Action of β-endorphin and nonsteroidal anti-inflammatory drugs, and the possible effects of nonsteroidal anti-inflammatory drugs on β-endorphin

Luan, Yuanhang; Wang, Di; Yu, Qi Jing; Chai, Xiangping

doi:10.1016/j.jclinane.2016.12.016

Cited by 18 publications

(13 citation statements)

References 77 publications

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“…β-EP binds to opioid receptors thereby activating the endogenous analgesia system, which is located in the CNS. Moreover, this activation inhibits pain conduction and agitation of nociceptors to exert an analgesic effect [36]. These phenomena may be a reaction of the body against depression symptoms to overcome the psychological and somatic pain caused by MDD [37].…”

Section: Discussionmentioning

confidence: 99%

IL-10 is associated with increased mu-opioid receptor levels in major depressive disorder

et al. 2019

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Objective:Activation of the immune-inflammatory response system (IRS) and the compensatory immune-regulatory system (CIRS) and aberrations in endogenous opioids play a role in the pathophysiology of major depressive disorder (MDD). There are no studies which examined the associations between both systems in MDD. The aim of the present study was to examine the relation between β-Endorphin (β-EP), Endomorphin-2, and their mu-opioid receptor (MOR) as well as interleukin (IL)-6 and IL-10, an anti-inflammatory cytokine, in MDD patients.Method:The study included 60 depressed drug-free male patients and 30 matched controls. Serum β-EP, Endomorphin-2, MOR, IL-6 and IL-10 levels were measured using ELISA techniques.Results:The results revealed a significant increase in serum β-EP, MOR, IL-6 and IL-10 in MDD patients versus healthy controls. MOR levels were strongly associated with IL-10 levels. There were no significant correlations between endogenous opioids and IL-6 and IL-10.Conclusion:The results show that MOR levels may function as a possible component of the CIRS whilst there is no evidence that β-EP and EM-2 may modify the IRS. The significant correlation between MOR levels and IL-10 may be explained through central activation of the HPA-axis and increased B-cell numbers expressing MOR as a response to cytokine over-secretion in MDD.

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Section: Discussionmentioning

confidence: 99%

IL-10 is associated with increased mu-opioid receptor levels in major depressive disorder

et al. 2019

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“…When receiving pain, the pain receptors (through the spinal cord dorsal horn) send signals to the hypothalamus causing the release of substance P, a neuropeptide. In the peripheral nervous system, this signal causes the appointment of T-lymphocytes to the area where pain was perceived, then T-lymphocytes release β-endorphin allowing it to bind to opioid receptors in this localized region, causing direct inhibition of substance P that in turn lowers the number of excitatory pain signals sent to the brain [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of low-power laser therapy in improvement of the peripheral neuropathy induced by xenobiotics in rats

Mannaa

Abdel-Wahhab

Daoud

et al. 2021

Biochemistry and Biophysics Reports

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Background Peripheral neuropathy (PN) is the damage and dysfunction of neurons of the peripheral nervous system. The present study was conducted to estimate the effectiveness of low-power laser therapy (LPLT) in the management of PN in a rats’ model. Methods PN was induced by giving dichloroacetate (DCA) (250 mg/kg/day) for up to 12 weeks. Four groups of rats were used: control group, PN group, PN group treated with gabapentin and PN group treated with LPLT. The study was conducted for 8 weeks. The management of PN was estimated by behavioral tests which included hot plate and Morris water maze tests. Blood biochemical analysis were carried out. Results Using of hot plate test indicated thermal hypoalgesia and using Morris water maze test showed cognitive decline in PN rats. Treatment with LPLT or gabapentin improved both the pain sensations and deteriorated memory that occurred in the PN rats. Biochemical analysis showed that LPLT significantly decreased the elevated beta-endorphin level in PN rats, while gabapentin could not reduce it. Treatment PN rats with LPLT or gabapentin shifted the high levels of TNF-α, IL-1β and IL-10 cytokines back to their normal values. Serum nitric oxide and MDA significantly increased in the PN group together with significant reduction in the rGSH level, these values were significantly improved by LPLT application while this was not the case with gabapentin treatment. Furthermore, treatment with gabapentin or LPLT significantly reduced serum ALAT and ASAT activities which are otherwise increased in the PN group. S100B, PGE2, total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, urea and creatinine showed insignificant changes among all groups. Conclusions Our results showed that treatment with LPLT is more efficient than gabapentin in ameliorating the peripheral neuropathy induced by xenobiotics.

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“…However, β-endorphin also exhibits activity in peripheral tissues, most notably peripheral analgesia, through a mechanism involving an interplay with the immune system. In various inflammatory conditions, beta-endorphin released by T-cells activates ORs located on nerve endings thereby inhibiting the release of substance P and the reception of pain through sensory neurons [ 299 , 300 ].…”

Section: Neuropeptides and Melanomamentioning

confidence: 99%

Neuroendocrine Factors in Melanoma Pathogenesis

Scheau

Drăghici

Ilie

et al. 2021

Cancers

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Melanoma is one of the most aggressive skin cancers with a sharp rise in incidence in the last decades, especially in young people. Recognized as a significant public health issue, melanoma is studied with increasing interest as new discoveries in molecular signaling and receptor modulation unlock innovative treatment options. Stress exposure is recognized as an important component in the immune-inflammatory interplay that can alter the progression of melanoma by regulating the release of neuroendocrine factors. Various neurotransmitters, such as catecholamines, glutamate, serotonin, or cannabinoids have also been assessed in experimental studies for their involvement in the biology of melanoma. Alpha-MSH and other neurohormones, as well as neuropeptides including substance P, CGRP, enkephalin, beta-endorphin, and even cellular and molecular agents (mast cells and nitric oxide, respectively), have all been implicated as potential factors in the development, growth, invasion, and dissemination of melanoma in a variety of in vitro and in vivo studies. In this review, we provide an overview of current evidence regarding the intricate effects of neuroendocrine factors in melanoma, including data reported in recent clinical trials, exploring the mechanisms involved, signaling pathways, and the recorded range of effects.

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Action of β-endorphin and nonsteroidal anti-inflammatory drugs, and the possible effects of nonsteroidal anti-inflammatory drugs on β-endorphin

Cited by 18 publications

References 77 publications

IL-10 is associated with increased mu-opioid receptor levels in major depressive disorder

IL-10 is associated with increased mu-opioid receptor levels in major depressive disorder

Effectiveness of low-power laser therapy in improvement of the peripheral neuropathy induced by xenobiotics in rats

Neuroendocrine Factors in Melanoma Pathogenesis

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