Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis

Vieira, Antônio Wilson; Heidor, Renato; Cardozo, M.T.; Scolastici, C.; Purgatto, E.; Shiga, T.M.; Barbisan, L.F.; Ong, Thomas Prates; Moreno, Fernando Salvador

doi:10.1590/s0100-879x2011000600007

Cited by 37 publications

(8 citation statements)

References 17 publications

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“…Several studies assign potent cytotoxic effect of monoterpenes, including geraniol, on tumor cells (Bakkali et al, 2008;Vieira et al, 2011;Crespo et al, 2013;Sobral et al, 2014;Lee et al, 2016). Considering that HepG2 is a cell line derived from the liver tumor, the noted reduction in the percentage of viable cells for the concentration of 10 µg/mL geraniol onwards, might, therefore, be justified, once the same cytotoxicity pattern was not obtained when used normal cells.…”

Section: Discussionmentioning

confidence: 99%

Research Article Cytotoxic and genotoxic potential of geraniol in peripheral blood mononuclear cells and human hepatoma cell line (HepG2).

et al. 2017

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ABSTRACT. Geraniol is an acyclic monoterpene alcohol present in the essential oil of many aromatic plants and is one of the most frequently used molecules by the flavor and fragrance industries. The literature also reports its therapeutic potential, highlighting itself especially as a likely molecule for the development of drugs against cancer. In view of these considerations, this study was designed to evaluate the cytotoxic and genotoxic potential of geraniol, in an in vitro protocol, using two types of human cells: one without the ability to metabolize (peripheral blood mononuclear cells -PBMC), and the other with this capability (human hepatoma cell line -HepG2) through the comet assay and the micronucleus test. Four concentrations (10, 25, 50, and 100 µg/ mL) were selected for the genotoxic assessment for PBMC and three (1.25, 2.5, and 5 µg/mL) for HepG2 cells based on cytotoxicity tests (MTT assay). Results showed that geraniol did not present genotoxic or clastogenic/aneugenic effects on both cell types under the conditions studied. However, caution is advised in the use of this substance by humans, since a significant reduction in viability of HepG2 and a marked decrease in cell viability on normal PBMC were verified.

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Section: Discussionmentioning

confidence: 99%

Research Article Cytotoxic and genotoxic potential of geraniol in peripheral blood mononuclear cells and human hepatoma cell line (HepG2).

et al. 2017

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“…As limonene, geraniol shows interesting anticancer properties (Crowell, ). The efficacy of geraniol has been demonstrated by numerous studies in vitro and in vivo on many cancers including prostate (Kim et al , ), kidney (Ahmad et al , ), liver (Cardozo et al , ; Ong et al , ; Polo et al , ), colon (Carnesecchi et al , ; Carnesecchi et al , ; Carnesecchi et al , ; Vieira et al , ), pancreas (Burke et al , ; Wiseman et al , ), breast (Duncan et al , ), mouth (Vinothkumar and Manoharan, ), and skin (Yu et al , ). Geraniol at 100 µ m induced an inhibition of proliferation in cultured cells of colon cancer (Carnesecchi et al , ) and reduced tumor volume by 26% with 150 mg/kg (Carnesecchi et al , ).…”

Section: Anticancer Action Of Terpenic and Aromatic Compounds In Vitrmentioning

confidence: 99%

Anticancer Activities of Essential Oils Constituents and Synergy with Conventional Therapies: A Review

Lesgards

Baldovini

Vidal

et al. 2014

Phytotherapy Research

129

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Many studies have shown that a large number of terpenoids and aromatic compounds contained in essential oils have significant anticancer activities, both on cell lines and on tumors in animals. The activity of these constituents is related to the activation of cell death (apoptosis) induced by the caspases proteins in cancer cells, with minor modifications of healthy cells. Many phenomena seem to occur, among which are as follows: overexpression and regulation of liver detoxification enzymes, changes in the membrane potential of cancer cells and mitochondria, production of free radicals in cancer cells, inhibition of angiogenesis, and modification of tumor-inducing genes. These active essential oil constituents appear to act synergistically with conventional chemotherapy and radiotherapy, and some clinical studies in humans are beginning to be realized. In this review, we discuss about the antitumoral activity of 13 essential oil components selected among the most studied in the literature, with a focus on their possible mode of action. We also report current data on the anticancer properties of several total essential oils.

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“…Geraniol (Ger), a natural acyclic monoterpene alcohol, is the main component of oils of rose, palmarosa [18] and several essential oils, such as ginger, lemon, orange, and nutmeg [19]. Ger possesses miscellaneous pharmacological effects, being an antioxidant [20], antimicrobial [21], anti-inflammatory, antiapoptotic [18], antitumor [22] and a 3-hydroxy3-methylglutaryl co-enzyme-A (HMG-CoA) reductase inhibitor, which is the feasible antitumor mechanism of Ger [23].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Geraniol ameliorates TNBS-induced colitis: Involvement of Wnt/β-catenin, p38MAPK, NFκB, and PPARγ signaling pathways

2015

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Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis

Cited by 37 publications

References 17 publications

Research Article Cytotoxic and genotoxic potential of geraniol in peripheral blood mononuclear cells and human hepatoma cell line (HepG2).

Research Article Cytotoxic and genotoxic potential of geraniol in peripheral blood mononuclear cells and human hepatoma cell line (HepG2).

Anticancer Activities of Essential Oils Constituents and Synergy with Conventional Therapies: A Review

Geraniol ameliorates TNBS-induced colitis: Involvement of Wnt/β-catenin, p38MAPK, NFκB, and PPARγ signaling pathways

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