Acrodermatitis Enteropathica-Like Eruption Associated with Parenteral Nutrition

Katoh, Taizo; Igarashi, Minoru; Ohhashi, Eisuke; Ohi, Ryoji; Hebiguchi, Tatuzo; Seiji, Makoto

doi:10.1159/000251170

Cited by 7 publications

(2 citation statements)

References 6 publications

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“…They include megaloblastic anemia due to folate deficiency [3], sev eral cutaneous manifestations allegedly due to essential fatty acids deficiency [11,17], anemia, leukopenia and neutropenia attributed to copper deficiency [8,16] and an AE-like syndrome linked to zinc deficiency [18], despite that the need for supplementation of trace elements during TPA has been pro posed [36].…”

Section: Discussionmentioning

confidence: 99%

Acquired Zinc Deficiency Syndrome during Total Parenteral Alimentation

et al. 1981

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An acute zinc deficiency state developed in 6 patients on total parenteral alimentation, which allegedly included zinc 37 μmol/l. The actual concentration of this trace element when measured by us, was 3 μmol/l. The clinical picture consisted of an acrodermatitis enteropathica-like syndrome, with subsequent development of distinctive nail lesions, which consisted of white transverse bands in all finger- and toenails. Histopathological examination of several of these cutaneous lesions revealed distinctive changes, which we consider rather specific of zinc deficiency states. They consisted in parakeratosis, cleavage and detachment of the superficial layers of the epidermis, mainly intracellular and also extracellular edema of the epidermal cells, development of microvesicles at different epidermal levels, and severe vacuolar alteration of the dermoepidermal junction. These changes also affected the outer root sheath of the hair follicles.

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Section: Discussionmentioning

confidence: 99%

Acquired Zinc Deficiency Syndrome during Total Parenteral Alimentation

et al. 1981

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“…1 However, the importance of zinc and the relationship of this metal to diseases of the skin has only recently been recognized.2 5 The intro¬ duction of total parenteral nutrition (TPN) in the treatment of serious and debilitating disorders of the gastroin¬ testinal (GI) tract, or in the treatment of otherwise severely malnourished individuals, has emphasized the im¬ portance of trace elements in human physiology.8 Total parenteral nutri-tion allows the investigator to define precisely the role of dietary factors. It further allows for quantitative control of metabolic studies, particularly in relation to specific trace elements.…”

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confidence: 99%