Acretnonium kiliense in oesophagus stenosis

Simon, Graham; Rákóczy, G; Galgóczy, J.; Verebély, Tibor; Bókay, János

doi:10.1111/j.1439-0507.1991.tb00655.x

Cited by 17 publications

(3 citation statements)

References 10 publications

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“…There are no accepted guidelines for the treatment of Acremonium infections. Our patient responded well to a 2‐month course of ketoconazole, and the previously described patient required 100 mg/day of itraconazole for 3 months (11). The literature supports the use of ketoconazole and fluconazole in less serious cases or while awaiting susceptibility data.…”

Section: Discussionsupporting

confidence: 60%

See 1 more Smart Citation

Acremonium Infection of the Esophagus

Mascarenhas,

McGowan,

Ruchelli

et al. 1997

J. pediatr. gastroenterol. nutr.

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Section: Discussionsupporting

confidence: 60%

“…There is only one previously reported case of A. kiliense infection in an 11‐year‐old boy also associated with peptic esophageal disease (11). This patient had Acremonium esophagitis, gastroesophageal reflux resulting in an esophageal stricture, and was successfully treated with itraconzole and antireflux surgery.…”

Section: Discussionmentioning

confidence: 99%

Acremonium Infection of the Esophagus

Mascarenhas,

McGowan,

Ruchelli

et al. 1997

J. pediatr. gastroenterol. nutr.

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“…Five of these cases were reported from the United States (4,8), four each were reported from Brazil (15,16,20,29) and India (6,11,37), two each were reported from Argentina (2, 26) and France (17,19), and one was reported from Hungary (35). Only three of these cases occurred in immunocompromised patients, and the fungus was isolated from heart and brain tissue (15), blood (17), and lung tissue (29).…”

Section: Case Reportmentioning

confidence: 99%

Acremonium kiliense: Reappraisal of Its Clinical Significance

et al. 2011

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A case of Acremonium kiliense peritonitis is described. Diagnosis was established by repeated isolation of the fungus from peritoneal dialysate and by its identification on the basis of morphological characteristics and sequencing of internal transcribed spacer (ITS) regions of ribosomal DNA (rDNA). This report and available literature suggest that A. kiliense may have a greater clinical significance than hitherto recognized. CASE REPORTA 75-year-old Jordanian man with a long history of diabetes mellitus and hypertension developed end-stage kidney disease requiring continuous ambulatory peritoneal dialysis (CAPD). His course of CAPD was largely uneventful except for a single episode of bacterial peritonitis, for which he was hospitalized and treated with parenteral antibiotics, with an excellent response. In January 2010, he became febrile, with clinical evidence of peritonitis, and was admitted to the hospital. The peritoneal fluid was turbid, with a white blood cell (WBC) count of 2.1 ϫ 10 9 /liter. On initial microscopic examination, the presence of fungal elements in the peritoneal dialysate was missed. The peritoneal fluid sample was inoculated into aerobic Bactec blood culture bottles, which yielded a growth after 59 h of incubation. The Gram-stained smear from blood culture bottles showed branched hyphal elements. On Sabouraud dextrose agar (SDA; Oxoid Ltd., Basingstoke, England), the specimen yielded slimy colonies with a pinkish appearance ( Fig. 1). Microscopic examination of the primary culture (isolate Kw441-2010) showed hyaline hyphae, with scanty sporulation. A provisional identification of Acremonium/Fusarium species was made, and the growth was subcultured on Sabouraud dextrose agar and oatmeal agar (OMA; oatmeal [30 g], agar [20 g], distilled water [1 liter]) for further identification and antifungal susceptibility testing. Subsequent cultures of the peritoneal fluid yielded the same fungus on three occasions. A serum sample was obtained for the detection of galactomannan (Platelia Aspergillus enzyme immunoassay [EIA] kit; BioRad, Marnes-la-Coquette, France) and (1-3)-␤-D-glucan (Fungitell; Associates of Cape Cod); the latter test was positive (253 pg/ml). An Etest performed on RPMI 1640 medium supplemented with 2% glucose revealed that the isolate was resistant to amphotericin B and caspofungin but susceptible to voriconazole and posaconazole, with MIC values of Ͼ32 g/ml, Ͼ32 g/ml, 0.064 g/ml, and 0.75 g/ml, respectively. The patient was started on voriconazole, with a loading dose of 400 mg, followed by a maintenance dose of 200 mg, given every 12 h via the oral route. Although the patient showed clinical improvement after 2 weeks of voriconazole therapy, the peritoneal dialysate remained turbid (WBC counts, 2.0 ϫ 10 9 / liter). Abdominal ultrasound examination did not reveal any evidence of intraperitoneal adhesions or organ invasion. Since the response to treatment was not adequate, the Tenckhoff catheter was removed and the patient was temporarily switched to hemodialysis. After 1 week of a...

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Acremonium pyomyositis in a pediatric patient with acute leukemia

Chang

Huang

Hsueh

et al. 2004

Pediatric Blood & Cancer

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Invasive Acremonium infection in humans is rare. We report a patient with leukemia who developed pyomyositis due to Acremonium species. Painful cutaneous nodules and severe myalgia were the first clinical manifestations during the neutropenic stage after chemotherapy. Magnetic resonance image (MRI) revealed multiple nodular lesions scattered along the intramuscular regions of the lower legs. Culture of an aspiration grew Acremonium species. Surgical drainage was performed. Although all antifungal agents tested showed no in vitro inhibitory activity, we successfully treated this patient with amphotericin B, granulocyte colony-stimulating factor (G-CSF), and surgical drainage.

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Acretnonium kiliense in oesophagus stenosis

Cited by 17 publications

References 10 publications

Acremonium Infection of the Esophagus

Acremonium Infection of the Esophagus

Acremonium kiliense: Reappraisal of Its Clinical Significance

Acremonium pyomyositis in a pediatric patient with acute leukemia

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