Action of Acetazolamide in Ménière's Disease

Varga, G; Ribári, O

doi:10.1017/s0022215100158815

Cited by 10 publications

(2 citation statements)

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“…These encouraging reports of the efficacy of acetazolamide in the management of glaucoma not unnaturally led to its introduction as a medical treatment for Meniere's disease. Several papers soon described symptomatic improvement in patients with Meniere's disease (Corvera, 1956;Muftic, 1957;Varga and Ribari, 1958;Varga et al, 1966). These reports gave inadequate details of the patients under study, and paid little attention to the important aspect of disease staging.…”

Section: Discussionmentioning

confidence: 99%

“…Several previous clinical reports have described symptomatic improvement in patients with Meniere's disease following oral administration of acetazolamide, a carbonic anhydrase inhibitor and mild diuretic (Corvera, 1956;Muftic, 1957;Varga and Ribari, 1958;Varga et al, 1966). These reports, however, have generally been of a limited and anecdotal nature.…”

Section: Introductionmentioning

confidence: 99%

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Oral acetazolamide in Menière's disease

Brookes¹,

Booth²

1984

J. Laryngol. Otol.

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The therapeutic efficacy of oral acetazolamide has been evaluated in a small pilot study of 14 patients with Menière's disease (23 hydropic ears). Symptomatic improvement was found in 4 cases. In 2 of these patients the improvement was not sustained, whilst another had to stop the drug due to the development of bilateral renal calculi. A deterioration in symptoms was seen in 3 cases. Significant adverse side-effects were encountered in 6 of the 13 patients (46.2 per cent) who complied with drug dosage instructions. It is suggested that this high incidence of side-effects may be consistent with a general metabolic difference between Menière's patients and normal subjects. We conclude that oral acetazolamide has no place in the medical treatment of Menière's disease.

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Section: Discussionmentioning

confidence: 99%