Action of different monoterpenic compounds against Anisakis simplex s.l. L3 larvae

In vitro larvicidal activity of geraniol and citronellal against Contracaecum sp (Nematoda: Anisakidae)

“…The use of other monoterpene compounds has been investigated, such as eugenol against Caenorhabiditis elegans (20), showing a larvicidal effect with an ED 50 of 62.1 μg/mL. Other investigators evaluated the effect of eugenol against Anisakis simplex larvae but did not obtain a larvicidal effect at the maximum concentration tested of 12.5 μg/mL (13). Although the effect of eugenol against Contracaecum sp larvae has not been tested, with these results we can observe that, even though monoterpene compounds have been described as anthelminthics, the dose of the product tested and the sensitivity of the helminth species directly influenced the results.…”

“…This compound was later used for the in vitro evaluation of its effect against Anisakis simplex (13), showing a significant larvicidal ef- To identify the best regression model, the F-test was used. The equation y = 7.33297 + 1.899925x, where y = mortality (%) and x = time (h), was obtained by the minimum-squares method (R 2 = 0.8926).…”

“…Pharmacological treatments have been suggested (11) but are not commonly used in clinical practice. The use of monoterpene compounds in vitro and in vivo has shown a significant anti-helminthic activity (12)(13)(14)(15), presenting also phytotoxic (16) and acaricidal activities (17). The objective of the present study was to evaluate the anti-helminthic activity of the terpenic compounds geraniol and citronellal against Contracaecum sp larvae.…”

Methylcrotonyl-CoA and geranyl-CoA carboxylases are involved in leucine/isovalerate utilization (Liu) and acyclic terpene utilization (Atu), and are encoded by liuB/liuD and atuC/atuF, in Pseudomonas aeruginosa

“…Citronellol and geraniol are of industrial interest due to their commercial use in the food (flavour) and perfume (odour) industries. Moreover, citronellol is one of very few naturally occurring repellents of insects (mosquitoes) (Hierro et al, 2004;Pawar et al, 1991;Rice & Coats, 1994). Geraniol is structurally related to citronellol, and differs only by the presence of an additional double bond.…”

Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis

“…a P ≤ 0.05 compared to the CO group (Student t-test for unpaired data). Dietary isoprenoids such as βI and GO have been shown to have antioxidant properties (14,24,38). Treatment with these isoprenoids, individually or in combination, reduced DNA damage although only GO exhibited anticarcinogenic effects.…”