The pharmacological potential ofSorbus commixtacortex on blood alcohol concentration and hepatic lipid peroxidation in acute alcohol-treated rats

Abstract

The effect of Sorbus commixta cortex, a traditional herbal medicine used for the treatment of bronchitis, gastritis and dropsy, on blood alcohol concentration (BAC) and hepatic lipid peroxidation was examined in acute alcohol-treated rats. A 30-min pretreatment with a methanol extract of S. commixta cortex (SC) at concentrations higher than 200 mg kg(-1) resulted in a significant decrease in BAC and the ethyl acetate fraction (SE) of the extract showed the highest potency, with a maximum of a 46% decrease at 150 mg kg(-1) 2 h after alcohol administration (3.0 g kg(-1)) compared with the control group (P < 0.005). The rapid reduction in BAC did not appear to be due to the protection or activation of hepatic alcohol dehydrogenase (ADH) activity by SE. Hepatic malondialdehyde (MDA) levels were significantly increased by acute alcohol administration within 6 h, although pretreatment with the SE caused a significant decrease in MDA levels compared with alcohol treatment alone. Hepatic glutathione (GSH) levels and superoxide dismutase (SOD) activity remained unchanged by alcohol, SE alone or by the combined treatment of alcohol and SE. However, catalase activity was significantly reduced by acute alcohol administration and pretreatment with the SE led to significant protection of its activity. These results suggest that pretreatment with SE reduces hepatic lipid peroxidation by decreasing the bioavailability of alcohol and its oxidative metabolites, such as H2O2, at least partly, through the protection of hepatic catalase in acute alcohol-treated rats.

Bioactive Components and Antioxidant Capacity of Fruits from Nine Sorbus Genotypes

“…Rowanberry fruits are used in the management of various diseases such as intestinal obstructions, chronic diarrhea, coronary heart diseases, different types of cancer (Fan and others ), long‐term diabetic complications (Termentzi and others ), liver, and gallbladder conditions and the prevention of inflammation (Yu and others ; Hong and others ). Additionally, through the protection of hepatic catalase, these fruits reduce hepatic lipid peroxidation by decreasing the bioavailability of alcohol and its oxidative metabolites (Lee and others ).…”

Inhibition of protein tyrosine phosphatase 1B by lupeol and lupenone isolated from Sorbus commixta

“…In our previous work, the flavanol glycosides, catechin-7-O--D-xylopyranoside and catechin-7-O--D-apiofuranoside, isolated from this species, were found to have antioxidant activity [9]. Recently, its extract was demonstrated to have beneficial effects on atherosclerosis and protective effect on hepatic lipid peroxidation in acute-alcohol treated model [10,11]. However, there has been no study with regard to its inhibitory effect on PTP1B.…”

Variation in the Contents of Neochlorogenic Acid, Chlorogenic Acid and Three Quercetin Glycosides in Leaves and Fruits of Rowan (Sorbus) Species and Varieties from Collections in Lithuania

“…Ethanol extracts of S. commixta bark have photoprotective effects [9]. Experiments with rats pretreated with methanol extracts of S. commixta cortex revealed antitoxic effects of the extracts [10]. It was found that methanol and butanol extracts of S. commixta cortex have vasodilating properties [11,12], while methanol extracts have antiatherogenic effects [13,14].…”