Acrylonitrile Adducts: An Efficient Adsorbent Media for Removal of Iron from Water

Das, Parineeta; Dutta, Dhiraj; Sarkar, Ankita; Dubey, Rama; Пузари, Амрит

doi:10.1002/slct.202203048

Cited by 2 publications

(2 citation statements)

References 63 publications

(134 reference statements)

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“…These adducts have multiple applications. It has been reported that the adducts showed prominent adsorption of Fe 2+ ion from aqueous media 36 . In addition to it, this work aims to investigate the activity of acrylonitrile adducts against antimicrobial and biological properties.…”

Section: Introductionmentioning

confidence: 95%

Acrylonitrile adducts: design, synthesis and biological evaluation as antimicrobial, haemolytic and thrombolytic agent

Das

Devi

Gaur

et al. 2023

Sci Rep

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In this work, five acrylonitrile adducts were screened for antibacterial activity against Gram-positive Bacillus subtilis, Microbial Type Culture Collection and Gene Bank (MTCC 1305) and Gram-negative Escherichia coli (MTCC 443). Synthesis was followed by aza-Michael addition reaction, where the acrylonitrile accepts an electron pair from the respective amines and results in the formation of n-alkyliminobis-propionitrile and n-alkyliminopropionitrile under microwave irradiation. Characterization of the compounds were performed using Fourier Transform Infrared (FTIR), Proton Nuclear Magnetic Resonance (1H NMR) and Electrospray Ionisation Mass Spectrometry (ESI–MS). The particle size characterization was done by Dynamic Light Scattering (DLS) technique. The antibacterial study showed higher inhibition rate for both Gram-positive and Gram-negative bacteria. The antibacterial ability was found to be dose dependent. The minimum inhibitory concentration against both bacteria were found to be 1, 3, 0.4, 1, 3 µl/ml for E. coli and 6, 6, 0.9, 0.5, 5 µl/ml for B. subtilis. Time-kill kinetics evaluation showed that the adducts possess bacteriostatic action. Further it was evaluated for high-throughput in vitro assays to determine the compatibility of the adducts for drug delivery. The haemolytic and thrombolytic activity was analysed against normal mouse erythrocytes. The haemolytic activity showed prominent results, and thereby projecting this acrylonitrile adducts as potent antimicrobial and haemolytic agent.

show abstract

Section: Introductionmentioning

confidence: 95%

Acrylonitrile adducts: design, synthesis and biological evaluation as antimicrobial, haemolytic and thrombolytic agent

Das

Devi

Gaur

et al. 2023

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…These adducts have multiple applications. It has been reported that the adducts showed prominent adsorption of Fe 2+ ion from aqueous media 24 . In addition to it, this work aims to investigate the activity of acrylonitrile adducts against antimicrobial properties.…”

Section: Introductionmentioning

confidence: 95%

High antimicrobial effectiveness of acrylonitrile adducts and evaluation of their biological activity as haemolytic and thrombolytic agent

Das

Devi

Gaur

et al. 2023

Preprint

View full text Add to dashboard Cite

In this work, five acrylonitrile adducts were screened for antibacterial activity against Gram-positive Bacillus subtilis (MTCC 1305) and Gram-negative Escherichia coli (MTCC 443). Synthesis was followed by aza-Michael addition reaction, where the acrylonitrile accepts an electron pair from the respective amines and results in the formation of n-alkyliminobis-propionitrile and n-alkyliminopropionitrile under microwave irradiation. Characterization of the compounds were performed using FTIR, 1H NMR and ESI-MS. The particle size characterization was done by DLS technique. The antibacterial study showed higher inhibition rate for both Gram-positive and Gram-negative bacteria. The antibacterial ability was found to be dose dependent. The minimum inhibitory concentration against both bacteria were found to be 1, 3, 0.4, 1, 3 µl/ml for E. coli and 6, 6, 0.9, 0.5, 5 µl/ml for B. subtilis. Time-kill kinetics evaluation showed that the adducts possess bacteriostatic action. Further it was evaluated for high-throughput in vitro assays to determine the compatibility of the adducts for drug delivery. The haemolytic and thrombolytic activity was analysed against normal mouse erythrocytes. The haemolytic activity showed prominent results, and thereby projecting this acrylonitrile adducts as potent antimicrobial and haemolytic agent.

show abstract

Acrylonitrile Adducts: An Efficient Adsorbent Media for Removal of Iron from Water

Cited by 2 publications

References 63 publications

Acrylonitrile adducts: design, synthesis and biological evaluation as antimicrobial, haemolytic and thrombolytic agent

Acrylonitrile adducts: design, synthesis and biological evaluation as antimicrobial, haemolytic and thrombolytic agent

High antimicrobial effectiveness of acrylonitrile adducts and evaluation of their biological activity as haemolytic and thrombolytic agent

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