Acrokeratoelastoidosis

Abstract

A case of acrokeratoelastoidosis (AKE) is reported. A review of the literature has established that at least three clinicopathological entities have been reported under this term. Two of the entities show a combination of hyperkeratosis with fragmentation of dermal elastic tissue, which justifies the designation AKE. The first, for which the term familial AKE is perhaps appropriate, though many cases have been sporadic, begins in childhood or early adult life, and there is no evidence that trauma or light exposure are factors in its production. The second is a more variable clinical syndrome occurring in middle or late adult life, and both physical trauma and light exposure appear to be concerned in its induction. The third syndrome to be reported under the designation AKE shows no abnormality of elastic tissue and appears to be a separate entity.

Familial Focal Acral Hyperkeratosis Associated with Hyperthyroidism

“…Her oldest sister and her daughter exhibited iants have been documented. 3 Lesions gradually increase in number and size over the years like our case.…”

“…There is no evidence that trauma, arsenic ingestion, or light exposure are factors in the development of these disorders. 3 To our knowledge, there were no reports on an association between FAH and hyperthyroidism. However, rapid extension of AKE lesions during pregnancy has been reported.…”

“…These findings suggest that thyroid hormone might have a suppressive effect on AKE and FAH. However, two previous reports 3,6 did not clearly describe AKE deterio-…”

“…However, rapid extension of AKE lesions during pregnancy has been reported. 3,6 In one report, AKE lesions first appeared at the age of 6 years showed rapid extension during her pregnancy at the age of 20 years old. Abnormal thyroid function during pregnancy is well known.…”

“…[2][3][4][5][6] No human papilloma virus (HPV) DNA has been detected in affected lesions. There is no evidence that trauma, arsenic ingestion, or light exposure are factors in the development of these disorders.…”