Acrylic hydrogels‐based biocomposites: Synthesis and characterization

Sandu, Teodor; Sârbu, Andrei; Constantin, Floriana; Vulpe, Silviu; Iovu, Horia

doi:10.1002/app.37992

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…MA was chosen based on its controllable reactivity and importance as a monomer widely used for the preparation of hydrogels. MA‐based hydrogels find numerous applications in various fields, from therapeutics to environmental applications . The proposed mechanism for the copolymerization of MA in the presence of AcGGM and PAA oligomers is shown in Scheme .…”

Section: Resultsmentioning

confidence: 99%

Design of renewable poly(amidoamine)/hemicellulose hydrogels for heavy metal adsorption

Ferrari

Ranucci

Edlund

et al. 2014

J of Applied Polymer Sci

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Renewable poly(amidoamine)/hemicellulose hydrogels were prepared from O-acetylated galactoglucomannan (AcGGM)rich biomass and shown to display a significantly high adsorption capacity for Cu 21 , Cd 21 , Pb 21, Zn 21 , Ni 21 , Co 21 , and CrO 2-4 . Two different acrylamido end-capped poly(amidoamine) oligomers (PAA) were prepared and covalently immobilized onto an in situ formed polysaccharide network via water-based free radical graft copolymerization and cross-linking. The synthetic approach was shown to be viable when using a highly purified AcGGM or a crude spruce hydrolysate, an AcGGM and lignin containing biomass fraction as a reactant. Homogeneous reaction mixtures were obtained in both cases with polysaccharide contents up to 20% by weight. Oscillatory shear measurements indicated a predominantly solid-like behavior of the hydrogels with an increase in shear storage modulus with increasing cross-link density. The mechanical integrity of the PAA/hemicellulose hydrogels showed higher water swelling capacity and less fragility than the parent PAA hydrogels and they retained the heavy metal ion absorption ability of the PAA component, even in the presence of the least purified hemicellulose fraction.

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Section: Resultsmentioning

confidence: 99%

Design of renewable poly(amidoamine)/hemicellulose hydrogels for heavy metal adsorption

Ferrari

Ranucci

Edlund

et al. 2014

J of Applied Polymer Sci

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“…Hydrogels based on acrylic acid are widely considered for application e.g. in controlled drug delivery systems [11], as wound dressings [12], in tissue engineering [13] or as biosensors [14]. For example, Mohamad et al described hydrogels based on acrylic acid and bacterial cellulose obtained via electron beam irradiation.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Investigations of Hydrogels Containing Gold Nanoparticles Designed for Biomedical Use

Głąb

Kudłacik–Kramarczyk

Drabczyk

et al. 2021

JCME

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Currently, many investigations are being performed to develop dressing materials with a positive effect on the wound healingprocess. In general, innovative dressings should ensure wound exudate absorption, constitute an external barrier limiting thepossibility of wound contamination and, importantly, also provide therapeutic properties. This work is focused on obtainingmaterials with potential use as dressings for treatment of difficult-to-heal wounds. The synthesis methodology of acrylic hydrogelsmodified with selected modifiers, i.e. arabic gum, nanogold, bee pollen and chamomile extract, was developed. Next, thesorption properties of the materials were determined as well as their behavior during the incubation in fluids imitating theenvironment of the human body. Additionally, the impact of such an incubation on their structure was evaluated by FT-IR spectroscopy.It was proved that the modifiers affected the sorption properties of hydrogels, i.e. samples with additives showed evenapprox. 2.5-fold lower swelling ability. In turn, incubation of hydrogels in simulated body fluids did not cause any rapid changesin pH, which may indicate the biocompatibility of the tested materials with the tested fluids. Thus, it may be concluded that thedeveloped materials show great application potential for biomedical purposes and may be subjected to more advanced studiessuch as cytotoxicity assessments towards selected cell lines.

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“…[21][22][23][24] Whilst excellent mechanical properties have been reported for such gels, 25 one common limitation in the context of biomaterials applications is that gel construction methods rely on the use of small molecule monomers. 14,[17][18][19][20][25][26][27][28][29][30][31][32] In this study we introduce a new generic approach that enables the rational design of highly deformable pH-responsive hydrogels using aqueous dispersions of pre-formed polyacid NPs as the only gel building blocks.…”

Section: Introductionmentioning

confidence: 99%

Highly deformable hydrogels constructed by pH-triggered polyacid nanoparticle disassembly in aqueous dispersions

Wang

Zhu

et al. 2018

Soft Matter

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Most hydrogels are prepared using small-molecule monomers but unfortunately this approach may not be feasible for certain biomaterial applications. Consequently, alternative gel construction strategies have been established, which include using covalent inter-linking of preformed gel particles, or microgels (MGs). For example, covalently interlinking pH-responsive MGs can produce hydrogels comprising doubly crosslinked microgels (DX MGs). We hypothesised that the deformability of such DX MGs was limited by the presence of intra-MG crosslinking. Thus, in this study we designed new nanoparticle (NP)-based gels based on pH-swellable NPs that are not internally crosslinked. Two polyacid NPs were synthesised containing methacrylic acid (MAA) and either ethyl acrylate (EA) or methyl methacrylate (MMA). The PMAA-EA and PMAA-MMA NPs were subsequently vinyl-functionalised using glycidyl methacrylate (GMA) prior to gel formation via free-radical crosslinking. The NPs mostly disassembled on raising the solution pH but some self-crosslinking was nevertheless evident. The gels constructed from the EA- and MMA-based NPs had greater breaking strains than a control DX MG. The effect of varying the solution pH during curing on the morphology and mechanical properties of gels prepared using PMAA-MMA-GMA NPs was studied and both remarkable deformability and excellent recovery were observed. The gels were strongly pH-responsive and had tensile breaking strains of up to 420% with a compressive strain-at-break of more than 93%. An optimised formulation produced the most deformable and stretchable gel yet constructed using NPs or MGs as the only building block.

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Acrylic hydrogels‐based biocomposites: Synthesis and characterization

Cited by 7 publications

References 28 publications

Design of renewable poly(amidoamine)/hemicellulose hydrogels for heavy metal adsorption

Design of renewable poly(amidoamine)/hemicellulose hydrogels for heavy metal adsorption

Physicochemical Investigations of Hydrogels Containing Gold Nanoparticles Designed for Biomedical Use

Highly deformable hydrogels constructed by pH-triggered polyacid nanoparticle disassembly in aqueous dispersions

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