Acremonium sclerotigenum-Acremonium egyptiacum: a multi-resistant fungal pathogen complicating the course of aplastic anaemia

Guitard, Juliette; Degulys, A.; Buot, G.; Aline-Fardin, Aude; Dannaoui, Éric; B, Rio; Marie, Jean Pierre; Lapusan, Simona; Hennequin, Christophe

doi:10.1111/1469-0691.12319

Cited by 12 publications

(11 citation statements)

References 13 publications

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“…to antifungals, but they are characteristically resistant to anti-Candida agents, such as fluconazole and flucytosine 31 . Although breakpoint data for those organisms are lacking, MICs of amphotericin B are commonly elevated, which suggests the poor activity of this drug.…”

Section: Discussionmentioning

confidence: 99%

Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital

Junior

Silva

Arantes

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: Invasive fungal infections (IFIs) are an important complication in immunocompromised individuals, particularly neutropenic patients with hematological malignancies. In this study, we aimed to verify the epidemiology and diagnosis of IFIs in patients with hematologic problems at a tertiary hospital in Goiânia-GO, Brazil. Methods: Data from 117 patients, involving 19 cases of IFIs, were collected. The collected data included diagnosis methods, demographics, clinical characteristics, and in vitro susceptibility to different antifungal agents. Among the 19 cases, 12 were classified as proven IFI and 7 as probable invasive aspergillosis with detection of galactomannan in blood and presence of lung infiltrates in radiographic images. Logistic regression analysis showed that the proven and probable IFIs were associated with increased risk of death. Statistical analysis demonstrated that age, sex, and underlying disease were not independently associated with risk of death in IFI patients. Results: Most bloodstream isolates of Candida spp. exhibited low minimum inhibitory concentrations (MICs) to all antifungal agents tested. Voriconazole and amphotericin had the lowest MICs for Aspergillus spp. and Fusarium spp., but Fusarium spp. showed the least susceptibility to all antifungals tested. Amphotericin B, fluconazole, and itraconazole were found to be inactive in vitro against Acremonium kiliense; but this fungus was sensitive to voriconazole. Conclusions: Considering the high number of IFI cases, with crude mortality rate of 6%, we could conclude that IFIs remain a common infection in patients with hematological malignancies and underdiagnosed ante mortem. Thus, IFIs should be monitored closely.

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Section: Discussionmentioning

confidence: 99%

Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital

Junior

Silva

Arantes

et al. 2017

Rev. Soc. Bras. Med. Trop.

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“…This species has been reported in several cases of disseminated infection, but sequencing analyses showed that they were, in fact, caused by A egyptiacum. 5,12,15 However, A strictum, belonging to the genogroup IV, has indeed been reported as the causal agent of an osteomyelitis case successfully treated with voriconazole (VRC). 16 In addition, other cases of disseminated infection, 17 brain abscess, 18 bone marrow transplant, 19 pulmonary infections, [20][21][22] meningitis, 23 soft tissue infection in an immunocompetent patient, 18 fungaemia, 24-28 endocarditis 29 (with the fungus being later reidentified as A egyptiacum 5 ), peritonitis, 30,31 cutaneous or subcutaneous infections 11,[32][33][34] and onychomycosis 5 have also been linked to this species, although these cases not have not been confirmed molecularly.…”

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confidence: 99%

SarocladiumandAcremoniuminfections: New faces of an old opportunistic fungus

Pérez-Cantero

Guarro

2020

Mycoses

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The genera Sarocladium and Acremonium (order Hypocreales) are a very diverse group of morphologically and genetically related fungi that are generally found in the environment. Numerous species of these genera are soil saprobes and opportunistic pathogens of plants, other fungi, animals or humans. 1 They are distributed worldwide, and Acremonium isolates have even been found in rocks on continental Antarctica. 2 In addition, these fungi are very relevant in the clinical field, as they have been proven to be involved in a wide range of human conditions and manifestations. As will be discussed later, diagnosis and management of these infections are quite challenging, mostly due to the difficulties in the correct identification and to the poor antifungal response they generally show. As a matter of fact, Acremonium and Sarocladium species cannot be distinguished by histopathological examination from some other opportunistic fungi, such as Fusarium and its relatives; therefore, DNA sequence analysis is required. This review, based on an exhaustive literature search of the PubMed database, compiles and discusses the current knowledge of Sarocladium and Acremonium infections in terms of taxonomy, clinical presentations and prognoses, diagnosis, treatment, outcomes, antifungal susceptibility and their impact in animals.

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“…The foodborne pathogens play an important role to infect human and animals (24). On the other hand, it can result in localized infection through traumatic contamination such as mycetoma, onychomycosis, keratitis (25) and in rare cases disseminated infection in immunosuppressed host (26)(27)(28). The most organs affected were spleen, liver and kidney.…”

Section: Discussionmentioning

confidence: 99%

Experimental infection in mice with Acremonium spp. mold and Rhodotorula spp. yeast isolated from cow's milk

Yassein¹,

Zghair²

2020

IJVS

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This study was performed in isolation of some pathogenic fungi from milk of apparently healthy cows. Eighty milk samples were collected from four quarters of twenty cows in the Abu Ghraib. Each sample was cultured on Sabouraud dextrose Agar at 28±2 ºC for 4-7 days. The most predominant mold and yeast were Acremonium spp. and Rhodotorula spp. that had used in the experimental infection. The number of experimental mice used in this study was 30 which divided into three equal groups. The 1 st group was infected with Acremonium spp. by injection of 0.2 ml of 2*10 7 conidia/ml intraperitoneally. The 2 nd group was inoculated with same dose and route with Rhodotorula spp., while the 3 rd group served as control group. All mice were sacrificed after 2 weeks of injection, Serum was obtained for biochemical analysis of hepatic and renal enzymes. Some of internal organs of infected groups were taken for histopathological study. The result recorded that the total percentage of fungal infection was 53 (66.3%) of these Acremonium spp. 9 (24.3%) and Rhodotorula spp. 7 (43.8%). Histopathological sections of the 1 st group showed severe lesions in kidney than 2 nd group although both groups showed lesions in most internal organs. Blood biochemical results showed the yeast has highest significant differences on ALT levels, while the mold has highest effect on serum creatinine, with insignificant difference on urea. In conclusion it could be said that in spite of Acremonium spp. and Rhodotorula spp. are considered as contaminant fungi, but they can cause disseminated mycosis in mice.

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Acremonium sclerotigenum-Acremonium egyptiacum: a multi-resistant fungal pathogen complicating the course of aplastic anaemia

Cited by 12 publications

References 13 publications

Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital

Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital

SarocladiumandAcremoniuminfections: New faces of an old opportunistic fungus

Experimental infection in mice with Acremonium spp. mold and Rhodotorula spp. yeast isolated from cow's milk

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