Actigraphy studies and clinical and biobehavioural correlates in schizophrenia: a systematic review

Wee, Zi Ying; Yong, Samantha Wei Lee; Chew, Qian Hui; Guan, Cuntai; Lee, Tih Shih; Sim, Kang

doi:10.1007/s00702-019-01993-2

Cited by 43 publications

(30 citation statements)

References 76 publications

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“…Additionally, disrupted 24-h activity rhythms have also been linked to more suicidal behaviors [63,64], but the causality of this association remains to be determined. Although actigraphy has been used in patients with schizophrenia, 24-h rhythmicity has not often been assessed [65]. Only one study assessed 24-h activity rhythms and did not find an association of 24-h rhythm estimates with positive or negative symptoms of schizophrenia [66].…”

Section: Other Psychiatric Disorders In Late Lifementioning

confidence: 99%

24-h Activity Rhythms and Health in Older Adults

Feijter

Lysen

Luik

2020

Curr Sleep Medicine Rep

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Purpose of Review Circadian rhythms, including 24-h activity rhythms, change with age. Disturbances in these 24-h activity rhythms at older age have also been implied in various diseases. This review evaluates recent findings on 24-h activity rhythms and disease in older adults. Recent Findings Growing evidence supports that 24-h activity rhythm disturbances at older age are related to the presence and/or progression of disease. Longitudinal and genetic work even suggests a potential causal contribution of disturbed 24-h activity rhythms to disease development. Interventional studies targeting circadian and 24-h activity rhythms demonstrate that 24-h rhythmicity can be improved, but the effect of improving 24-h rhythmicity on disease risk or progression remains to be shown. Summary Increasing evidence suggests that 24-h activity rhythms are involved in age-related diseases. Further studies are needed to assess causality, underlying mechanisms, and the effects of treating disturbed 24-h activity rhythms on age-related disease.

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Section: Other Psychiatric Disorders In Late Lifementioning

confidence: 99%

24-h Activity Rhythms and Health in Older Adults

Feijter

Lysen

Luik

2020

Curr Sleep Medicine Rep

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“…In patients with multiple episodes, motor activity was higher during the first episode [89]. The promotion of physical exercise in this patient group may be supported using objective data, generating a dynamic feedback for patients [90].…”

Section: Actigraphy In Psychiatry Supports Principles Of 3p Medicinementioning

confidence: 80%

Wrist actigraphic approach in primary, secondary and tertiary care based on the principles of predictive, preventive and personalised (3P) medicine

et al. 2021

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Sleep quality and duration as well as activity-rest-cycles at individual level are crucial for maintaining physical and mental health. Although several methods do exist to monitor these parameters, optimal approaches are still under consideration and technological development. Wrist actigraphy is a non-invasive electro-physical method validated in the field of chronobiology to record movements and to allow for monitoring human activity-rest-cycles. Based on the continuous recording of motor activity and light exposure, actigraphy provides valuable information about the quality and quantity of the sleep–wake rhythm and about the amount of motor activity at day and night that is highly relevant for predicting a potential disease and its targeted prevention as well as personalisation of medical services provided to individuals in suboptimal health conditions and patients. Being generally used in the field of sleep medicine, actigraphy demonstrates a great potential to be successfully implemented in primary, secondary and tertiary care, psychiatry, oncology, and intensive care, military and sports medicines as well as epidemiological monitoring of behavioural habits as well as well-being medical support, amongst others. Prediction of disease development and individual outcomes Activity-rest-cycles have been demonstrated to be an important predictor for many diseases including but not restricted to the development of metabolic, psychiatric and malignant pathologies. Moreover, activity-rest-cycles directly impact individual outcomes in corresponding patient cohorts. Targeted prevention Data acquired by actigraphy are instrumental for the evidence-based targeted prevention by analysing individualised patient profiles including light exposure, sleep duration and quality, activity-rest-cycles, intensity and structure of motion pattern. Personalised therapy Wrist actigraphic approach is increasingly used in clinical care. Personalised measurements of sedation/agitation rhythms are useful for ICU patients, for evaluation of motor fatigue in oncologic patients, for an individual enhancement of performance in military and sport medicine. In the framework of personalised therapy intervention, patients can be encouraged to optimise their behavioural habits improving recovery and activity patterns. This opens excellent perspectives for the sleep-inducing medication and stimulants replacement as well as for increasing the role of participatory medicine by visualising and encouraging optimal behavioural patterns of the individual.

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“…In general, reduced activity has been found to correlate with higher negative symptoms, in particular apathy, but not expressive deficits. Although a few studies that obtained symptom assessment and actigraphy measures did not report any correlation, indicating that such correlations were not always found (9)(10)(11)(12). However, to our knowledge, all studies used activity counts as the primary variable assessing activity levels.…”

Section: Introductionmentioning

confidence: 92%

Deep Learning-Based Human Activity Recognition for Continuous Activity and Gesture Monitoring for Schizophrenia Patients With Negative Symptoms

et al. 2020

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Background: We aimed to develop a Human Activity Recognition (HAR) model using a wrist-worn device to assess patient activity in relation to negative symptoms of schizophrenia. Methods: Data were analyzed in a randomized, three-way cross-over, proof-of-mechanism study (ClinicalTrials.gov: NCT02824055) comparing two doses of RG7203 with placebo, given as adjunct to stable antipsychotic treatment in patients with chronic schizophrenia and moderate levels of negative symptoms. Baseline negative symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS) and Brief Negative Symptom Scale (BNSS). Patients were given a GeneActiv ™ wrist-worn actigraphy device to wear over a 15week period. For this analysis, actigraphy data and behavioral and clinical assessments obtained during placebo treatment were used. Motivated behavior was evaluated with a computerized effort-choice task. A trained HAR model was used to classify activity and an activity-time ratio was derived. Gesture events and features were inferred from the HARdetected activities and the acceleration signal.

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Actigraphy studies and clinical and biobehavioural correlates in schizophrenia: a systematic review

Cited by 43 publications

References 76 publications

24-h Activity Rhythms and Health in Older Adults

24-h Activity Rhythms and Health in Older Adults

Wrist actigraphic approach in primary, secondary and tertiary care based on the principles of predictive, preventive and personalised (3P) medicine

Deep Learning-Based Human Activity Recognition for Continuous Activity and Gesture Monitoring for Schizophrenia Patients With Negative Symptoms

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