Actinic prurigo

Ross, Gayle; Foley, Peter; Baker, Chris

doi:10.1111/j.1600-0781.2008.00375.x

Cited by 45 publications

(37 citation statements)

References 18 publications

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“…5 The use of thalidomide (50 to 100 mg/day) leads to the rapid lightening of skin lesions with a slower response of mucous lesions. 1,5,6 When treatment is suspended, symptoms return. Therefore, low maintenance doses are recommended with control of adverse reactions.…”

Section: Commentariesmentioning

confidence: 99%

“…Therefore, low maintenance doses are recommended with control of adverse reactions. 3,6 There is a report of control of the disease with the use of thalidomide for 23 years. 1 Abstract: A 13-year-old black boy had pruritic papular and nodular lesions on his forearms associated to edema of the lower lip, photophobia, conjunctivitis and pterygium.…”

Section: Commentariesmentioning

confidence: 99%

“…5 In temperate climates, it improves in the winter, whereas in tropical climates it stays the same throughout the year. 6 Skin lesions develop in photoexposed areas of the forearms, hands, neckline, face, ears, legs and feet.…”

Section: Commentariesmentioning

confidence: 99%

“…The last two appear to have a prophylactic effect. 1,5,6 Thalidomide reduces polymorphonuclear leukocyte phagocytosis, the production of tumoral necrosis factor-alpha (TNF-alpha), lymphocyte production, inhibits angiogenesis and converts the T-helper 1 cell response to T helper 2. 5 It is not clear how these effects modulate the activity of actinic prurigo.…”

Section: Commentariesmentioning

confidence: 99%

“…5 Eosinophils are also found. 6,7 Treatment of AP includes photoprotection, topical and systemic corticosteroids, antihistamines, antimalarial drugs, low doses of phototherapy (PUVA and UVB), and thalidomide. The last two appear to have a prophylactic effect.…”

Section: Commentariesmentioning

confidence: 99%

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Caso para diagnóstico

Daldon

Pascini

Correa³

2010

An. Bras. Dermatol.

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HISTORY OF THE DISEASEA thirteen-year-old black boy, native of Sao Paulo, complained of recurring pruritic lesions on his forearms associated with edema of the lower lip, photophobia, and red eyes that had developed two years before. Physical examination revealed conjunctival enanthema associated with pterygium ( Figure 1). The lower lip was everted, swollen, exulcerated with vegetant lesions all over its extension (Figure 2). Erythematous, scaly, crusted lesions in the nose ( Figure 1); excoriated papules and nodules in the forearms were observed in association with residual hyperchromic maculae ( Figure 3). The patient presented low cognitive development without previous diseases. He denied similar cases of the disease in his family. An Bras Dermatol. 2010;85(5):733-5.Skin biopsy of the lower lip showed acanthosis and spongiosis with dermal perivascular mononuclear cell infiltration composed by lymphocytes, plasma cells, and eosinophils (Figure 4). Eye examination revealed enanthema, Trantas dots, and pterygium. After three months of thalidomide use (100mg/day), remission of lesions was observed, including that of cheilitis. The patient suspended the medication and symptoms recrudesced. Treatment with thalidomide 100mg/day for six months was reestablished with rapid improvement; the dose was then reduced to 50mg/day and lesions were controlled for two more years. The patient's low cognitive development prevented the progressive reduction of medication.

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Section: Commentariesmentioning

confidence: 99%

Section: Commentariesmentioning

confidence: 99%

Section: Commentariesmentioning

confidence: 99%

Section: Commentariesmentioning

confidence: 99%

Section: Commentariesmentioning

confidence: 99%

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Caso para diagnóstico

Daldon

Pascini

Correa³

2010

An. Bras. Dermatol.

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Dermatoses of the Oral Cavity and Lips

Scully¹

2016

Rook's Textbook of Dermatology, Ninth Edition

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Oral and labial lesions are usually the result of local disease but may be the early signs of systemic disease, including dermatological disorders, and in some instances may cause the main symptoms. This chapter mainly discusses disorders of the periodontal and mucosal tissues that may be related to skin disease and that may present at a dermatology clinic. It should be borne in mind that the professionals most competent in diagnosing and treating oral diseases are those with formal dental training and who are therefore in a position to understand the full complexities of the region. This chapter is divided into a brief discussion of the biology of the mouth, an overview of the more common signs and symptoms affecting specific oral tissues, discussion of the disorders of the oral mucosa of most relevance to dermatology and a tabulated review of oral manifestations of systemic diseases. Only the more classic oral lesions are illustrated. For reasons of space restrictions, diseases affecting the teeth, salivary glands, jaws or temporomandibular joints are not discussed in any depth.

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