Acrylamide Polymer Double-Network Hydrogels

Arnold, Markus; Daniels, A. U.; Ronken, Sarah; Garcia, H. Ardura; Friederich, Niklaus F.; Kurokawa, Takayuki; Gong, Jian Ping; Wirz, Dieter

doi:10.1177/1947603511402320

Cited by 28 publications

(11 citation statements)

References 22 publications

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“…Typically, the first network provides a rigid structure and the second network is ductile, resulting in greater toughness than the corresponding single networks alone would have achieved since the network can yield under mechanical load (Gong, 2010). These types of networks have gained interest in cartilage tissue engineering due to their superior mechanical properties over traditional hydrogels, including those that can approach the mechanics of native hyaline cartilage (Arnold et al ., 2011). Double networks are also conceptually appealing since cartilage and other skeletal tissues inherently incorporate double networks into their ECM in order to achieve their robust mechanical properties (Arnold et al ., 2011).…”

Section: A Improvements In Hydrogel Structurementioning

confidence: 99%

“…These types of networks have gained interest in cartilage tissue engineering due to their superior mechanical properties over traditional hydrogels, including those that can approach the mechanics of native hyaline cartilage (Arnold et al ., 2011). Double networks are also conceptually appealing since cartilage and other skeletal tissues inherently incorporate double networks into their ECM in order to achieve their robust mechanical properties (Arnold et al ., 2011). …”

Section: A Improvements In Hydrogel Structurementioning

confidence: 99%

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Recent advances in hydrogels for cartilage tissue engineering

Vega¹,

Kwon²,

Burdick

2017

eCM

251

176

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Articular cartilage is a load-bearing tissue that lines the surface of bones in diarthrodial joints. Unfortunately, this avascular tissue has a limited capacity for intrinsic repair. Treatment options for articular cartilage defects include microfracture and arthroplasty; however, these strategies fail to generate tissue that adequately restores damaged cartilage. Limitations of current treatments for cartilage defects have prompted the field of cartilage tissue engineering, which seeks to integrate engineering and biological principles to promote the growth of new cartilage to replace damaged tissue. To-date, a wide range of scaffolds and cell sources have emerged towards cartilage tissue engineering, with a focus on recapitulating microenvironments present during development or in adult tissue to induce the formation of cartilaginous constructs with biochemical and mechanical properties of native tissue. Hydrogels have emerged as a promising scaffold due to the wide range of properties that are possible and the ability to entrap cells within the material. Towards improving cartilage repair, hydrogel design has advanced in recent years to improve their utility. Some of these advances include the development of improved network crosslinking (e.g., double-networks), new techniques to process hydrogels (e.g., 3D printing), and the better incorporation of biological signals (e.g., controlled release). This review summarizes these innovative approaches to engineer hydrogels towards cartilage repair, with an eye towards eventual clinical translation.

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Section: A Improvements In Hydrogel Structurementioning

confidence: 99%

Section: A Improvements In Hydrogel Structurementioning

confidence: 99%

Recent advances in hydrogels for cartilage tissue engineering

Vega¹,

Kwon²,

Burdick

2017

eCM

251

176

View full text Add to dashboard Cite

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“…The different fixing methods for hydrogels to aluminium were compared by Arnold et al who tore PAMPS/PDMAAm and PAMPS/PAAm DN hydrogels, fixed with either an acrylic adhesive or surgical sutures (Vicryl 4/0) [ 160 ]. The sutured PAMPS/PDMAAm had an excellent tear out strength, with a maintained pull out strength value similar to nasal cartilage.…”

Section: Hydrogel Integrationmentioning

confidence: 99%

Hydrogels as a Replacement Material for Damaged Articular Hyaline Cartilage

et al. 2016

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Hyaline cartilage is a strong durable material that lubricates joint movement. Due to its avascular structure, cartilage has a poor self-healing ability, thus, a challenge in joint recovery. When severely damaged, cartilage may need to be replaced. However, currently we are unable to replicate the hyaline cartilage, and as such, alternative materials with considerably different properties are used. This results in undesirable side effects, including inadequate lubrication, wear debris, wear of the opposing articular cartilage, and weakening of the surrounding tissue. With the number of surgeries for cartilage repair increasing, a need for materials that can better mimic cartilage, and support the surrounding material in its typical function, is becoming evident. Here, we present a brief overview of the structure and properties of the hyaline cartilage and the current methods for cartilage repair. We then highlight some of the alternative materials under development as potential methods of repair; this is followed by an overview of the development of tough hydrogels. In particular, double network (DN) hydrogels are a promising replacement material, with continually improving physical properties. These hydrogels are coming closer to replicating the strength and toughness of the hyaline cartilage, while offering excellent lubrication. We conclude by highlighting several different methods of integrating replacement materials with the native joint to ensure stability and optimal behaviour.

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“…investigated the effect of pH and temperature on hydrogen bonding between poly(acrylic acid) and hydrogen‐acceptor poly( N , N ‐dimethylacrylamide) (PDMA) by cloud point measurement of dilute solution by using lower critical solution temperature behavior of interpolymer complex of these polymers. Arnold et al . demonstrated the use of poly(2‐acrylamido‐2‐methylpropanesulfonic acid)/PDMA (PAMPS/PDMA) double‐network in the repair of skeletal system soft tissues and the physicochemical stability and tissue compatibility to foster cartilage formation.…”

Section: Introductionmentioning

confidence: 99%

Low corrosion optically clear adhesives for conducting glass: I. Effects of N,N‐diethylacrylamide and acrylic acid mixtures on optically clear adhesives

Kuo

Chen

Chang

2018

J of Applied Polymer Sci

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This study designs less corrosive optically clear adhesives (OCAs) with good rework properties, where copolymer and glycidyl methacrylate (GMA) are cured by ultraviolet to form OCAs. The copolymer are synthesized by using N,N-diethylacrylamide (DMA), acrylic acid (AA), and 2-ethylhexyl acrylate. The DMA and AA could form acid-base interaction and therefore lower the corrosion on metallic substrate caused by AA. Copolymer is applied in OCAs, as different adhesive properties are presented. In terms of the adhesive property of OCAs, the peel strength, shear strength, and transmittance property are decreased when the GMA concentration is increased. The tack and haze are enhanced accordingly. After 7 days' standing at 60 8C and 90% RH, OCAs have no obvious corrosion on the conductive glass circuits, and there is no residue after peeling off.

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Acrylamide Polymer Double-Network Hydrogels

Cited by 28 publications

References 22 publications

Recent advances in hydrogels for cartilage tissue engineering

Recent advances in hydrogels for cartilage tissue engineering

Hydrogels as a Replacement Material for Damaged Articular Hyaline Cartilage

Low corrosion optically clear adhesives for conducting glass: I. Effects of N,N‐diethylacrylamide and acrylic acid mixtures on optically clear adhesives

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