1977
DOI: 10.1016/s0074-7696(08)60101-1
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Action of Testosterone on the Differentiation and Secretory Activity of a Target Organ: The Submaxillary Gland of the Mouse

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Cited by 161 publications
(82 citation statements)
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“…The submandibular glands of mice exhibit two distinct secretory compartments, represented by the acini and by the convoluted granular tubules. The acini, which are the terminal portions of the adenomere, consist of seromucous cells, where as the convoluted tubules, which are structure between the intercalated ducts and the striated ducts, consist of serous cells (Jacob, 1959;Raynaud, 1960;Caramia, 1966;Gresik & MacRae, 1975;Chretien, 1977;Pinkstaff, 1980). The convoluted granular tubules are considerably more developed in males than in females, characterizing the marked sexual dimorphism existing in the submandibular glands of these rodents (Lacassagne, 1940;Raynaud, 1960;Chretien, 1977;Pardini, 1985;Jayasinghe, Cope & Jacob, 1990;Sawada & Noumura, 1991;Assis et al , 1994).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The submandibular glands of mice exhibit two distinct secretory compartments, represented by the acini and by the convoluted granular tubules. The acini, which are the terminal portions of the adenomere, consist of seromucous cells, where as the convoluted tubules, which are structure between the intercalated ducts and the striated ducts, consist of serous cells (Jacob, 1959;Raynaud, 1960;Caramia, 1966;Gresik & MacRae, 1975;Chretien, 1977;Pinkstaff, 1980). The convoluted granular tubules are considerably more developed in males than in females, characterizing the marked sexual dimorphism existing in the submandibular glands of these rodents (Lacassagne, 1940;Raynaud, 1960;Chretien, 1977;Pardini, 1985;Jayasinghe, Cope & Jacob, 1990;Sawada & Noumura, 1991;Assis et al , 1994).…”
Section: Discussionmentioning
confidence: 99%
“…We obtained diameters of 49.5 and 36.1 'um for males and females, respectively. The values reported in the literature range from 47.0 to 60.01am and from 31.4 to 40.0ium for males and females, respectively (Lacassagne, 1940;Lacassagne & Chamorro, 1940;Harvey, 1952;Raynaud, 1960;Travill, 1966;Disher, 1967;Chretien, 1977). Gresik & Mac Rae (1975), working with material fixed in glutaraldehyde-osmium and embedded in Epon resin, obtained 120.0 and 80.0 [tm for males and females, respectively.…”
Section: Compartmental Volumetric Dimensionsmentioning
confidence: 99%
“…The epithelial cells of GCT have abundant secretory granules that contain a variety of biologically active peptides, including nerve growth factor (NGF), epidermal growth factor (EGF), transforming growth factor β , renin, and kallikrein (Barka 1980;Gresik 1994). Castration of the animals readily causes involution of the GCT accompanied by conversion of the phenotype of GCT cells into that of striated duct (SD) cells, whereas administration of androgens to females or castrated males causes the opposite phenomenon (Caramia 1966;Chretien 1977). Such androgen-induced GCT differentiation is accompanied by an upregulation of GCT-specifi c gene expression (Gubits et al 1986).…”
mentioning
confidence: 99%
“…The sexual dimorphism of the granular convoluted tubule (GCT) cells of the mouse submandibular gland (SMG) has been repeatedly documented, and a large body of experimental work has established that GCT cells are under the multihormonal control of androgens, thyroid hormones, and adrenocortical hormones (reviewed by Raynaud, 1960;Chrétien, 1977;Young and van Lennep, 1978;Pinksterff, 1980;Gresik, 1994;. Generally, these hormones act as strong promotors of the GCT phenotype, and strong inducers of GCT-specific secretory products, such as EGF (epidermal growth factor), NGF (nerve growth factor), renin, and products of kallikrein gene family members.…”
mentioning
confidence: 99%