Acridones from<i>Vepris fitoravina</i>and<i>Vepris macrophylla</i>

Koffi, Yao; Gleye, J.; Moulis, Claire; Stanislas, E

doi:10.1055/s-2006-962815

Cited by 8 publications

(2 citation statements)

References 3 publications

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“…ex A. Juss. (Rutaceae) comprises approximately 100 species according to different botanical databases, namely TROPICOS, the International Plant Names Index, and the Plant List [5,6]. It consists of shrubs and trees, widespread mainly in tropical Africa, Zanzibar, Madagascar, Comoros, and the Mascarene Islands (Indian Ocean Islands) [7].…”

Section: Introductionmentioning

confidence: 99%

Evaluating Phytochemical Profiles, Cytotoxicity, Antiviral Activity, Antioxidant Potential, and Enzyme Inhibition of Vepris boiviniana Extracts

Bakar,

Nilofar,

Mohamed

et al. 2023

Molecules

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In the present study, we performed comprehensive LC-MS chemical profiling and biological tests of Vepris boiviniana leaves and stem bark extracts of different polarities. In total, 60 bioactive compounds were tentatively identified in all extracts. The 80% ethanolic stem bark extract exhibited the highest activity in the ABTS assay, equal to 551.82 mg TE/g. The infusion extract of stem bark consistently demonstrated elevated antioxidant activity in all assays, with values ranging from 137.39 mg TE/g to 218.46 mg TE/g. Regarding the enzyme inhibitory assay, aqueous extracts from both bark and leaves exhibited substantial inhibition of AChE, with EC50 values of 2.41 mg GALAE/g and 2.25 mg GALAE/g, respectively. The 80% ethanolic leaf extract exhibited the lowest cytotoxicity in VERO cells (CC50: 613.27 µg/mL) and demonstrated selective cytotoxicity against cancer cells, particularly against H1HeLa cells, indicating potential therapeutic specificity. The 80% ethanolic bark extract exhibited elevated toxicity in VERO cells but had reduced anticancer selectivity. The n-hexane extracts, notably the leaves’ n-hexane extract, displayed the highest toxicity towards non-cancerous cells with selectivity towards H1HeLa and RKO cells. In viral load assessment, all extracts reduced HHV-1 load by 0.14–0.54 log and HRV-14 viral load by 0.13–0.72 log, indicating limited antiviral activity. In conclusion, our research underscores the diverse bioactive properties of Vepris boiviniana extracts, exhibiting potent antioxidant, enzyme inhibitory, and cytotoxicity potential against cancer cells.

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Section: Introductionmentioning

confidence: 99%

Evaluating Phytochemical Profiles, Cytotoxicity, Antiviral Activity, Antioxidant Potential, and Enzyme Inhibition of Vepris boiviniana Extracts

Bakar,

Nilofar,

Mohamed

et al. 2023

Molecules

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“…The African Vepris species have proved to be a good source of furoquinoline and acridone alkaloids that typify the genus as a whole. V. bilocularis has been found to have both furoquinoline as well as acridone alkaloids [1,2], while furoquinoline alkaloids alone have been found in V. ampody [3], V. heterophylla [4], V. punctata [5] and V. stolzii [6], and acridone alkaloids alone in V. fitoravina and V. macrophylla [7]. The alkaloids are reported to possess broad spectrum antimicrobial [8], antiradical [9], antioxidant [10], antiplasmodial [11], anticancer [12] and antimutagenic [13] activities.…”

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A Novel Flavonoid and Furoquinoline Alkaloids from Vepris glomerata and their Antioxidant Activity

Kiplimo

Islam

Koorbanally

2011

Natural Product Communications

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The dichloromethane extract of the aerial part of the plant Vepris glomerata (Rutaceae) yielded a new flavonoid, which was accorded the trivial name veprisinol (1), together with four known furoquinoline alkaloids: haplopine-3,3'-dimethylallyl ether (2), anhydroevoxine (3), evoxine (4) and skimmianine (5). The structures of the compounds were established by 1D and 2D NMR spectroscopy, as well as HREIMS. Compounds 1 and 2 have strong antioxidant potential, similar to and in some instances better than ascorbic acid and can be used as beneficial additives to antioxidant supplements.

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Chemical Composition and in vitro Biological Activities of the Essential Oil of Vepris macrophylla (Baker) I.Verd. Endemic to Madagascar

Maggi

Randriana

Rasoanaivo

et al. 2013

Chemistry & Biodiversity

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Vepris macrophylla is an evergreen tree occurring in sub-humid forest of Madagascar and traditionally used in the Island to treat several complaints as well as to prepare aromatic teas and alcoholic drinks. In the present work, the essential oil distilled from the leaves was analyzed for the first time by gas chromatography (GC-FID) and gas chromatography/mass spectrometry (GC/MS). The major compounds were citral (56.3%), i.e., mixture of neral (23.1%) and geranial (33.2%), citronellol (14.5%), and myrcene (8.3%). The essential oil exhibited antimicrobial activity against S. aureus, P. aeruginosa, and C. albicans as determined by vapor-diffusion assay, supporting the traditional use of the plant for preparing steam bath for the treatment of infectious diseases. The essential oil was evaluated for cytotoxic activity on human tumor cell lines by MTT (=3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay, showing inhibitory effects comparable to those of cisplatin, notably on MDA-MB 231 (human breast adenocarcinoma) and HCT116 (human colon carcinoma) cell lines. Finally, the essential oil was also subjected to screening for its antioxidant activity and the free radical scavenging capacity.

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Acridones fromVepris fitoravinaandVepris macrophylla

Cited by 8 publications

References 3 publications

Evaluating Phytochemical Profiles, Cytotoxicity, Antiviral Activity, Antioxidant Potential, and Enzyme Inhibition of Vepris boiviniana Extracts

Evaluating Phytochemical Profiles, Cytotoxicity, Antiviral Activity, Antioxidant Potential, and Enzyme Inhibition of Vepris boiviniana Extracts

A Novel Flavonoid and Furoquinoline Alkaloids from Vepris glomerata and their Antioxidant Activity

Chemical Composition and in vitro Biological Activities of the Essential Oil of Vepris macrophylla (Baker) I.Verd. Endemic to Madagascar

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