Action of ethanol and limontar during antenatal development on lipid peroxidation and on the antioxidant protection system in the brain and liver tissue of fetal and neonatal rats

The pharmacological potential ofSorbus commixtacortex on blood alcohol concentration and hepatic lipid peroxidation in acute alcohol-treated rats

“…In several previous studies, it has been also reported that catalase activity was reduced in acute alcohol-treated rats, suggesting that the reduced activity was due to oxidative inactivation by ROS generated from alcohol metabolism or inhibition by elevated influx of superoxides, a catalase inhibitor (Pigeolet et al 1990;Schlorff et al 1999). Our results are consistent with the findings of Bykova & Zhukova (1991), Dinu & Zamfir (1991) and Husain & Somani (1997), who reported decreased catalase activity in the liver of alcohol-treated rats. Based on these findings, catalase appears to be used as an antioxidant defence enzyme to catalyse H 2 O 2 decomposition rather than as an alcohol oxidizing enzyme in this experiment as well.…”