ACTH and the corticosteroids in themanagement of allergic disorders in children

Siegel, Sheldon C.

doi:10.1016/s0022-3476(65)80069-5

Cited by 15 publications

(2 citation statements)

References 256 publications

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“…"-1 \, 20 Prednisone is probably the most used oral corticoid derivative; it is agreed that conversion to prednisolone represents a step necessary to achieve biologic potency. 8,14,18 Individual variations in intestinal adsorption, conversion, steroid compartimentation, and metabolism are admittedly factors which may subserve profound differences in the response to administered prednisone among patients otherwise homogeneously grouped.…”

Section: Discussionmentioning

confidence: 99%

Diurnal variation of prednisolone binding to serum corticosteroid‐binding globulin in man

Angeli

Frajria

Paoli

et al. 1978

Clin Pharma and Therapeutics

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Serum corticosteroid-binding globulin (CBG, transcortin) binding capacity for prednisolone and for cortisol, and levels of the circulating cortisol were evaluated in healthy adult subjects and in patients under long-term treatment with prednisone. Blood samples were drawn at 4-hr intervals throughout at least 24 hr; the prednisone administration was discontinued 24 hr before starting examination. Circadian fluctuations in the CBG-binding capacity for prednisolone occurred in healthy subjects: maximum binding was at 12 midnight and minimum binding at 8 a.m. The diurnal pattern of prednisolone-binding capacity was characterized by phase shifts of approximately 12 hr and 8 hr compared with those of serum cortisol and cortisol-binding capacity, respectively. There were no diurnal variations of prednisolone- and cortisol-binding capacity in the prednisone-treated patients. Moreover, the levels of both capacities, expressed as micrograms bound steroid/100 ml, were significantly reduced with respect to normal control subjects. Cyclic variations in serum CBG-binding capacity may represent an additional factor accounting for temporal differences in the action of synthetic corticoids which are bound by the transport protein. Synthetic derivatives when chronically administered may interfere not only with the adrenal secretion but also with the serum transport of glucocorticoids.

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Section: Discussionmentioning

confidence: 99%

Diurnal variation of prednisolone binding to serum corticosteroid‐binding globulin in man

Angeli

Frajria

Paoli

et al. 1978

Clin Pharma and Therapeutics

View full text Add to dashboard Cite

show abstract

“…The side effects and dangers of corticosteroid therapy are familiar and have been outlined elsewhere (5,6). One of the principle dangers is that these dramatically effective agents may come to be relied on as a substitute for an adequately thoughtful and searching program of conventional management of childhood allergies.…”

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confidence: 99%