Acremonium pneumonia in an AIDS patient

Niknam, Negin; Mankame, Siddhi; Ha, Lawrence; Gautam-Goyal, Pranisha

doi:10.1016/j.idcr.2017.04.009

Cited by 2 publications

(6 citation statements)

References 7 publications

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“…A total of 18 cases of respiratory infections by species of these genera have been reported [20][21][22][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87] from the United States, Brazil, Spain, Turkey, South Africa, Nigeria, India and Iran.…”

Section: Respiratory Infectionsmentioning

confidence: 99%

“…Disease manifestation included the following: pleuritis, 80 pneumonitis, 74 77 colon adenocarcinoma, 80 midline granuloma 79 and diabetes. 85,86 Diagnosis was based on the presence of the fungus on sputum, 73 BAL cultures, 80,85 abscesses cultures or abscesses biopsies, 20,21,75 blood culture 80 or chest CT. 20,21,73,85,86 Regarding treatments, the successful therapeutic approaches included AMB in three cases, VRC in two cases 73,76 and posaconazole (PSC) in one. 21 By contrast, AMB combined with itraconazole (ITC) failed, resulting in the death of the patient.…”

Section: Respiratory Infectionsmentioning

confidence: 99%

“…Disease manifestation included the following: pleuritis, 80 pneumonitis, 74 pneumonia, 76,77 rhinosinusitis 78 and pansinusitis, 79 the most common symptoms being fever, chest pain, respiratory distress, tachypnea, lung crackles, dyspnoea, cough, night sweat, chills, purulent sputum, numerous areas of consolidation, oedema and abscesses. Underlying diseases that favoured the infection were leukaemia, 21 renal transplant, 75 AIDS, 73 chronic granulomatous disease, 77 colon adenocarcinoma, 80 midline granuloma 79 and diabetes 85,86 . Diagnosis was based on the presence of the fungus on sputum, 73 BAL cultures, 80,85 abscesses cultures or abscesses biopsies, 20,21,75 blood culture 80 or chest CT 20,21,73,85,86 …”

Section: Clinical Casesmentioning

confidence: 99%

“…Underlying diseases that favoured the infection were leukaemia, 21 renal transplant, 75 AIDS, 73 chronic granulomatous disease, 77 colon adenocarcinoma, 80 midline granuloma 79 and diabetes 85,86 . Diagnosis was based on the presence of the fungus on sputum, 73 BAL cultures, 80,85 abscesses cultures or abscesses biopsies, 20,21,75 blood culture 80 or chest CT 20,21,73,85,86 …”

Section: Clinical Casesmentioning

confidence: 99%

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SarocladiumandAcremoniuminfections: New faces of an old opportunistic fungus

Pérez-Cantero

Guarro

2020

Mycoses

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The genera Sarocladium and Acremonium (order Hypocreales) are a very diverse group of morphologically and genetically related fungi that are generally found in the environment. Numerous species of these genera are soil saprobes and opportunistic pathogens of plants, other fungi, animals or humans. 1 They are distributed worldwide, and Acremonium isolates have even been found in rocks on continental Antarctica. 2 In addition, these fungi are very relevant in the clinical field, as they have been proven to be involved in a wide range of human conditions and manifestations. As will be discussed later, diagnosis and management of these infections are quite challenging, mostly due to the difficulties in the correct identification and to the poor antifungal response they generally show. As a matter of fact, Acremonium and Sarocladium species cannot be distinguished by histopathological examination from some other opportunistic fungi, such as Fusarium and its relatives; therefore, DNA sequence analysis is required. This review, based on an exhaustive literature search of the PubMed database, compiles and discusses the current knowledge of Sarocladium and Acremonium infections in terms of taxonomy, clinical presentations and prognoses, diagnosis, treatment, outcomes, antifungal susceptibility and their impact in animals.

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Section: Respiratory Infectionsmentioning

confidence: 99%

Section: Respiratory Infectionsmentioning

confidence: 99%

Section: Clinical Casesmentioning

confidence: 99%

Section: Clinical Casesmentioning

confidence: 99%

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SarocladiumandAcremoniuminfections: New faces of an old opportunistic fungus

Pérez-Cantero

Guarro

2020

Mycoses

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“…The foodborne pathogens play an important role to infect human and animals (24). On the other hand, it can result in localized infection through traumatic contamination such as mycetoma, onychomycosis, keratitis (25) and in rare cases disseminated infection in immunosuppressed host (26)(27)(28). The most organs affected were spleen, liver and kidney.…”

Section: Discussionmentioning

confidence: 99%

Experimental infection in mice with Acremonium spp. mold and Rhodotorula spp. yeast isolated from cow's milk

Yassein¹,

Zghair²

2020

IJVS

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This study was performed in isolation of some pathogenic fungi from milk of apparently healthy cows. Eighty milk samples were collected from four quarters of twenty cows in the Abu Ghraib. Each sample was cultured on Sabouraud dextrose Agar at 28±2 ºC for 4-7 days. The most predominant mold and yeast were Acremonium spp. and Rhodotorula spp. that had used in the experimental infection. The number of experimental mice used in this study was 30 which divided into three equal groups. The 1 st group was infected with Acremonium spp. by injection of 0.2 ml of 2*10 7 conidia/ml intraperitoneally. The 2 nd group was inoculated with same dose and route with Rhodotorula spp., while the 3 rd group served as control group. All mice were sacrificed after 2 weeks of injection, Serum was obtained for biochemical analysis of hepatic and renal enzymes. Some of internal organs of infected groups were taken for histopathological study. The result recorded that the total percentage of fungal infection was 53 (66.3%) of these Acremonium spp. 9 (24.3%) and Rhodotorula spp. 7 (43.8%). Histopathological sections of the 1 st group showed severe lesions in kidney than 2 nd group although both groups showed lesions in most internal organs. Blood biochemical results showed the yeast has highest significant differences on ALT levels, while the mold has highest effect on serum creatinine, with insignificant difference on urea. In conclusion it could be said that in spite of Acremonium spp. and Rhodotorula spp. are considered as contaminant fungi, but they can cause disseminated mycosis in mice.

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Acremonium pneumonia in an AIDS patient

Cited by 2 publications

References 7 publications

SarocladiumandAcremoniuminfections: New faces of an old opportunistic fungus

SarocladiumandAcremoniuminfections: New faces of an old opportunistic fungus

Experimental infection in mice with Acremonium spp. mold and Rhodotorula spp. yeast isolated from cow's milk

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