Acrodermatitis chronica atrophicans: a case report and review of the literature

Leslie, Tabi A.; Levell, N. J.; Cutler, Sally J.; Cann, Kathryn; Smith, Martin H.; Wright, David J.; Gilkes, J. J. H.; Robinson, T. W. E.

doi:10.1111/j.1365-2133.1994.tb04984.x

Cited by 23 publications

(18 citation statements)

References 37 publications

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“…Der Erreger ist eine 1982 entdeckte und als Borrelia burgdorferi bezeichnete Spirochäte, welche durch den Stich der als Schafzecke bekannten Ixodes ricinus übertragen wird. Nach den Frühmanifestationen sind erythrozyanotische Hautläsionen bevorzugt an den Streckseiten der Extremitäten, die nach entzündlich-ödematösem Beginn in das Stadium der Atrophie über-gehen, charakteristisch [2,8,9]. Die Erkrankung kommt in weiten Teilen Europas, selten in Nord-und Südamerika vor.…”

Section: Juxta-artikul äRe Fibroide Knoten (Jfk)unclassified

Juxta-artikuläre fibroide Knoten und Acrodermatitis chronica atrophicans bei Lyme-Borreliose im Spätstadium

Kluge¹,

Krahl²,

Kramer³

et al. 2000

Der Hautarzt

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Section: Juxta-artikul äRe Fibroide Knoten (Jfk)unclassified

Juxta-artikuläre fibroide Knoten und Acrodermatitis chronica atrophicans bei Lyme-Borreliose im Spätstadium

Kluge¹,

Krahl²,

Kramer³

et al. 2000

Der Hautarzt

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“…In some patients with chronic disease, immune or other less wellcharacterized mechanisms are the cause of the symptoms. For example, in PCR-positive and culture-negative ACA lesions, live bacteria are scanty or not present, but nevertheless the symptoms prevail (7). In other long-term disease manifestations, immune mechanisms are common even without detectable spirochetes.…”

Section: Lysine-dependent Multipoint Binding Of the Borrelia Burgdorfmentioning

confidence: 99%

Lysine-Dependent Multipoint Binding of theBorrelia burgdorferiVirulence Factor Outer Surface Protein E to the C Terminus of Factor H

Alitalo

Meri

Chen

et al. 2004

The Journal of Immunology

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Serum resistance, an important virulence determinant of Borrelia burgdorferi sensu lato strains belonging to the Borrelia afzelii and B. burgdorferi sensu stricto genotypes, is related to binding of the complement inhibitor factor H to the spirochete surface protein outer surface protein E (OspE) and its homologues. In this study, we show that the C-terminal short consensus repeats 18–20 of both human and mouse factor H bind to OspE. Analogously, factor H-related protein 1, a distinct plasma protein with three short consensus repeat domains homologous to those in factor H, bound to OspE. Deleting 15-aa residues (region V) from the C terminus of the OspE paralog P21 (a 20.7-kDa OspE-paralogous surface lipoprotein in the B. burgdorferi sensu stricto 297 strain) abolished factor H binding. However, C-terminal peptides from OspE, P21, or OspEF-related protein P alone and the C-terminal deletion mutants of P21 inhibited factor H binding to OspE only partially when compared with full-length P21 or its N-terminal mutant. Alanine substitution of amino acids in peptides from the key binding regions of the OspE family indicated that several lysine residues are required for factor H binding. Thus, the borrelial OspE family proteins bind the C inhibitor factor H via multiple sites in a lysine-dependent manner. The C-terminal site V (Ala151-Lys166) is necessary, but not sufficient, for factor H binding in both rodents and humans. Identification of the necessary binding sites forms a basis for the development of vaccines that block the factor H-OspE interaction and thereby promote the killing of Borreliae.

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“…Annular, bull's-eye shaped erythema migrans at the site of the tick bite the later stages. Once established, the atrophy usually persists despite treatment (28). Peripheral neuropathy of the involved limb occurs in more than half of patients with a long-lasting ACA lesion (29).…”

Section: Cutaneous Manifestations Of Lyme Diseasementioning

confidence: 99%

Ticks, Borrelia Burgdorferi and Lyme Disease

Bağcı¹,

Ruzicka²

2016

tdd

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Lyme disease, which is caused by spirochete Borrelia burgdorferi sensu lato, is a ticktransmitted, multisystem infectious disease. It occurs in stages, with different clinical manifestations at each stage. Erythema migrans is the most frequent manifestation which occurs at the site of the tick bite. Borrelial lymphocytoma and acrodermatitis chronica atrophicans are late-stage cutaneous manifestations. Extracutaneous signs of infection most often involve the musculoskeletal, cardiovascular, and nervous systems. Serologic assays remain the mainstay of diagnosis. All stages of the disease are curable with appropriate antibiotic therapy. Keywords: Lyme disease, Borrelia burgdorferi, erythema migrans, acrodermatitis chronica atrophicans, ticks, Ixodes Işın Sinem Bağcı, Thomas Ruzicka* Ticks, Borrelia Burgdorferi and Lyme DiseaseKeneler, Borrelia Burgdorferi ve Lyme Hastalığı Öz AbstractLyme hastalığı Borrelia burgdorferi sensu lato grubu spiroketlerin sebep olduğu multisistemik bir enfeksiyon hastalığıdır. Her hastalık evresi değişik klinik bulgularla kendini gösterir. En sık klinik bulgusu kene ısırık yerinde gelişen eritema migranstır. Borrelial lenfositoma ve akrodermatitis kronika atrofikans geç dönemde gelişen deri bulgularıdır. Deri bulguları dışında kas-iskelet, kardiyovasküler ve sinir sistemi tutulumu da görülebilir. Tanı serolojik testler ile konulur. Hastalığın her evresi uygun antibiyotiklerle tedavi edilebilir.

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Acrodermatitis chronica atrophicans: a case report and review of the literature

Cited by 23 publications

References 37 publications

Juxta-artikuläre fibroide Knoten und Acrodermatitis chronica atrophicans bei Lyme-Borreliose im Spätstadium

Juxta-artikuläre fibroide Knoten und Acrodermatitis chronica atrophicans bei Lyme-Borreliose im Spätstadium

Lysine-Dependent Multipoint Binding of theBorrelia burgdorferiVirulence Factor Outer Surface Protein E to the C Terminus of Factor H

Ticks, Borrelia Burgdorferi and Lyme Disease

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