Treatment of the Nephrotic Syndrome in Childhood

Treatment of childhood asthma for 13 months and longer with beclomethasone dipropionate aerosol

“…It has been shown that continuous treatment with oral steroids causes serious growth stunting (Falliers et al, 1963), while the use of an alternate-day regimen (Zachmann, 1970;Soyka, 1967), or possibly of corticotrophin (Friedman and Strang, 1966), diminished this complication. However, severe asthma in itself tends to stunt growth (Falliers et al, 1963) even without steroid therapy, and it might therefore have been expected that beclomethasone would actually result in a growth spurt if it was truly free from systemic activity.…”

Effect of Alternate-Day Hydrocortisone Therapy on the Immunologically Immature Rat. I: Effect on Blood Cell Count, Immunoglobulin Concentrations, and Body and Organ Weights

“…In most cases, the therapeutic effectiveness of the alternate-day therapy program was nearly similar to that with conventional dosage schedules (33,34). The ability of an alternate-day corticosteroid regimen to minimize or prevent manifestation of Cushing's syndrome tradi: tionally associated with long-term steroid therapy has become a familiar clinical observation (32-34).…”

Effect of alternate-day, single-dose, corticosteroid therapy on pituitary-adrenal function.

“…It is open to speculation whether this regime is associated with other advantages, or whether it may incur some disadvantages. Ackerman and Nolan (1968), Soyka and Saxena (1965), and Soyka (1967) have indicated that, when much larger doses of steroids are administered in this way to patients with other diseases such as the nephrotic syndrome, there is a diminution of certain other side-effects-notably the Cushingoid appearance and the inhibition of growth in juveniles.…”