To address twenty-first century challenges, Niles, Amundson, and Neault (2011) developed the Hope-Centered Model of Career Development (HCMCD) from which they derived the Hope-Centered Career Inventory (including domains of hope, selfreflection, self-clarity, visioning, goal setting/planning, implementing, and adapting). The current study tests the psychometric properties, structural, convergent, and discriminant validity of the Italian version of the HCCI. Confirmatory factor analyses in a sample of 536 healthcare professionals supported the validity of the measure among healthcare professional, confirmed the model of hope-centered career competencies, and reinforced the importance of hope for an effective career self-management in the current work context.