Actinic prurigo in Scandinavian adolescent successfully treated with cyclosporine A

Sitek, Jan Cezary

doi:10.4081/dr.2017.7050

Cited by 4 publications

(3 citation statements)

References 7 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although rare in Caucasians with only a few instances from Australia, Britain and France, the disease is well-known among Native Americans and in Central and South America. [ 54 ]…”

Section: Discussionmentioning

confidence: 99%

A Review on Sun Exposure and Skin Diseases

Merin¹,

Shaji²,

Kameswaran³

2022

Indian Journal of Dermatology

View full text Add to dashboard Cite

Skin is the thin layer of tissue forming the natural integumentary system of the body that acts as a barrier to protect it from exogenous and endogenous factors that induce undesirable biological responses in the body. Among these risk factors, skin damage triggered by solar ultraviolet radiation (UVR) is an escalating problem in dermatology with an increased incidence of acute and chronic cutaneous reactions. Several epidemiological studies have provided evidence for both beneficial and harmful effects of sunlight, particularly the solar UVR exposure of human beings. Due to overexposure to solar UVR on the earth's surface, outdoor professionals such as farmers, rural workers, builders and road workers are most vulnerable to developing occupational skin diseases. Indoor tanning is also associated with increased risks for various dermatological diseases. Sunburn is described as the erythematic acute cutaneous response in addition to increased melanin and apoptosis of keratinocytes to prevent skin carcinoma. Alterations in molecular, pigmentary and morphological characteristics cause carcinogenic progression in skin malignancies and premature ageing of the skin. Solar UV damage leads to immunosuppressive skin diseases such as phototoxic and photoallergic reactions. UV-induced pigmentation persists for a longer time, called long-lasting pigmentation. Sunscreen is the most mentioned skin protective behaviour and it is the most promoted part of the sun smart message along with other effective skin protection strategies such as clothing, that is, long sleeves, hats and sunglasses.

show abstract

“…Although rare in Caucasians with only a few instances from Australia, Britain and France, the disease is well-known among Native Americans and in Central and South America. [ 54 ]…”

Section: Discussionmentioning

confidence: 99%

A Review on Sun Exposure and Skin Diseases

Merin¹,

Shaji²,

Kameswaran³

2022

Indian Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…Photoprotective strategies, topical corticosteroids, and antihistamines rarely achieve adequate symptomatic control. Thalidomide and cyclosporine can be effective, but side effects limit their use 2,3 …”

Section: Discussionmentioning

confidence: 99%

“…Thalidomide and cyclosporine can be effective, but side effects limit their use. 2,3 Actinic prurigo is a type IV hypersensitivity reaction, but the exact mechanistic pathway is unknown. Ultraviolet light liberates TNF-α from keratinocytes triggering the Th1 cell-mediated inflammatory pathway resulting in apoptosis, which forms the rationale for thalidomide therapy.…”

Section: A S Ementioning

confidence: 99%

Clearance of pediatric actinic prurigo with dupilumab

Eickstaedt

Starke

Krakora

et al. 2020

Pediatric Dermatology

View full text Add to dashboard Cite

show abstract

Cutaneous Photosensitivity Diseases

Ibbotson

2024

Rook's Textbook of Dermatology

View full text Add to dashboard Cite

The photodermatoses are a diverse group of conditions in which abnormal responses to light exposure are the hallmark. Photodiagnostic investigations through a specialist unit may be essential to ensure accurate diagnosis and management, and this chapter explores the nature of the photodermatoses and the photodiagnostic techniques that can be applied. Management approaches include early diagnosis, prevention and disease suppression, and awareness of the significant adverse impact on well‐being and psychological health that can occur with photosensitivity. Photoprotection is a mainstay approach for the photodermatoses but is often not sufficient alone for disease control. Desensitisation through natural hardening or light‐based therapies may be feasible, although systemic immunosuppressants and immunomodulators may be required. Awareness of the possibility of vitamin D deficiency is also necessary. This chapter will cover these approaches in detail.

show abstract

Actinic prurigo in Scandinavian adolescent successfully treated with cyclosporine A

Cited by 4 publications

References 7 publications

A Review on Sun Exposure and Skin Diseases

A Review on Sun Exposure and Skin Diseases

Clearance of pediatric actinic prurigo with dupilumab

Cutaneous Photosensitivity Diseases

Contact Info

Product

Resources

About