1965
DOI: 10.1111/j.1476-5381.1965.tb01794.x
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Action of Sympathomimetic and Allied Amines on the Central Nervous System of the Chicken

Abstract: The effects of the a-methyl derivatives of noradrenaline, phenethylamine and tryptamine on the central nervous system of the chicken have been described (Dewhurst & Marley, 1965a). In the present experiments a larger series of amines and of their amino acid precursors has been tested on the central nervous system and on blood pressure. In addition, factors potentiating activity such as monoamine oxidase inhibition or diminishing activity such as tachyphylaxis or pharmacological antagonism have been studied.Pre… Show more

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Cited by 62 publications
(22 citation statements)
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“…From previous studies with young chickens it appeared that the central excitant sympathomimetic amines such as amphetamine, cyclopentamine, tuaminoheptane and a-methyltryptamine were a homogeneous group despite their variety of chemical structure (Dewhurst & Marley, 1965b). However, the present experiments indicate that amines have additional sites of action because of their effects on temperature and oxygen consumption.…”
Section: Electromyographic Activitycontrasting
confidence: 53%
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“…From previous studies with young chickens it appeared that the central excitant sympathomimetic amines such as amphetamine, cyclopentamine, tuaminoheptane and a-methyltryptamine were a homogeneous group despite their variety of chemical structure (Dewhurst & Marley, 1965b). However, the present experiments indicate that amines have additional sites of action because of their effects on temperature and oxygen consumption.…”
Section: Electromyographic Activitycontrasting
confidence: 53%
“…The catecholamines adrenaline, noradrenaline and the a-methyl derivatives given intravenously lowered core and surface temperatures. These amines raise blood pressure in chickens (Dewhurst & Marley, 1965b) and the associated vasoconstriction would hinder heat loss. The effects of the a-methyl derivatives of adrenaline and noradrenaline were the most consistent, and were dose-dependent.…”
Section: Electromyographic Activitymentioning
confidence: 99%
“…In contrast, NA exhibited no apparent excitatory actions but did cause behavioural depression. These observations agree with those of Dewhurst & Marley (1965) was greatly prolonged. At higher doses, which by themselves caused behavioural alerting, tryptamine reduced the duration of the 5-HT-induced depression.…”
Section: Discussionsupporting
confidence: 82%
“…(3) 5-HT-induced behavioural depression in young chicks. Since young chicks lack a mature blood-brain barrier (Lajtha, 1957), the behavioural effects seen following systemic administration of 5-HT are probably due to an action of the amine on central receptors (Dewhurst & Marley, 1965). The effects of tryptamine on these manifestations of the central actions of 5-HT have been studied.…”
Section: Introductionmentioning
confidence: 99%
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