Actinic cheilitis: clinical and pathologic characteristics in 65 cases

Markopoulos, Anastasios K.; Albanidou-Farmaki, E.; Kayavis, I

doi:10.1016/s1079-2104(03)00385-8

Cited by 42 publications

(87 citation statements)

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“…13 Patients are usually males and have a mean age of 53 years. It presents as an atrophic white papule or plaque that usually becomes fissured, eroded, or ulcerated.…”

Section: Epidemiologymentioning

confidence: 99%

Squamous cell carcinoma of the skin: epidemiology, classification, management, and novel trends

2014

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Squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer. It originates from epidermal keratinocytes or adnexal structures (such as eccrine glands or pilosebaceous units). We describe the salient features of cutaneous SCC. We also review novel classification schemes proposed during the last decade which attempt to stratify SCC lesions based on prognosis. Biopsy leads to definitive diagnosis. Treatment includes surgical excision; Mohs micrographic surgery produces excellent cure rates and spares the maximal amount of tissue. Other modalities include electrodessication and curettage, cryosurgery, radiotherapy, topical medications, photodynamic therapy, and systemic therapy. Management and follow-up depend on the risk stratification of individual lesions.

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“…13 Patients are usually males and have a mean age of 53 years. It presents as an atrophic white papule or plaque that usually becomes fissured, eroded, or ulcerated.…”

Section: Epidemiologymentioning

confidence: 99%

Squamous cell carcinoma of the skin: epidemiology, classification, management, and novel trends

2014

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“…It is known that SCCs of the lip metastasize four times as frequently as cutaneous SCCs. 1,2 Hence, early and careful treatment of AC is mandatory. Therapeutic approaches include cryotherapy, electrosurgery, 5-fluorouracil, imiquimod, retinoids, carbon dioxide laser ablation and surgical excision.…”

mentioning

confidence: 99%

“…Patients were all male farmers, mean age 65AE4 years (range 60-71), with a mean disease duration of 3AE7 years (range [1][2][3][4][5][6][7][8]. Clinical changes at baseline included grey-white thickened, dry and fissured plaques, superficial erosions, crusting and constant scaling and permanent fissuring.…”

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confidence: 99%

Actinic cheilitis treated with one cycle of 5-aminolaevulinic acid-based photodynamic therapy: report of 10 cases

et al. 2008

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3 Braverman IM. The role of blood vessels and lymphatics in cutaneous inflammatory processes: an overview. Br J Dermatol 1983; 109 (Suppl. 25):89-98. 4 Cliff S, Bedlow AJ, Stanton AW, Mortimer PS. An in vivo study of the microlymphatics in psoriasis using fluorescence microlymphography. Br J Dermatol 1999; 140:61-6. 5 Ryan TJ. Microcirculation in psoriasis: blood vessels, lymphatics and tissue fluid. Pharmacol Ther 1980; 10:27-64. 6 Bacharach-Buhles M, El-Gammal S, Panz B, Altmeyer P. In psoriasis the epidermis, including the subepidermal vascular plexus, grows downwards into the dermis. Br J Dermatol 1997; 136:97-101. 7 Kahn HJ, Marks A. A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors. Lab Invest 2002; 82:1255-7.8 Kahn HJ, Bailey D, Marks A. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Mod Pathol 2002; 15:434-40. 9 Jackowski S, Janusch M, Fiedler E et al. Radiogenic lymphangiogenesis in the skin. Am J Pathol 2007; 171:338-48. 10 Staberg B, Klemp P, Aasted M et al. Lymphatic albumin clearance from psoriatic skin. J Am Acad Dermatol 1983; 9:857-61. 11 Davison SC, Ballsdon A, Allen MH, Barker JN. Early migration of cutaneous lymphocyte-associated antigen (CLA) positive T cells into evolving psoriatic plaques. Exp Dermatol 2001; 10:280-5. 12 Braun-Falco O, Christophers E. Structural aspects of initial psoriatic lesions. Arch Dermatol Forsch 1974; 251:95-110. 13 Braverman IM, Sibley J. Role of the microcirculation in the treatment and pathogenesis of psoriasis. J Invest Dermatol 1982; 78:12-17. 14 Staberg B, Worm AM, Klemp P, Rossing N. Transvascular transport and distribution of fluid and protein in psoriasis. J Am Acad Dermatol 1983; 8:193-9.

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“…[1][2][3][4][5][6] Once SCC of the lower lip has occurred, metastasis rates are high at 17% to 25%. Affecting an estimated 5% of the general population with a prevalence of 11.4% to 16.7% among farmers and fishermen, AC progresses to SCC at reported rates ranging from 1.4% to 36% over an interval of 1 to 30 years.…”

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confidence: 99%

“…Ablative therapies, such as cryotherapy and electrodessication, carry the disadvantages of hypopigmented scarring and long recovery times. 3,10,15,[18][19][20][21][22] Treatment of AC with topical 5% imiquimod 3 times per week for 5 to 6 weeks resulted in clearing at 4 weeks of follow-up; however, 60% of patients experienced a moderate-to-severe reaction of erythema, induration, erosions, or ulcerations. 10,17 Topical 5-fluorouracil and imiquimod are associated with severe and unpredictable side effects, including erythema, crusting, ulceration, scarring, and poor cosmetic outcomes.…”

mentioning

confidence: 99%

Commentary on Photodynamic Therapy of Actinic Cheilitis

Alexiades-Armenakas¹

2015

Dermatologic Surgery

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Actinic cheilitis: clinical and pathologic characteristics in 65 cases

Cited by 42 publications

References 0 publications

Squamous cell carcinoma of the skin: epidemiology, classification, management, and novel trends

Squamous cell carcinoma of the skin: epidemiology, classification, management, and novel trends

Actinic cheilitis treated with one cycle of 5-aminolaevulinic acid-based photodynamic therapy: report of 10 cases

Commentary on Photodynamic Therapy of Actinic Cheilitis

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