Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-κB pathways regulated by MAPKs

Pan, Xiaoqi; Wu, Xu; Yan, Dandan; Peng, Cheng; Rao, Chaolong; Hong, Yan

doi:10.1016/j.toxlet.2018.02.002

Cited by 111 publications

(61 citation statements)

References 42 publications

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“…In turn, increased ROS can lead to the oxidation of membrane lipids. Similar findings have been reported showing elevated serum malondialdehyde levels in rats after acrylamide treatment [36,37].…”

Section: Discussionsupporting

confidence: 90%

Acrylamide reduces plasma antioxidant vitamin levels in rats due to increased oxidative damage

Yener

Yerlikaya

2020

Rev. Nutr.

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Objective Acrylamide is a potentially neurotoxic and carcinogenic chemical and naturally creates during the heating process of carbohydrate-rich foods, such as potato chips and breakfast cereals. Acrylamide might be ingested by people via consuming food that contains it. Therefore, we investigated the effect of acrylamidegiven orally to male and female rats on plasma retinoic acid and α-tocopherol and serum sialic acid and malondialdehyde levels. Method A total of 50 Wistar rats were used (25 female and 25 male, three-four weeks old). The rats of each sex were given 2 and 5mg/kg/day acrylamide via drinking water for 90 days. At the end of the treatment, the animals were euthanized by cervical dislocation. Blood specimens were collected through cardiac puncture, and serum and plasma samples were analysed using the high-performance liquid chromatography technique with a Ultraviolet detector. Results The analysis of the plasma and serum samples revealed that serum sialic acid and malondialdehyde levels in both sexes given 5mg/kg/day acrylamide were significantly increased, and the serum sialic acid levels were higher in female rats given 2mg/kg/day acrylamide. The plasma retinoic acid and α-tocopherol levels significantly decreased in both sexes given only the highest dose. Conclusion The results show that acrylamide causes an increase in oxidative stress and leads to a decrease in the levels of retinoic acid and α-tocopherol which play a role in the defense mechanism against this stress.

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Section: Discussionsupporting

confidence: 90%

Acrylamide reduces plasma antioxidant vitamin levels in rats due to increased oxidative damage

Yener

Yerlikaya

2020

Rev. Nutr.

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“…Inflammatory factors such as TNF-α can promote the expression of inflammatory genes through mitogen activated protein kinases (MAPKs) cascade and NF-κB activation [95,96]. Therefore, inhibiting MAPKs and/or NF-κB pathway may significantly reduce the expression of inflammatory genes [97]. Aulakh et al [72] found that the inhibition of FAK expression may effectively inhibit vascular cell adhesion factor-1 (VCAM-1) expression.…”

Section: The Function Of Fak In Regulating Inflammation Pathwaymentioning

confidence: 99%

The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review

Zhou

Qian

Tang

2019

J Exp Clin Cancer Res

230

160

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FAK is a tyrosine kinase overexpressed in cancer cells and plays an important role in the progression of tumors to a malignant phenotype. Except for its typical role as a cytoplasmic kinase downstream of integrin and growth factor receptor signaling, related studies have shown new aspects of the roles of FAK in the nucleus. FAK can promote p53 degradation through ubiquitination, leading to cancer cell growth and proliferation. FAK can also regulate GATA4 and IL-33 expression, resulting in reduced inflammatory responses and immune escape. These findings establish a new model of FAK from the cytoplasm to the nucleus. Activated FAK binds to transcription factors and regulates gene expression. Inactive FAK synergizes with different E3 ligases to promote the turnover of transcription factors by enhancing ubiquitination. In the tumor microenvironment, nuclear FAK can regulate the formation of new blood vessels, affecting the tumor blood supply. This article reviews the roles of nuclear FAK in regulating gene expression. In addition, the use of FAK inhibitors to target nuclear FAK functions will also be emphasized.

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“…In particular, AA has been demonstrated to be neurotoxic in humans and laboratory animals [ 20 , 21 , 22 ], resulting in sensory and motor dysfunction, skeletal muscle weakness, weight loss, and ataxia [ 23 ]. One of the important mechanisms by which AA induces neurotoxicity is that it can destroy the redox balance and induce oxidative stress in neurons [ 24 , 25 ]. Under oxidative stress of AA, intracellular ROS were greatly produced, GSH levels decreased rapidly, and a series of oxidative stress followed [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Preventive Effects of Three Polysaccharides on the Oxidative Stress Induced by Acrylamide in a Saccharomyces cerevisiae Model

Lin

Zhang

et al. 2020

Marine Drugs

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Saccharomyces cerevisiae was used as a model to explore the preventive effect of two marine polysaccharides separately derived from Sepia esculenta ink (SIP) and Laminaria japonica (FL) as well as one terrestrial polysaccharides from Eleocharis tuberosa peel (WCPP) on toxic injury induced by acrylamide (AA). The growth of yeast was evaluated by kinetics indexes including doubling time, lag phase and maximum proliferation density. Meanwhile, intracellular redox state was determined by contents of MDA and GSH, and SOD activity. The results showed that AA inhibited yeast growth and destroyed the antioxidant defense system. Supplement with polysaccharides, the oxidative damage of cells was alleviated. According to the growth recovery of yeast, FL and WCPP had similar degree of capacity against AA associated cytotoxicity, while SIP was 1.5~2 folds as strong as FL and WCPP. SIP and FL significantly reduced production of MDA by AA administration. Moreover, SIP, FL and WCPP increased SOD activity and repressed GSH depletion caused by AA.

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Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-κB pathways regulated by MAPKs

Cited by 111 publications

References 42 publications

Acrylamide reduces plasma antioxidant vitamin levels in rats due to increased oxidative damage

Acrylamide reduces plasma antioxidant vitamin levels in rats due to increased oxidative damage

The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review

Preventive Effects of Three Polysaccharides on the Oxidative Stress Induced by Acrylamide in a Saccharomyces cerevisiae Model

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