Action of Testosterone on the Skin of Aging Male Subjects

Wright, Edwin T.; McGillis, T.J.; Sobel, Harry

doi:10.1159/000252545

Cited by 4 publications

(2 citation statements)

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“…In stark contrast, certain risks of hormone replacement therapy were found to be statistically higher in a meta-analysis of published clinical trials, and patient monitoring was recommended 56. Over 40 years ago, the effects of testosterone injections on the aging male skin were tested, and skin improvements manifested histologically 57. In 2007 and 2010, the intracrine or paracrine actions of sex hormones produced in the skin were reviewed.…”

Section: Discussionmentioning

confidence: 99%

“… 56 Over 40 years ago, the effects of testosterone injections on the aging male skin were tested, and skin improvements manifested histologically. 57 In 2007 and 2010, the intracrine or paracrine actions of sex hormones produced in the skin were reviewed. The paper reports that the androgen receptor densities may have important implications in the development of hyperandrogenism and its associated skin diseases such as acne, seborrhea, hirsutism, and androgenic alopecia.…”

Section: Discussionmentioning

confidence: 99%

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Modulating testosterone pathway: a new strategy to tackle male skin aging?

Bernard¹,

Scior²,

Tuan³

2012

CIA

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In men, the level of testosterone decreases with age. At the skin level, the result is observed as a decrease in density and in a lower elasticity. Identifying compounds that are able to increase the level of testosterone appears to be an attractive strategy to develop new antiaging bioactive ingredients for men. Reverse pharmacognosy was successfully applied to identify new natural compounds able to modulate testosterone levels. Among several in silico hits, honokiol was retained as a candidate as it has the greatest potential to become an active ingredient. This result was then validated in vitro on aromatase and 5-alpha-reductase type 1 and 2, which are two types of enzymes implicated in the degradation of free testosterone. Indeed, honokiol was identified as an inhibitor of aromatase, with a half-maximal inhibitory concentration (IC50) of about 50 μM. In addition, honokiol was shown to be an inhibitor of 5-alpha-reductase type 1, with an IC50 of about 75 μM. Taken together, these data indicate that honokiol modulates testosterone levels, and its structure has the potential to serve as a lead for future designs of highly selective inhibitors of 5-alpha-reductase type 1.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%