Actinic Cheilitis

Wright, Keith; Dufresne, Raymond G.

doi:10.1111/j.1524-4725.1998.tb04195.x

Cited by 7 publications

(7 citation statements)

References 4 publications

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“…Grade IIB studies of 5‐FU “pulse therapy” with application twice a day, but only once a week to minimize side effects have shown to be ineffective in clearing AC clinically and histologically 19 . Furthermore, as Robinson’s grade IB study indicates, even when 5‐FU treatment clears clinically visible AC lesions, histologic dysplasia often recurs within a few years 10,11 .…”

Section: Resultsmentioning

confidence: 99%

Actinic cheilitis: a treatment review

2010

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All other factors being equal, the presence of actinic cheilitis, a pre-invasive malignant lesion of the lips, doubles the risk of squamous cell carcinoma developing in this anatomic area. Various forms of local ablation,immunomodulation and surgical extirpation have been proposed as therapeutic interventions. This paper critically evaluates the available medical literature to highlight the evidence-based strength of each recommended therapy for actinic cheilitis. Vermilionectomy remains the gold standard for efficacy; trichloroacetic acid application is easy and convenient, but the least efficacious overall.

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Section: Resultsmentioning

confidence: 99%

Actinic cheilitis: a treatment review

2010

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“…The acute form is more common in young individuals and occurs after excessive exposure to the ultraviolet light, while the chronic form is a cumulative and irreversible alteration. In chronic AC, the lip appears parched and atrophic, with dyschromic areas, white or gray plaques and recurrent erosions 7 , 20 . The lesion is usually asymptomatic, but can in some cases be accompanied by a burning sensation, numbness and pain.…”

Section: Introductionmentioning

confidence: 99%

Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis

et al. 2010

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ObjectiveActinic cheilitis (AC) is a precancerous lesion of the lip vermillion caused by prolonged exposure to ultraviolet light. The aim of this study was to evaluate the effect of 3% diclofenac in 2.5% hyaluronic acid gel in the treatment of AC.MethodsThirty-four patients with chronic AC were treated twice a day with topical diclofenac during a period of 30 to 180 days. The individuals were followed up every 15 days by means of clinical examination and digital photographic documentation.ResultsOf the 27 patients that completed the study, 12 (44%) showed complete remission of the whitish plaques and exfoliative areas, and 15 (56%) had partial remission of the clinical picture of cheilitis. The latter group was submitted to excision of the leukoplakic areas which diagnosis varied from mild to moderate epithelial dysplasia.ConclusionThe results suggest a promising role for diclofenac in hyaluronic acid gel in the treatment of AC. This treatment has the advantages of not being invasive and showing few side effects.

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“…Dermabrasion has been described for the treatment of actinic damage, refractory actinic keratoses, and as a prophylactic treatment for the development of skin cancer, 21,22 but not on the vermilion surface. A range of treatments have been used to treat AC including cryotherapy, CO 2 laser, topical retinoids, 5‐fluorouracil, imiquimod electrodesiccation and curettage, photodynamic therapy, and vermilionectomy 4–19 …”

Section: Discussionmentioning

confidence: 99%

“…Actinic cheilitis (AC) is a common premalignant condition of the lips resulting from chronic or excessive ultraviolet exposure 1 . Many different treatment modalities have been reviewed in the literature 2,3,4 . Current methods include topical 5‐fluorouracil, 5 imiquimod, 6 photodynamic therapy, chemical peels, 7,8,9 cryosurgery, 10,11 electrodesiccation and curettage, 12 carbon dioxide laser, 13–17 and vermilionectomy with or without mucosal advancement 18 …”

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confidence: 99%