Action of Sucrose Polyesters on Lipid Metabolism in Rats

Aust, L.; Brückner, J.; Proll, J.; Noack, R.; Mieth, G.

doi:10.1159/000176503

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…Knowledge of nonnutritional factors found in ether lipids has been extended to nonfattening fats that are made from fully esterified sorbitol and sucrose. They appear to be the compounds most suitable for use as nonfattening fats (88,89).…”

Section: Ether Lipids In the Diet Of Humansmentioning

confidence: 99%

Ether lipids based on the glyceryl ether skeleton: Present state, future potential

Urata

Takaishi

1996

J Americ Oil Chem Soc

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Lipids from natural sources consist mainly of saponifiable substances, such as glycerides, along with some unsaponifiable lipids, some of which are ether lipids. Typical ether lipids are monoalkyl ethers of glycerin, also called alkyl/alkenyl glyceryl ethers. Alkyl/alkenyl glyceryl ethers have also been reported in marine organisms and in human feces. Several chemical syntheses of such ether [ipids have been reported. Typical examples are alkyl glyceryl ether formation by the addition reaction of alkyl glycidyl ether and the telomerization reaction of butadiene with glycerin and a transition metal catalyst. Characteristic chemical structures, such as terpene alkyl glyceryl ethers, archaebacterial macrocyclic ether lipids, and glyceryl ethers of condensed cyclic planar molecules, have been obtained as well. Over the past few decades, industry has shown much interest in the chemistry and application of highly branched fatty acids. For example, isostearyl glyceryl ether (GE-IS) with methyl branching in the middle chain was already known, but it is now prepared at an industrial scale by proprietary alkyl glycidyl ether methods. The characteristic behavior of GE-IS toward water, such as formation of water-in-oil emulsions containing large amounts of water and of liquid crystals, has made it applicable for use in hair and skin care cosmetics. Based on these studies and considerations, glycery[ ether lipids, which are rarely investigated, may become one of the most important and useful lipids in the industry. JAOCS 73, 819-830 (1996). KEY WORDS:Ether lipids, GE-IS, glyceryl ether, glycidyl ether, isostearic acid, isostearyl glyceryl ether, liquid crystal, W/O emulsion.Saponification of lipids from tissues and organs of many marine animals results in water-soluble soaps that have high levels of some unsaponifiable substances, which chiefly include hydrocarbons, such as squalene, sterols, and long-chain alcohols with one or more hydroxyl groups (1,2). Typical longchain alcohols that contain one or more hydroxyl groups are particularly present as monoalkyl ethers of glycerin:RO-CH2-CH-CH 2 cyl glycerol, and batyl alcohol as the major constituents in a mixture of free alkyl glyceryl ethers isolated from the sponge Desmapsamma anchorata, harvested in the Gulf of Mexico, and minor components consisted of Cls, Cl9, C20, and Czl alkyl glyceryl ethers (12). They also found that sponges such

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Section: Ether Lipids In the Diet Of Humansmentioning

confidence: 99%

Ether lipids based on the glyceryl ether skeleton: Present state, future potential

Urata

Takaishi

1996

J Americ Oil Chem Soc

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“…Die Cholesterol-und Fettsauresynthese wird dabei iiber das innerhalb von 2 h iiikorporierte Acetat (nmol pro g Leber) erfa5t. Cholesterol wurde dabei nach Verseifung der Leberschnitte rnit 5 Was die Sucro-Aceto-Glyceride anlangt, so bestehen diese im Gegensatz zu den bereits eingehender untersuchten Saccharose-Fettsaure-Polyestern neben Triglyceriden hauptsachlich aus Saccharose-Polyestern mit Essigsaure und Fettsaure als konstituierende Strukturelemente [ 171. ErwartungsgemaB resultieren bei ihrer Applikation infolge des geringeren effektiven Energieinhaltes der Nahrung eine verminderte Futtereffizienz und KKrpergewichtszunahme, deren AusmaB dem Anteil an nichtspaltbaren Saccharose-Polyestern proportional ist.…”

Section: T R I E F H J~/ E N G L Y C O / -D I -~O~e C~/ E~f E R Herunclassified

“…Bestatigt wurde die Senkung des Triglycerid-und Cholesterolspiegels in der Leber in der bekannten GroBenordnung, nicht aber darin eine Steigerung der Cholesterolsynthese. Im Gegensatz zu Ergebnissen an Menschen [ 191 und Affen [20], aber in Ubereinstimmungmit den eigenen friiheren Untersuchungen [5] Die markantesten metabolischen Auswirkungen, die uber die rein akalorischen Effekte der iibrigen Pseudofette hinausgehen, betreffen langkettige Polyglycol-Ether als Strukturanaloga von Alkoxy-Glyceriden. Obwohl die gleiche fakale Exkretionsrate wie bei Polyglycerol-Fettsaureestern ermittelt wurde, ist die Depression der Korpermasseentwicklung bei den Versuchstieren erheblich starker ausgepragt.…”

Section: T R I E F H J~/ E N G L Y C O / -D I -~O~e C~/ E~f E R Herunclassified

Orientierende Untersuchungen zum Stoffwechsel verschiedenartiger akalorischer Verbindungen mit fettähnlichen Eigenschaften bei der Ratte

Aust

Mieth

Proll

et al. 1988

Nahrung

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Pseudofats as total substituted long-chain esters and ethers of polyhydroxyl compounds (sucrose, triglycerol, and polyethyleneglycol) are more or less indifferent against gastrointestinal enzymes, but display specific metabolic effects on lipid metabolism especially on cholesterol synthesis in liver, plasma lipid level, and fecal cholesterol excretion. Among the different tested compounds there exist similarities as well as differences, which are to consider as an indication for a specific relationship between structure and effect. These relations are more closely investigated and critically discussed.

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“…Their application leads to an increase of fecal cholesterol excretion. which is accompanied by a significant stimulation of the cholesterol synthesis in the liver and partly by a reduction of the lipid level in serum [3,4). SPE are consequently potential substitutes for dietary 1ats in foodstoffs to reduce energy intake and the serum lipid level [5.…”

mentioning

confidence: 99%

Oxidation and accumulation of sucrose polyesters after i.v. application in rats (Short communication)

Aust

Schliemann

Proll

et al. 1988

Nahrung

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Short communication) I-. AUST, 11. SCHLIEMANN, J. PROLL and G. MIETHPolyester of sucrose and longchain fatty acids (SPE) are prototyps of unabsorbable compounds with fatlike physico-chemical properties [ 1, 21. Their application leads to an increase of fecal cholesterol excretion. which is accompanied by a significant stimulation of the cholesterol synthesis in the liver and partly by a reduction of the lipid level in serum [3,4). SPE are consequently potential substitutes for dietary 1ats in foodstoffs to reduce energy intake and the serum lipid level [5. 61. Earlier animal experiments with 64; '*C-labelled sucrose-octa-palmitate in a semisynthetic diet, however, outlined a very small but not neglectable accumulation raie of lO.-'--lO -5 0 ; in various organs after a feeding time of 7 days or 3 and 6 weeks, respectively [7,8).Because nothing is known about metabolic fate of incorporated SPE the study aimed at the elucidation of the metabolic behaviour of SPE after i.v. injection to mimic a higher accumulation rate.

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Action of Sucrose Polyesters on Lipid Metabolism in Rats

Cited by 7 publications

References 18 publications

Ether lipids based on the glyceryl ether skeleton: Present state, future potential

Ether lipids based on the glyceryl ether skeleton: Present state, future potential

Orientierende Untersuchungen zum Stoffwechsel verschiedenartiger akalorischer Verbindungen mit fettähnlichen Eigenschaften bei der Ratte

Oxidation and accumulation of sucrose polyesters after i.v. application in rats (Short communication)

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