Stereological Study of the Sexual Dimorphism in Mouse Submandibular Glands

Pardini, Luiz Carlos; Taga, Rumio

doi:10.2535/ofaj1936.73.2-3_119

Cited by 12 publications

(12 citation statements)

References 16 publications

(17 reference statements)

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“…There have been a number of fine structural studies on the salivary glands of rodents [1,5,[17][18][19]. However, the ultrastructure of the parotid and mandibular glands of the cotton rat have not been reported previously.…”

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confidence: 99%

Fine Structure of the Parotid and Mandibular Glands of the Cotton Rat (Sigmodon hispidus)

et al. 2003

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Abstract:The parotid and mandibular glands of the cotton rat were examined by light and transmission electron microscopy. Parotid gland: Acinar cells were serous in nature, and contained electron-dense granules. Intercalated duct cells contained electron-dense granules. Striated duct cells had small granules of moderate and high electron densities. Mandibular gland: Acinar cells were seromucous in nature, and contained granules of low and moderate electron densities. Intercalated duct cells contained granules of moderate and high electron densities. Striated ducts were comprised of two portions -a secretory portion and a striated portion without granules. The secretory portion had many electrondense granules. A sexual dimorphism was obserbed in these granules, which were smaller and fewer in females than in males.

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Fine Structure of the Parotid and Mandibular Glands of the Cotton Rat (Sigmodon hispidus)

et al. 2003

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“…The IDs constitute Ϸ4% of the parenchymal volume in the rat submandibular gland (Tamarin and Sreebny, 1965) and about the same in the rat parotid gland (percentage calculated from data presented by Jezek et al, 1996); in the rabbit parotid gland they make up Ϸ2.8% of the volume (Cope, 1978). In the sexually dimorphic submandibular glands of laboratory mice, there are no differences in compartmental volumetric density of IDs of males and females (Pardini and Taga, 1996). In the rat submandibular gland, the IDs tend to become hyperplastic with advancing age (Slavin et al, 1990).…”

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Comparative ultrastructure of intercalated ducts in major salivary glands: a review

et al. 1998

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“…Among these methods, stereology has attracted attention due to its sensitivity and precision, permitting the determination of volumetric, superficial, linear and numerical dimensions of different structures and/ or cells present in an organ 1 . In this respect, previous studies carried out in our laboratory using this methodology have permitted, for example, the demonstration that sexual dimorphism in the mouse submandibular gland is not restricted to the convoluted granular tubules but is also present in the acini, intercalated ducts, striated ducts, excretory ducts and stroma 15 ; that no sexual dimorphism is present in the granular or striated ducts of the rat submandibular gland 23 , while sexual differences exist in the acini, intercalated ducts, excretory ducts and stroma 4 ; and that in the mouse parotid gland the acini and intercalated ducts are more developed in males 20 . With respect to the sublingual gland of rodents, evidence for the occurrence of sexual dimorphism detected solely by histochemical methods has only been provided for the mouse 22 and hamster 10 , while no study is available regarding the presence of sexual differences in the rat sublingual gland.…”

Section: Discussionmentioning

confidence: 98%

“…Since the discovery by Lacassagne in 1940 11 that the submandibular gland of the laboratory mouse shows a marked sexual dimorphism characterized by the presence of a larger number of developed convoluted granular tubules in males than in females, this gland has been used as a model for the study of various aspects of secondary sexual differences 5,15,17,18 . Within this line of research, many other studies have been carried out to determine the presence of sexual differences in other major salivary glands of the mouse and, mainly, of other animal species (for a review and references therein, see Pinkstaff 17 ).…”

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confidence: 99%

“…The sublingual glands are the smallest glands among the major salivary glands of the rat 15,21 . These glands are classified as mixed tubuloacinar glands which are predominantly of the mucous type, i.e., most of their terminal secretory units consist of typical mucous cells and are surrounded by relatively few peripheral serous cells forming the serous demilunes 4,6,8,9,17,19,25,26,30 .…”

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confidence: 99%

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Morphometric characterization of sexual differences in the rat sublingual gland

et al. 2004

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ABSTRACT:The presence of morphological differences in the sublingual gland of male and female adult rats was determined by morphometry. Absolute and relative glandular mass was 21% lower and 31% higher, respectively, in females than in males. The fractions of glandular volume occupied by the mixed acini, intercalated ducts and striated ducts did not differ significantly between genders; however, their absolute volume was respectively 29, 42 and 58% higher in males. Despite the differences in the volume of these morphological compartments, the number of cells did not differ significantly between genders, except for the excretory duct compartment, for which a larger number was observed in males. With respect to cell volume, 13, 33 and 47% higher volumes were observed in males for mucous acinar cells and striated and excretory duct cells, respectively, while a 38% higher volume of serous demilune cells was observed for females. The surface-to-volume ratio of acini and striated ducts was respectively 16 and 35% higher in females. Based on these results, we conclude that the sublingual gland of female rats possesses smaller acini, and shorter ducts whose caliber is narrower, smaller mucous acinar and larger serous cells than the ones found in the male gland, indicating the presence of sexual dimorphism as well as suggesting sexual differences in the quality of the secreted product. DESCRIPTORS: Sublingual gland; Rats; Sex characteristics. RESUMO:A ocorrência de diferenças morfológicas entre sexos na glândula sublingual de ratos adultos foi verificada pela morfometria. As massas glandular absoluta e relativa das fêmeas foi, respectivamente, 21% menor e 31% maior que as dos machos. As frações de volume glandular ocupadas pelos ácinos mistos, ductos intercalares e ductos estriados não mostraram diferenças significantes entre sexos, no entanto, os seus volumes absolutos foram, respectivamente, 29%, 42% e 58% maiores nos machos. Apesar dessas diferenças nos volumes compartimentais, os seus conteúdos em número de células não apresentaram diferenças significantes entre sexos, exceto o compartimento dos ductos excretores, que mostrou maior número nos machos. Quanto ao volume celular, as células acinosas mucosas, as dos ductos estriados e as dos ductos excretores mostraram volumes, respectivamente, 13%, 33% e 47% maiores nos machos, e o das células das semiluas serosas foi 38% maior nas fêmeas. A relação superfície-volume dos ácinos e dos ductos estriados foi, respectivamente, 16% e 35% maior nas fêmeas. Baseados nos resultados obtidos, concluímos que as glândulas sublinguais das fêmeas exibem ácinos menores e ductos mais curtos e menos calibrosos e células acinosas mucosas menores e serosas maiores do que nos machos, indicando a ocorrência de dimorfismo sexual, e sugerindo que possa haver também diferenças na qualidade do produto secretado. DESCRITORES: Glândula sublingual; Ratos; Características sexuais. HistologyLima MC, Sottovia-Filho D, Cestari TM, Taga R. Morphometric characterization of sexual differences in the rat su...

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Stereological Study of the Sexual Dimorphism in Mouse Submandibular Glands

Cited by 12 publications

References 16 publications

Fine Structure of the Parotid and Mandibular Glands of the Cotton Rat (Sigmodon hispidus)

Fine Structure of the Parotid and Mandibular Glands of the Cotton Rat (Sigmodon hispidus)

Comparative ultrastructure of intercalated ducts in major salivary glands: a review

Morphometric characterization of sexual differences in the rat sublingual gland

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