ACTION OF CERTAIN SULFONAMIDES AND OF THIOUREA UPON THE FUNCTION OF THE THYROID GLAND OF THE RAT<sup>1</sup>

Astwood, E. B.; Sullivan, Jason P.; Bissell, Adele; Tyslowitz, R.

doi:10.1210/endo-32-2-210

Cited by 220 publications

(33 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Antithyroid drugs and iodine deficiency produce hypertrophy and hyperplasia of the thyroid in experimental animals (Remington et al, 1937;Astwood et al, 1943;MacKenzie and MacKenzie, 1943), and involution is induced by discontinuing the drugs and refeeding a high-iodine diet (Wollman and Breitman, 1970). Althoug thyroid hypertrophy and hyperplasia following goitrogen treatment are evidently responses to the excessive secretion of TSH, some factors are known to modify the goitrogenic action of this pituitary hormone.…”

mentioning

confidence: 99%

Thyroid function and polyamines. III. Changes in ornithine decarboxylase activity and polyamine contents in the rat thyroid during hyperplasia and involuton.

et al. 1978

View full text Add to dashboard Cite

SynopsisChanges in ornithine decarboxylase (ODC) activity and in polyamine contents of the rat thyroid were studied under various experimental conditions. Methylthiouracil (MTU) treatment produced several-fold increases in the thyroid ODC activity and in the content of putrescine, spermidine and spermine within a week. While serum thyrotropin (TSH) levels increased gradually up to 3 weeks, the content of both putrescine and spermidine tended to reach a plateau after 2 weeks of the goitrogen treatment;spermine content continued to increase progressively for 3 weeks. Discontinuance of MTU at 7 days resulted in a rapid decline in the elevated thyroid ODC activity, followed by a diminution of putrescine, spermidine and RNA contents. Thyroidal putrescine, spermidine and RNA responded more sensitively to both introduction and withdrawal of TSH stimulation than thyroidal spermine and DNA.Excess iodide, having no effect on the basal level of thyroid ODC, suppressed the MTU-induced increase in this enzyme activity without affecting circulating TSH, thyroxine (T4) and triiodothyronine (T3) levels. There was a significant negative correlation between the ODC activity and intrathyroidal concentration of iodine in MTUpretreated rats. Theophylline increased the thyroid weight and ODC activity when given to rats fed with a subeffective dose of MTU. Analyses of serum TSH, T4, T3 and of thyroidal iodine revealed that TSH-induced thyroid ODC activity was suppressed by increased circulating thyroid hormones and/or intrathyroidal iodine. Furthermore, it was suggested that thyroid hormones and excess iodide acted directly on the thyroid to alter polyamine biosynthesis, possibly by changing the responsiveness of the gland to TSH.The polyamines, spermidine and spermine and their precursor putrescine, occur ubiquitously in living organisms. The fact that polyamines are found at high concentrations in rapidly growing tissues suggests that these biogenic amines play an important role in the regulation of growth processes (

show abstract

mentioning

confidence: 99%

Thyroid function and polyamines. III. Changes in ornithine decarboxylase activity and polyamine contents in the rat thyroid during hyperplasia and involuton.

et al. 1978

View full text Add to dashboard Cite

show abstract

“…12) schowsky's (1944,1945) hyperplasia. This is the accepted mechanism for the goitrogenic action of antithyroid'drugs, such as thiouracil (Astwood, Sullivan, Bissell and Tyslowitz, 1943 ;Mackenzie and Mackenzie, 1943). The experimentally produced adenomas can be regarded as representing focal (nodular) hyperplasia.…”

Section: Res'ultsmentioning

confidence: 99%

The Effect of Radioactive Iodine Alone and in Combination with Methylthiouracil and Acetylaminofluorene upon Tumour Production in the Rat's Thyroid Gland

Doniach¹

1950

Br J Cancer

View full text Add to dashboard Cite

“…If the administration has been continued long enough, a diminution of circulating thyroxine will occur, and an excessive output of thyrotropic hormone by the pituitary gland will have resulted (66,67). The thyroid gland, under these circumstances, is found to be grossly enlarged, hyperplastic microscopically, and hyperactive as judged by the increased capacity to concentrate radioactive iodide (26).…”

Section: Organic Binding and Hormone Synthesismentioning

confidence: 99%

The Use of Radioiodine in Physiological and Clinical Studies on the Thyroid Gland

Raben¹,

Astwood²

1949

J. Clin. Invest.

View full text Add to dashboard Cite

ACTION OF CERTAIN SULFONAMIDES AND OF THIOUREA UPON THE FUNCTION OF THE THYROID GLAND OF THE RAT¹

Cited by 220 publications

References 1 publication

Thyroid function and polyamines. III. Changes in ornithine decarboxylase activity and polyamine contents in the rat thyroid during hyperplasia and involuton.

Thyroid function and polyamines. III. Changes in ornithine decarboxylase activity and polyamine contents in the rat thyroid during hyperplasia and involuton.

The Effect of Radioactive Iodine Alone and in Combination with Methylthiouracil and Acetylaminofluorene upon Tumour Production in the Rat's Thyroid Gland

The Use of Radioiodine in Physiological and Clinical Studies on the Thyroid Gland

Contact Info

Product

Resources

About

ACTION OF CERTAIN SULFONAMIDES AND OF THIOUREA UPON THE FUNCTION OF THE THYROID GLAND OF THE RAT1

Cited by 220 publications

References 1 publication

Thyroid function and polyamines. III. Changes in ornithine decarboxylase activity and polyamine contents in the rat thyroid during hyperplasia and involuton.

Thyroid function and polyamines. III. Changes in ornithine decarboxylase activity and polyamine contents in the rat thyroid during hyperplasia and involuton.

The Effect of Radioactive Iodine Alone and in Combination with Methylthiouracil and Acetylaminofluorene upon Tumour Production in the Rat's Thyroid Gland

The Use of Radioiodine in Physiological and Clinical Studies on the Thyroid Gland

Contact Info

Product

Resources

About

ACTION OF CERTAIN SULFONAMIDES AND OF THIOUREA UPON THE FUNCTION OF THE THYROID GLAND OF THE RAT¹