Actions of ginsenoside Rb1 on choline uptake in central cholinergic nerve endings

Benishin, Christina G.

doi:10.1016/0197-0186(92)90061-u

Cited by 95 publications

(46 citation statements)

References 22 publications

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“…Thus, the suppression of Rb1 on SP-enhanced inflammatory mediators may provide a new approach for treating neurogenic inflammation. SP stimulated TNF-a production in rat peritoneal mast cells is involved with MAPKs signaling pathways [33]. We found that SP or allergen induced ERK, JNK and p38 MAP kinase pathways in RBL-2H3 cells and SP enhanced allergeninduced ERK1/2 more prominently than other MAP kinases.…”

Section: Discussionmentioning

confidence: 66%

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Enhancement of the release of inflammatory mediators by substance P in rat basophilic leukemia RBL-2H3 cells

Liao

Hou

Wang³

et al. 2006

J Biomed Sci

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SummarySubstance P (SP), a neurotransmitter, may play an important role in neurogenic inflammation. Ginseng has been used extensively in traditional medicine; however, few studies were focused on their anti-allergic effect. Therefore, the effect and mechanism of ginsenoside Rb1 on the SP enhancement of allergic mediators were explored. In this study, SP and dinitrophenyl-bovine serum albumin (DNP-BSA) were used to activate rat basophilic leukemia (RBL)-2H3 cells. The cultured supernatants were assayed for histamine, leukotriene C 4 (LTC 4 ) and interleulin-4 (IL-4) production. The mitogen-activated protein kinases (MAPKs) signaling pathway was determined by Western blotting analysis. We found that IgE/DNP-BSA, SP, ginsenoside Rb1, or MAPK specific inhibitors had no effect on cell viability and cytotoxicity. SP (30 lM) alone, did not induce histamine and LTC 4 release, but it enhanced allergen-induced histamine and LTC 4 release. In addition, SP significantly induced and enhanced allergen-activated IL-4. Ginsenoside Rb1 dosedependently inhibited these effects. SP enhanced the allergen-activated ERK pathway in RBL-2H3 cells, and Rb1 effectively inhibited the ERK pathway activation. Although MAPK specific inhibitors suppressed LTC 4 and IL-4, only U0126 inhibited the SP enhanced histamine release. These results demonstrate that Rb1 dose-dependently inhibited SP enhanced allergen-induced mediator release and its mechanism was through the inhibition of the ERK pathway.

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Section: Discussionmentioning

confidence: 66%

“…Ginsenoside Rb1 potentiates the effects of nerve growth factor on nerve fiber outgrowth [32] and increases choline uptake by the brain [33]. Previously, pretreatment of Rb1 (91 lM) had been shown to decrease histamine and LT in allergenactivated lung mast cells [17].…”

Section: Discussionmentioning

confidence: 99%

Enhancement of the release of inflammatory mediators by substance P in rat basophilic leukemia RBL-2H3 cells

Liao

Hou

Wang³

et al. 2006

J Biomed Sci

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“…Both ginsenosides Rb 1 and Rg 1 , can modulate acetylcholine release and re-uptake and the number of choline uptake sites especially in the hippocampus 71) . They also increase choline acetyltransferase levels in rodent brains 72) . Such data indicate that these compounds may improve central cholinergic function in humans and may be used to treat memory deficits 59) .…”

Section: Effect On Neurotransmitter Changes By Ginsenosidesmentioning

confidence: 99%

Perspectives for Ginsenosides in Models of Parkinson's Disease

2007

Journal of Ginseng Research

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: Ginseng, the root of Panax species, is a well-known herbal medicine. It has been used as traditional medicine in Korea, China and Japan for thousands of years and now is a popular and worldwide natural medicine. The active principles of ginseng are ginsenosides which are also called ginseng saponins. Traditionally ginseng has been used primarily as a tonic to invigorate weak body functions and help the restoration of homeostasis. Current in vivo and in vitro studies demonstrate its beneficial effects in a wide range of pathological conditions such as cardiovascular diseases, cancer, immune deficiency and hepatotoxicity. Moreover, recent research indicates that some of ginseng's active ingredients exert beneficial actions on aging and neurodegenerative disorders such as Parkinson´s disease. Essentially, antioxidant, antiinflammatory, anti-apoptotic and immunostimulant activities are mostly underlying the postulated ginseng-mediated protective mechanisms. Next to animal studies, data from neural cell cultures contribute to the understanding of these mechanisms which involve decreasing nitric oxide, scavenging of free radicals and counteracting excitotoxicity. This paper focuses on own and other neuroprotective data on ginseng for dopaminergic neurons and intends to show aspects where neuroprotection e.g. by ginsenosides, additionally or preceding standard Parkinson therapy, could come about as a valuable contribution to slow neurodegenerative processes.

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“…고려인삼의 주요 약리작용으로는 중추신경계의 흥분 진정 작용 [2], 항암 작용 [13], 혈압조절 작용 [12], 항당뇨 작용 [8], 항 산화 작용 [10], 항균 작용 [7]등에 효과가 있는 것으로 보고되고 있다. 이는 고려인삼의 주요 성분인 40여 종 이상의 사포닌 (saponin)을 비롯하여 비사포닌(non-saponin) 계열인 polyacetylene, polysaccharides, alkaloids, phenolic compounds 등에 의한 약효로 알려져 있으며, 이들 유효성분들 중 가장 중요한 약리활성 성분인 사포닌은 triterpenoid계의 dammarane계를 기본 골격으로 하여, 다른 식물 사포닌과는 달리 과량 투여에 의한 독성이 없을 뿐 아니라 용혈작용이 거의 없는 중성 배당체로 보고되고 있다 [3].…”

unclassified

“…Paper disc dimeter (8 mm) was included. Average of triplicate determinations, 2) Ginseng fine root extract was not added.…”

mentioning

confidence: 99%

Screening of Antimicrobial Activity Compounds from Korea Ginseng Fine Root

Ah-Reum¹,

Lee

2011

Journal of Life Science

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The study was performed to evaluate the antibacterial and antiviral activities of ginseng fine root in order to search for antibacterial substances. Among 8 kinds of fermentation strains, Lactobacillus plantarum was selected based on viable cell count and antibacterial activities during incubation. Optimum conditions of ginseng fine root fermentation for L. plantarum were incubation at 35℃ for 48 hr in 5% ginseng fine root broth. That methanolic extract of fermented ginseng fine root broth was observed to be antibacterial and have antiviral activities. The results of paper disc method of non-fermented extract and fermented extract measured against E. coli was 11 mm and 20 mm, S. aureus was 15 mm and 22 mm, respectively. Shaking flask method was observed to inhibit the growth E. coli and S. aureus in fermented extract by 99.9%. However, antiviral activity of Feline calicivirus (FCV) was mostly activated. Fermented extract was used to investigate the compositional changes of ginsenosides on HPLC analysis. By fermentation, ginsenoside Rg1, Re and Rd were increased, with Rd showing a significant increase of 50 μg/g. These results suggest that ginseng fine root extract is a useful resource.

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Actions of ginsenoside Rb1 on choline uptake in central cholinergic nerve endings

Cited by 95 publications

References 22 publications

Enhancement of the release of inflammatory mediators by substance P in rat basophilic leukemia RBL-2H3 cells

Enhancement of the release of inflammatory mediators by substance P in rat basophilic leukemia RBL-2H3 cells

Perspectives for Ginsenosides in Models of Parkinson's Disease

Screening of Antimicrobial Activity Compounds from Korea Ginseng Fine Root

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