Acrodermatitis Enteropathica Successfully Treated with Diodoquin1

Bloom, David C.; Sobel, Nathan

doi:10.1038/jid.1955.29

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Mutations Of Zinc Metabolism1

Clinical and Histopathological Findings As Reported In Liter1

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2008

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Cited by 27 publications

(2 citation statements)

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“…Other groups confirmed the therapeutic effect of diiodoquinoline as well. 38,39 However, enthusiasm for the use of this antimalarial was tempered by the subsequent recognition that irreversible retinopathy was a predictable complication of diiodoquinoline therapy. The link between zinc deficiency and AE was formally hypothesized by and zinc supplementation quickly became the therapy of choice for AE.…”

Section: Mutations Of Zinc Metabolismmentioning

confidence: 98%

Acrodermatitis enteropathica and an overview of zinc metabolism

Maverakis¹,

Fung

Lynch³

et al. 2007

Journal of the American Academy of Dermatology

326

325

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Section: Mutations Of Zinc Metabolismmentioning

confidence: 98%

Acrodermatitis enteropathica and an overview of zinc metabolism

Maverakis¹,

Fung

Lynch³

et al. 2007

Journal of the American Academy of Dermatology

326

325

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“…A summary of the literature on AE is given in Table 1, including type of lesions, age at onset or presentation, presence of infection, whether the AE was considered innate or acquired, whether vesicles or bullae were described and, when reported, any histopathological findings 5–8,10–13,15–38 …”

Section: Clinical and Histopathological Findings As Reported In Litermentioning

confidence: 99%

Bullous lesions in acrodermatitis enteropathica delaying diagnosis of zinc deficiency: a report of two cases and review of the literature

et al. 2008

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Acrodermatitis enteropathica (AE) is a rare disorder associated with poor absorption of zinc. A variety of clinical and histological findings have been reported in the literature, described mainly in isolated case reports. Because of the varied nature of these cases, the histological features of AE are described often as non-specific. We describe lesions of AE in two patients who presented with vesiculobullous and erosive skin lesions, both showing intra-epidermal, inflammatory vesiculation with surrounding eosinophilic epidermis and necrotic keratinocytes. The lack of clinical suspicion of AE led to their misdiagnosis. We present these two patients to further characterize the bullous variant of AE, and we review the previously reported clinical and histopathological findings.

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