributes to the risk of developing depression; the habenula, a nucleus in epithalamus, is associated with many neuropsychiatric disorders. Using genome-wide gene expression analysis, we analyzed the transcriptome of the habenula in rats exposed to chronic restraint stress for 14 days. We identified 379 differentially expressed genes (DEGs) that were affected by chronic stress. These genes were enriched in neuroactive ligand-receptor interaction, the cAMP (cyclic adenosine monophosphate) signaling pathway, circadian entrainment, and synaptic signaling from the Kyoto Encyclopedia of Genes and Genomes pathway analysis and responded to corticosteroids, positive regulation of lipid transport, anterograde trans-synaptic signaling, and chemical synapse transmission from the Gene Ontology analysis. Based on protein–protein interaction network analysis of the DEGs, we identified neuroactive ligand-receptor interactions, circadian entrainment, and cholinergic synapse-related subclusters. Additionally, cell type and habenular regional expression of DEGs, evaluated using a recently published single-cell RNA sequencing study (GSE137478), strongly suggest that DEGs related to neuroactive ligand-receptor interaction and trans-synaptic signaling are highly enriched in medial habenular neurons. Taken together, our findings provide a valuable set of molecular targets that may play important roles in mediating the habenular response to stress and the onset of chronic stress-induced depressive behaviors.

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“…In mice, Y1 and Y2 receptors, which are post-synaptic and pre-synaptic, respectively ( Shende and Desai, 2020 ), are expressed in the LHb ( Kopp et al, 2002 ; Stanić et al, 2006 ). In rats, exposure to NPY decreases the spontaneous firing rate of the LHb, leading to hypoactivation of the LHb, which is modulated by reduction of GABAergic transmission via the Y1 pathway ( Cheon et al, 2019 , 2020 ). Although a possible involvement of the habenula NPY-Y1 signaling in sexual and social behavior is not well known, NPY has been implicated in stress-related responses such as anxiety and depression ( Shende and Desai, 2020 ), which are closely associated with LHb dysfunction ( Hikosaka, 2010 ; Browne et al, 2018 ).…”

Section: Regulators Of Reproductive and Social Behaviors On The Habenulamentioning

confidence: 99%

“…In male mice, the AVP-V1aR signaling in the LHb has recently been implicated in the regulation of male-typical social communication including ultrasonic vocalization, but not other social functions such as aggression ( Rigney et al, 2020 ). On the other hand, AVP fibers in the medial division of the LHb (LHbM) derived from the PVN evoke GABA-mediated inhibition in the LHbM, which promotes escape behavior during stress coping ( Zhang et al, 2016 ), similar to the role of NPY on GABAergic LHb neurons ( Cheon et al, 2019 , 2020 ) (see above).…”

Section: Regulators Of Reproductive and Social Behaviors On The Habenulamentioning

confidence: 99%

Role of Habenula in Social and Reproductive Behaviors in Fish: Comparison With Mammals

Ogawa

Parhar

2022

Front. Behav. Neurosci.

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Social behaviors such as mating, parenting, fighting, and avoiding are essential functions as a communication tool in social animals, and are critical for the survival of individuals and species. Social behaviors are controlled by a complex circuitry that comprises several key social brain regions, which is called the social behavior network (SBN). The SBN further integrates social information with external and internal factors to select appropriate behavioral responses to social circumstances, called social decision-making. The social decision-making network (SDMN) and SBN are structurally, neurochemically and functionally conserved in vertebrates. The social decision-making process is also closely influenced by emotional assessment. The habenula has recently been recognized as a crucial center for emotion-associated adaptation behaviors. Here we review the potential role of the habenula in social function with a special emphasis on fish studies. Further, based on evolutional, molecular, morphological, and behavioral perspectives, we discuss the crucial role of the habenula in the vertebrate SDMN.

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Actions of Neuropeptide Y on Synaptic Transmission in the Lateral Habenula

Cited by 9 publications

References 48 publications

Inhibition Within the Lateral Habenula—Implications for Affective Disorders

Inhibition Within the Lateral Habenula—Implications for Affective Disorders

Gene Expression Profiling of the Habenula in Rats Exposed to Chronic Restraint Stress

Role of Habenula in Social and Reproductive Behaviors in Fish: Comparison With Mammals

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