The Effect of Radioactive Iodine Alone and in Combination with Methylthiouracil and Acetylaminofluorene upon Tumour Production in the Rat's Thyroid Gland

Doniach, I.

doi:10.1038/bjc.1950.22

Cited by 78 publications

(5 citation statements)

References 3 publications

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“…In contrast, for example, to that of gut and breast, the thyroid follicular epithelium can be regarded from a differentiation and cell kinetic standpoint as a single homogeneous population whose growth is regulated in vivo by a single major growth factor -thyroid stimulating hormone, TSH (Dumont, 1971). A spectrum of benign and malignant epithelial tumours occurs spontaneously in man and can be induced experimentally in rodents by a sustained high level of serum TSH alone (as well as by chemical carcinogens or irradiation) (Doniach, 1950). The in vivo organisation of thyroid epithelial cells in discrete follicles facilitates their isolation by differential sedimentation to give primary cultures free from stromal cells (Smith et al, 1986).…”

mentioning

confidence: 99%

Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T

Burns

Lemoine²,

Nr³

et al. 1989

Br J Cancer

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mentioning

confidence: 99%

Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T

Burns

Lemoine²,

Nr³

et al. 1989

Br J Cancer

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“…Tumours of thyroid follicular cells can be induced in experimental animals in a number of ways, including goitrogen administration (Griesbach et al 1945;Bielschowsky 1949;Purves 8c Griesbach 1947;Morris et al 1951), partial thyroidectomy (Doniach 8c Williams 1962) and irradiation (Doniach 1953(Doniach , 1974. A combination of two of these factors has been shown to produce more tumours than one alone, and Hall (1943) put forward the two stage hypothesis of thyroid carcinogenesis in which radiation was considered the mutagenic agent and TSH was required to promote tumour development.…”

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confidence: 99%

Experimental Carcinogenesis in the Rat Thyroid Follicular and C Cells

Triggs

Williams

1977

European Journal of Endocrinology

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It is known that tumours of several endocrine glands can be induced by a combination of a physiological stress and radiation. It was decided to assess the effect of radiation and of changes in dietary calcium on the development of thyroid tumours in the rat. Three hundred rats were given either 0, 5 or 10 \g=m\Ci of 131I in their first day of life. Each of these groups was subdivided after weaning, and maintained on a diet that was either high, normal or low in calcium. The animals were killed at intervals up to 27 months of age, and the numbers of thyroid tumours recorded. Follicular tumours were first noted at 9 months of age, and their frequency increased steadily with age. The effect of radiation was highly significant, only one tumour occurred in a non-irradiated animal. There was a small increase in frequency in follicular tumours in the high calcium diet group as compared to the low calcium diet group. C cell tumours were first noted at 9 months of age, and their incidence again increased with age. Significantly more tumours occurred in the radiated than in the non-irradiated animals. No significant variation occurred in relation to dietary calcium. It is concluded that an increase in dietary calcium, known to be mildly goitrogenic, may also be important in the carcinogenesis of follicular but not C cell tumours, and that radiation, known to be carcinogenic for thyroid follicular cells is also carcinogenic for C cells.

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“…During the 1950s thyroid carcinoma was experimentally induced in the rat by radioactive iodine (RI), and a causal relation between RI and thyroid carcinoma was suggested [1][2][3]. With regard to RI therapy for Graves' disease and the subsequent occurrence of thyroid carcinoma, Chapman and Maloof [10] found no case of thyroid carcinoma attributable to RI in a series of 585 patients with Graves' disease treated at the Massachusetts General Hospital during a 12-year period.…”

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Thyroid carcinoma after radioactive iodine therapy for Graves' disease

et al. 1994

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Although the causal relation between radioactive iodine therapy (RIT) for Graves' disease and the subsequent occurrence of thyroid carcinoma is not definite, surgeons may be faced with the treatment of such patients. We studied the clinicopathologic features of patients with thyroid carcinoma following RIT for Graves' disease. From January 1983 to December 1991, 11 patients with thyroid carcinoma occurring 1 year or more after RIT for Graves' disease underwent surgery at Ito Hospital. These 11 patients accounted for 0.51% of 2146 surgical cases of thyroid carcinoma and 0.17% of 6419 RIT cases of Graves' disease during the period. They were all women, and their mean ages at RIT and surgery were 44.3 and 51.4 years, respectively. The administered dose of RI was 222.1 MBq and the absorbed dose 45.3 Gy on average. Total thyroidectomy was performed in two patients, subtotal thyroidectomy in three, and lobectomy in six. Bilateral modified neck dissection (MND) was added in two patients, and ipsilateral MND in seven. Histology revealed 10 papillary and 1 follicular carcinoma. The mean diameter of the tumor was 18.5 mm. Intraglandular dissemination of the tumor was noted in only one case and solid growth pattern in two. Nodal metastasis was disclosed in six cases, but in five of them only one node was involved. The present study indicated that thyroid carcinoma occurring after RIT for Graves' disease is not an aggressive variety, and thyroid lobectomy with ipsilateral MND would be sufficient as surgical treatment for such patients.

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The Effect of Radioactive Iodine Alone and in Combination with Methylthiouracil and Acetylaminofluorene upon Tumour Production in the Rat's Thyroid Gland

Cited by 78 publications

References 3 publications

Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T

Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T

Experimental Carcinogenesis in the Rat Thyroid Follicular and C Cells

Thyroid carcinoma after radioactive iodine therapy for Graves' disease

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